Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease - Trinchese, Fabrizio; Fa’, Mauro; Liu, Shumin; Zhang, Hong; Hidalgo, Ariel; Schmidt, Stephen D.; Yamaguchi, Hisako; Yoshii, Narihiko; Mathews, Paul M.; Nixon, Ralph A.; Arancio, Ottavio (The Journal of clinical investigation, 2008)
Keywords: Alzheimer Disease - drug therapy; Alzheimer Disease - metabolism; Alzheimer Disease - physiopathology; Alzheimer's disease; Animals; Biomedical research; Calpain; Calpain - antagonists & inhibitors; Cell culture; Cells, Cultured; Control; Cyclin-dependent kinases; Disease Models, Animal; Enzymes; Glycoproteins - pharmacology; Hippocampus - cytology; Hippocampus - metabolism; Homozygote; Immunohistochemistry; Kinases; Leucine - analogs & derivatives; Leucine - pharmacology; Localization; Memory; Memory - drug effects; Mice; Mice, Transgenic; Models, Neurological; Neural transmission; Peptides; Phosphorylation; Physiological aspects; Proteins; Synaptic Transmission - drug effects; United States