Role of serine/threonine protein phosphatase PrpN in the life cycle of Bacillus anthracis

Reversible protein phosphorylation at serine/threonine residues is one of the most common protein modifications, widely observed in all kingdoms of life. The catalysts controlling this modification are specific serine/threonine kinases and phosphatases that modulate various cellular pathways ranging...

Full description

Saved in:
Bibliographic Details
Published inPLoS pathogens Vol. 18; no. 8; p. e1010729
Main Authors Gangwal, Aakriti, Sangwan, Nitika, Dhasmana, Neha, Kumar, Nishant, Keshavam, Chetkar Chandra, Singh, Lalit K, Bothra, Ankur, Goel, Ajay K, Pomerantsev, Andrei P, Leppla, Stephen H, Singh, Yogendra
Format Journal Article
LanguageEnglish
Published San Francisco Public Library of Science 01.08.2022
Public Library of Science (PLoS)
Subjects
Anthrax
Bacillus anthracis
Bacterial proteins
Binding sites
Biology and Life Sciences
Catalysts
Cell death
Chemical properties
Edema
Enzyme kinetics
Gene sequencing
Genes
Genomes
Glycerol
Growth
Kinases
Life cycles
Medicine and Health Sciences
Mutants
Pathogens
Phosphatase
Phosphatases
Phosphorylation
Physiological aspects
Physiology
Plasmids
Prokaryotes
Protein kinases
Protein phosphatase
Protein-serine/threonine kinase
Proteins
Regulation
Serine
Sporulation
Streptococcus infections
Structure-function relationships
Synthesis
Threonine
Toxins
Virulence
United States
Online AccessGet full text

