Expression of leukemia inhibitory factor in the endometrium in abnormal uterine cavities during the implantation window
To investigate the expression of the implantation factors leukemia inhibitory factor (LIF), interleukin-11 (IL-11), and IL-6ST/gp130 in the endometrium to examine the relationship between loss of implantation and abnormal uterine cavity. Case-control study. Department of Obstetrics and Gynecology, T...
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| Published in | Fertility and sterility Vol. 97; no. 4; pp. 953 - 958 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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New York, NY
Elsevier Inc
01.04.2012
Elsevier |
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| Abstract | To investigate the expression of the implantation factors leukemia inhibitory factor (LIF), interleukin-11 (IL-11), and IL-6ST/gp130 in the endometrium to examine the relationship between loss of implantation and abnormal uterine cavity.
Case-control study.
Department of Obstetrics and Gynecology, Tokyo Medical University.
Subjects comprised 41 patients in the abnormal uterine cavity group who underwent resection of a uterine submucosal myoma or an endometrial polyp by transcervical resectoscopy (TCR) and 18 patients in the control group who underwent laparoscopic surgery.
In the abnormal uterine cavity group, endometrial tissue specimens were obtained before resection under hysteroscopy. In the control group, endometrial tissue specimens were obtained by curettage at the time of laparoscopic surgery.
We divided the patients into four groups according to menstrual cycle and measured the endometrial expression of LIF, IL-11, and IL-6ST/gp130 with the use of quantitative real-time reverse-transcription polymerase chain reaction.
Significant increases in LIF and IL-11 mRNA expression were recognized during the midsecretory phase of the menstrual cycle in the control group. However, no difference in IL-6ST/gp130 mRNA expression was observed in any phase during the menstrual cycle in either group. In terms of LIF and IL-11 mRNA expression at the midsecretory phase, the abnormal uterine cavity group showed a significantly decreased LIF mRNA expression compared with the control group.
LIF mRNA expression was significantly decreased in abnormal uterine cavities during the midsecretory phase, indicating that endometrial cavity defects are a possible cause of poor reproductive outcomes. |
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| AbstractList | To investigate the expression of the implantation factors leukemia inhibitory factor (LIF), interleukin-11 (IL-11), and IL-6ST/gp130 in the endometrium to examine the relationship between loss of implantation and abnormal uterine cavity.
Case-control study.
Department of Obstetrics and Gynecology, Tokyo Medical University.
Subjects comprised 41 patients in the abnormal uterine cavity group who underwent resection of a uterine submucosal myoma or an endometrial polyp by transcervical resectoscopy (TCR) and 18 patients in the control group who underwent laparoscopic surgery.
In the abnormal uterine cavity group, endometrial tissue specimens were obtained before resection under hysteroscopy. In the control group, endometrial tissue specimens were obtained by curettage at the time of laparoscopic surgery.
We divided the patients into four groups according to menstrual cycle and measured the endometrial expression of LIF, IL-11, and IL-6ST/gp130 with the use of quantitative real-time reverse-transcription polymerase chain reaction.
Significant increases in LIF and IL-11 mRNA expression were recognized during the midsecretory phase of the menstrual cycle in the control group. However, no difference in IL-6ST/gp130 mRNA expression was observed in any phase during the menstrual cycle in either group. In terms of LIF and IL-11 mRNA expression at the midsecretory phase, the abnormal uterine cavity group showed a significantly decreased LIF mRNA expression compared with the control group.
