Expression of Stress-Induced Genes in Bronchoalveolar Lavage Cells and Lung Fibroblasts from Healthy and COPD Subjects

• Published in: International journal of molecular sciences Vol. 25; no. 12; p. 6600
• Main Authors: Garcia-Ryde, Martin, van der Burg, Nicole M. D., Berlin, Frida, Westergren-Thorsson, Gunilla, Bjermer, Leif, Ankerst, Jaro, Larsson-Callerfelt, Anna-Karin, Andersson, Cecilia K., Tufvesson, Ellen
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 15.06.2024; MDPI
• Subjects: Aged; Apoptosis; Apoptosis - genetics; Bronchoalveolar Lavage Fluid - cytology; Case-Control Studies; Cell growth; Cell Proliferation; Cells, Cultured; Chronic obstructive pulmonary disease; Cigarettes; Clinical Medicine; Comparative analysis; Endoplasmic reticulum; Endoplasmic Reticulum Stress - genetics; Female; Fibroblasts; Fibroblasts - metabolism; Gene expression; Gene Expression Regulation; Genes; Humans; Investigations; Kinases; Klinisk medicin; Lavage; Localization; Lung - metabolism; Lung - pathology; Lung diseases, Obstructive; Lungmedicin och allergi; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Middle Aged; Oxidative stress; Proteins; Pulmonary Disease, Chronic Obstructive - etiology; Pulmonary Disease, Chronic Obstructive - genetics; Pulmonary Disease, Chronic Obstructive - metabolism; Pulmonary Disease, Chronic Obstructive - pathology; Respiratory Medicine and Allergy; Scientific equipment and supplies industry; Smoking; Transcription factors; United States; Sweden; lung fibroblast; cigarette smoke extract; protein; ER stress; bronchoalveolar lavage; gene expression; COPD

Chronic obstructive pulmonary disease (COPD) is commonly caused from smoking cigarettes that induce biological stress responses. Previously we found disorganized endoplasmic reticulum (ER) in fibroblasts from COPD with different responses to chemical stressors compared to healthy subjects. Here, we...