368-P: Type 2 Diabetes Mellitus Increases Epicardial Adipose Tissue Senescence in Subjects with Coronary Artery Disease during Elective Cardiac Surgery

• Published in: Diabetes (New York, N.Y.) Vol. 70; no. Supplement_1
• Main Authors: MRAZ, MILOS, TRNOVSKA, JAROSLAVA, KASPEROVA, BARBORA JUDITA, DVORAKOVA, IVETA, LACINOVA, ZDENKA, HLAVACEK, DANIEL, MAHRIK, JAKUB, IVAK, PETER, NETUKA, IVAN, HALUZIK, MARTIN
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 01.06.2021
• Subjects: Adipose tissue; Cardiovascular disease; Cardiovascular diseases; Coronary artery; Coronary artery disease; Coronary vessels; Cyclin-dependent kinase inhibitor p21; Diabetes; Diabetes mellitus (non-insulin dependent); Gene expression; Heart diseases; Heart surgery; Myocardium; Senescence

Cellular senescence is a novel mechanism suggested to contribute to the development of type 2 diabetes mellitus (T2DM) and cardiovascular diseases. Here, we analyzed the expression of senescent markers in myocardium and adjacent adipose tissue of subjects with and without coronary artery disease (CA...