LIF mRNA expression was significantly decreased in abnormal uterine cavities during the midsecretory phase, indicating that endometrial cavity defects are a possible cause of poor reproductive outcomes. OBJECTIVE: To investigate the expression of the implantation factors leukemia inhibitory factor (LIF), interleukin-11 (IL-11), and IL-6ST/gp130 in the endometrium to examine the relationship between loss of implantation and abnormal uterine cavity. DESIGN: Case-control study. SETTING: Department of Obstetrics and Gynecology, Tokyo Medical University. PATIENT(S): Subjects comprised 41 patients in the abnormal uterine cavity group who underwent resection of a uterine submucosal myoma or an endometrial polyp by transcervical resectoscopy (TCR) and 18 patients in the control group who underwent laparoscopic surgery. INTERVENTION(S): In the abnormal uterine cavity group, endometrial tissue specimens were obtained before resection under hysteroscopy. In the control group, endometrial tissue specimens were obtained by curettage at the time of laparoscopic surgery. MAIN OUTCOME MEASUREMENT(S): We divided the patients into four groups according to menstrual cycle and measured the endometrial expression of LIF, IL-11, and IL-6ST/gp130 with the use of quantitative real-time reverse-transcription polymerase chain reaction. RESULT(S): Significant increases in LIF and IL-11 mRNA expression were recognized during the midsecretory phase of the menstrual cycle in the control group. However, no difference in IL-6ST/gp130 mRNA expression was observed in any phase during the menstrual cycle in either group. In terms of LIF and IL-11 mRNA expression at the midsecretory phase, the abnormal uterine cavity group showed a significantly decreased LIF mRNA expression compared with the control group. CONCLUSION(S): LIF mRNA expression was significantly decreased in abnormal uterine cavities during the midsecretory phase, indicating that endometrial cavity defects are a possible cause of poor reproductive outcomes. To investigate the expression of the implantation factors leukemia inhibitory factor (LIF), interleukin-11 (IL-11), and IL-6ST/gp130 in the endometrium to examine the relationship between loss of implantation and abnormal uterine cavity.OBJECTIVETo investigate the expression of the implantation factors leukemia inhibitory factor (LIF), interleukin-11 (IL-11), and IL-6ST/gp130 in the endometrium to examine the relationship between loss of implantation and abnormal uterine cavity.Case-control study.DESIGNCase-control study.Department of Obstetrics and Gynecology, Tokyo Medical University.SETTINGDepartment of Obstetrics and Gynecology, Tokyo Medical University.Subjects comprised 41 patients in the abnormal uterine cavity group who underwent resection of a uterine submucosal myoma or an endometrial polyp by transcervical resectoscopy (TCR) and 18 patients in the control group who underwent laparoscopic surgery.PATIENT(S)Subjects comprised 41 patients in the abnormal uterine cavity group who underwent resection of a uterine submucosal myoma or an endometrial polyp by transcervical resectoscopy (TCR) and 18 patients in the control group who underwent laparoscopic surgery.In the abnormal uterine cavity group, endometrial tissue specimens were obtained before resection under hysteroscopy. In the control group, endometrial tissue specimens were obtained by curettage at the time of laparoscopic surgery.INTERVENTION(S)In the abnormal uterine cavity group, endometrial tissue specimens were obtained before resection under hysteroscopy. In the control group, endometrial tissue specimens were obtained by curettage at the time of laparoscopic surgery.We divided the patients into four groups according to menstrual cycle and measured the endometrial expression of LIF, IL-11, and IL-6ST/gp130 with the use of quantitative real-time reverse-transcription polymerase chain reaction.MAIN OUTCOME MEASUREMENT(S)We divided the patients into four groups according to menstrual cycle and measured the endometrial expression of LIF, IL-11, and IL-6ST/gp130 with the use of quantitative real-time reverse-transcription polymerase chain reaction.Significant increases in LIF and IL-11 mRNA expression were recognized during the midsecretory phase of the menstrual cycle in the