910-P: Novel Mechanism of Action Associated with SGLT2 Inhibition, Peripheral Energy Utilization, and CV Benefits in Subjects with Type 2 Diabetes Mellitus and HFrEF

• Published in: Diabetes (New York, N.Y.) Vol. 73; no. Supplement_1; p. 1
• Main Authors: QIN, YUEJUAN, SANCHEZ, NOAH D., ACOSTA, FRANCISCA M., MOODY, ALEXANDER, NEPPALA, SIVARAM, TRIPLITT, CURTIS L., CLARKE, GEOFFREY D., CERSOSIMO, EUGENIO, DEFRONZO, RALPH A., SOLIS-HERRERA, CAROLINA
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 14.06.2024
• Subjects: Bioenergetics; Cardiac muscle; Diabetes; Diabetes mellitus (non-insulin dependent); Energy utilization; Ketones; Skeletal muscle

Background: SGLT2i is associated with CV benefits, but the mechanisms are not fully elucidated. We report a novel finding associated with improved CV Health in T2D & HFrEF. Elevated ketones, EF%, & heart remodeling have been reported with SGLT2i. This is likely, in part, due to a switch in c...