Alterations in GABA-related transcriptome in the dorsolateral prefrontal cortex of subjects with schizophrenia

• Published in: Molecular psychiatry Vol. 13; no. 2; pp. 147 - 161
• Main Authors: Hashimoto, T, Arion, D, Unger, T, Maldonado-Avilés, J G, Morris, H M, Volk, D W, Mirnics, K, Lewis, D A
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2008; Nature Publishing Group
• Subjects: Acids; Adult; Adult and adolescent clinical studies; Aged; Animals; Antipsychotic Agents - pharmacology; Antipsychotics; Behavioral Sciences; Benzodiazepines - pharmacology; Biological and medical sciences; Biological Psychology; Case-Control Studies; Chloroquinolinols - pharmacology; Cholecystokinin; DNA microarrays; Female; GABA; GABA Plasma Membrane Transport Proteins - genetics; GABA Plasma Membrane Transport Proteins - metabolism; Gene Expression Regulation - drug effects; Gene Expression Regulation - physiology; Genetic aspects; Glutamate decarboxylase; Glutamate Decarboxylase - genetics; Glutamate Decarboxylase - metabolism; Glutamic acid; Health aspects; Humans; Hybridization; Hypotheses; Macaca fascicularis; Male; Medical sciences; Medicine; Medicine & Public Health; Memory; Mental disorders; Middle Aged; Monkeys & apes; Neurons; Neuropeptide Y; Neuropeptides; Neuropeptides - genetics; Neuropeptides - metabolism; Neurosciences; Neurotransmission; Neurotransmitters; Olanzapine; Oligonucleotide Array Sequence Analysis - methods; original-article; Pharmacotherapy; Physiological aspects; Prefrontal cortex; Prefrontal Cortex - metabolism; Properties; Protein Subunits - genetics; Protein Subunits - metabolism; Proteins; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Receptors, GABA-A - genetics; Receptors, GABA-A - metabolism; Schizophrenia; Schizophrenia - pathology; Short term memory; Somatostatin; Transcriptomes; γ-Aminobutyric acid A receptors; United States; United States > US; Pittsburgh Pennsylvania; microarray; receptor; quantitative PCR; GABA; neuropeptides; GAD; hybridization; Human; Molecular hybridization; Enzyme; Schizophrenia; Lyases; Glutamate decarboxylase; Neuropeptide; Psychosis; Dorsolateral prefrontal cortex; Polymerase chain reaction; Carbon-carbon lyases; Carboxy-lyases; Neurotransmitter; Genetics; Molecular biology; GABAA receptor; Gabaergic receptor A; in situ hybridization

In subjects with schizophrenia, impairments in working memory are associated with dysfunction of the dorsolateral prefrontal cortex (DLPFC). This dysfunction appears to be due, at least in part, to abnormalities in γ -aminobutyric acid (GABA)-mediated inhibitory circuitry. To test the hypothesis tha...