control group. However, no difference in IL-6ST/gp130 mRNA expression was observed in any phase during the menstrual cycle in either group. In terms of LIF and IL-11 mRNA expression at the midsecretory phase, the abnormal uterine cavity group showed a significantly decreased LIF mRNA expression compared with the control group.RESULT(S)Significant increases in LIF and IL-11 mRNA expression were recognized during the midsecretory phase of the menstrual cycle in the control group. However, no difference in IL-6ST/gp130 mRNA expression was observed in any phase during the menstrual cycle in either group. In terms of LIF and IL-11 mRNA expression at the midsecretory phase, the abnormal uterine cavity group showed a significantly decreased LIF mRNA expression compared with the control group.LIF mRNA expression was significantly decreased in abnormal uterine cavities during the midsecretory phase, indicating that endometrial cavity defects are a possible cause of poor reproductive outcomes.CONCLUSION(S)LIF mRNA expression was significantly decreased in abnormal uterine cavities during the midsecretory phase, indicating that endometrial cavity defects are a possible cause of poor reproductive outcomes. |
| Author | Usuda, Saburo Hasegawa, Fumiko Ito, Hiroe Hasegawa, Ei Isaka, Keiichi Hatano, Keiko Kazuka, Masahiro |
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| Cites_doi | 10.1530/JOE-10-0461 10.1210/er.2003-0020 10.1186/1477-7827-3-20 10.1053/beog.2000.0121 10.1016/j.fertnstert.2008.03.029 10.1093/molehr/gah107 10.1006/dbio.2000.9767 10.1111/j.1749-6632.1994.tb21743.x 10.1038/359076a0 10.1093/molehr/6.10.907 10.1093/HUMREP/10.6.1579 10.1016/S0015-0282(16)45789-4 10.1530/jrf.0.1010421 10.1093/humrep/del225 10.1016/j.jri.2004.08.007 10.1016/S0165-0378(00)00089-9 10.1016/j.fertnstert.2009.03.075 10.1093/oxfordjournals.humrep.a136328 10.1159/000084513 10.1139/o92-135 10.1242/dev.121.5.1283 10.1016/0968-0004(92)90505-4 10.1186/1477-7827-7-30 10.1016/j.rbmo.2009.06.011 |
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| Copyright | 2012 American Society for Reproductive Medicine American Society for Reproductive Medicine 2015 INIST-CNRS Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
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| Keywords | Leukemia inhibitory factor (LIF) endometrial polyp implantation window submucosal myoma endometrial receptivity Myoma Leukemia inhibitory factor Gynecology Implantation Obstetrics Female genital diseases Cavity Uterus Uterine diseases Submucosa Endometrium Polyp |
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| Snippet | To investigate the expression of the implantation factors leukemia inhibitory factor (LIF), interleukin-11 (IL-11), and IL-6ST/gp130 in the endometrium to... Objective To investigate the expression of the implantation factors leukemia inhibitory factor (LIF), interleukin-11 (IL-11), and IL-6ST/gp130 in the... OBJECTIVE: To investigate the expression of the implantation factors leukemia inhibitory factor (LIF), interleukin-11 (IL-11), and IL-6ST/gp130 in the... |
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| SubjectTerms | Adult Biological and medical sciences Case-Control Studies Cytokine Receptor gp130 - genetics Embryo Implantation endometrial polyp endometrial receptivity endometrium Endometrium - metabolism Female gene expression Gynecology. Andrology. Obstetrics Humans Hysteroscopy implantation window interleukin-11 Interleukin-11 - genetics Internal Medicine Japan laparoscopy Leiomyoma - genetics Leiomyoma - pathology Leiomyoma - surgery leukemia inhibitory factor Leukemia inhibitory factor (LIF) Leukemia Inhibitory Factor - genetics Medical sciences menstrual cycle Menstrual Cycle - genetics messenger RNA Obstetrics and Gynecology patients Polyps - genetics Polyps - pathology Polyps - surgery Real-Time Polymerase Chain Reaction resection Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism submucosal myoma Uterine Neoplasms - genetics Uterine Neoplasms - pathology Uterine Neoplasms - surgery Uterus - metabolism Uterus - pathology Uterus - surgery |
| Title | Expression of leukemia inhibitory factor in the endometrium in abnormal uterine cavities during the implantation window |
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