Cover

Abstract Reversible protein phosphorylation at serine/threonine residues is one of the most common protein modifications, widely observed in all kingdoms of life. The catalysts controlling this modification are specific serine/threonine kinases and phosphatases that modulate various cellular pathways ranging from growth to cellular death. Genome sequencing and various omics studies have led to the identification of numerous serine/threonine kinases and cognate phosphatases, yet the physiological relevance of many of these proteins remain enigmatic. In Bacillus anthracis , only one ser/thr phosphatase, PrpC, has been functionally characterized; it was reported to be non-essential for bacterial growth and survival. In the present study, we characterized another ser/thr phosphatase (PrpN) of B . anthracis by various structural and functional approaches. To examine its physiological relevance in B . anthracis , a null mutant strain of prpN was generated and shown to have defects in sporulation and reduced synthesis of toxins (PA and LF) and the toxin activator protein AtxA. We also identified CodY, a global transcriptional regulator, as a target of PrpN and ser/thr kinase PrkC. CodY phosphorylation strongly controlled its binding to the promoter region of atxA , as shown using phosphomimetic and phosphoablative mutants. In nutshell, the present study reports phosphorylation-mediated regulation of CodY activity in the context of anthrax toxin synthesis in B . anthracis by a previously uncharacterized ser/thr protein phosphatase–PrpN.
AbstractList Reversible protein phosphorylation at serine/threonine residues is one of the most common protein modifications, widely observed in all kingdoms of life. The catalysts controlling this modification are specific serine/threonine kinases and phosphatases that modulate various cellular pathways ranging from growth to cellular death. Genome sequencing and various omics studies have led to the identification of numerous serine/threonine kinases and cognate phosphatases, yet the physiological relevance of many of these proteins remain enigmatic. In Bacillus anthracis , only one ser/thr phosphatase, PrpC, has been functionally characterized; it was reported to be non-essential for bacterial growth and survival. In the present study, we characterized another ser/thr phosphatase (PrpN) of B . anthracis by various structural and functional approaches. To examine its physiological relevance in B . anthracis , a null mutant strain of prpN was generated and shown to have defects in sporulation and reduced synthesis of toxins (PA and LF) and the toxin activator protein AtxA. We also identified CodY, a global transcriptional regulator, as a target of PrpN and ser/thr kinase PrkC. CodY phosphorylation strongly controlled its binding to the promoter region of atxA , as shown using phosphomimetic and phosphoablative mutants. In nutshell, the present study reports phosphorylation-mediated regulation of CodY activity in the context of anthrax toxin synthesis in B . anthracis by a previously uncharacterized ser/thr protein phosphatase–PrpN.
Reversible protein phosphorylation at serine/threonine residues is one of the most common protein modifications, widely observed in all kingdoms of life. The catalysts controlling this modification are specific serine/threonine kinases and phosphatases that modulate various cellular pathways ranging from growth to cellular death. Genome sequencing and various omics studies have led to the identification of numerous serine/threonine kinases and cognate phosphatases, yet the physiological relevance of many of these proteins remain enigmatic. In Bacillus anthracis, only one ser/thr phosphatase, PrpC, has been functionally characterized; it was reported to be non-essential for bacterial growth and survival. In the present study, we characterized another ser/thr phosphatase (PrpN) of B. anthracis by various structural and functional approaches. To examine its physiological relevance in B. anthracis, a null mutant strain of prpN was generated and shown to have defects in sporulation and reduced synthesis of toxins (PA and LF) and the toxin activator protein AtxA. We also identified CodY, a global transcriptional regulator, as a target of PrpN and ser/thr kinase PrkC. CodY phosphorylation strongly controlled its binding to the promoter region of atxA, as shown using phosphomimetic and phosphoablative mutants. In nutshell, the present study reports phosphorylation-mediated regulation of CodY activity in the context of anthrax toxin synthesis in B. anthracis by a previously uncharacterized ser/thr protein phosphatase–PrpN.
Reversible protein phosphorylation at serine/threonine residues is one of the most common protein modifications, widely observed in all kingdoms of life. The catalysts controlling this modification are specific serine/threonine kinases and phosphatases that modulate various cellular pathways ranging from growth to cellular death. Genome sequencing and various omics studies have led to the identification of numerous serine/threonine kinases and cognate phosphatases, yet the physiological relevance of many of these proteins remain enigmatic. In Bacillus anthracis , only one ser/thr phosphatase, PrpC, has been functionally characterized; it was reported to be non-essential for bacterial growth and survival. In the present study, we characterized another ser/thr phosphatase (PrpN) of B . anthracis by various structural and functional approaches. To examine its physiological relevance in B . anthracis , a null mutant strain of prpN was generated and shown to have defects in sporulation and reduced synthesis of toxins (PA and LF) and the toxin activator protein AtxA. We also identified CodY, a global transcriptional regulator, as a target of PrpN and ser/thr kinase PrkC. CodY phosphorylation strongly controlled its binding to the promoter region of atxA , as shown using phosphomimetic and phosphoablative mutants. In nutshell, the present study reports phosphorylation-mediated regulation of CodY activity in the context of anthrax toxin synthesis in B . anthracis by a previously uncharacterized ser/thr protein phosphatase–PrpN. Reversible protein phosphorylation at specific ser/thr residues causes conformational changes in the protein structure, thereby modulating its cellular activity. In B . anthracis , though the role of ser/thr phosphorylation is implicated in various cellular pathways including pathogenesis, till date only one STP (PrpC) has been functionally characterized. This manuscript reports functional characterization of another STP (PrpN) in B . anthracis and with the aid of a null mutant strain (BAS Δ prpN ) we provide important insight regarding the role of PrpN in the life cycle of B . anthracis . We have also identified the global transcriptional regulator, CodY as a target of PrpN and PrkC, and for the first time showed the physiological relevance of CodY phosphorylation status in the regulation of anthrax toxin synthesis.
Audience Academic
Author Singh, Lalit K
Bothra, Ankur
Leppla, Stephen H
Kumar, Nishant
Gangwal, Aakriti
Sangwan, Nitika
Keshavam, Chetkar Chandra
Pomerantsev, Andrei P
Dhasmana, Neha
Goel, Ajay K
Singh, Yogendra
AuthorAffiliation 4 Division of Biotechnology, Defence Research and Development Establishment, Gwalior, Madhya Pradesh, India
1 Department of Zoology, University of Delhi, Delhi, India
3 Microbial Pathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
2 CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi, India
University of Texas Medical School at Houston, UNITED STATES
AuthorAffiliation_xml – name: 2 CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi, India
– name: 1 Department of Zoology, University of Delhi, Delhi, India
– name: 4 Division of Biotechnology, Defence Research and Development Establishment, Gwalior, Madhya Pradesh, India
– name: 3 Microbial Pathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
– name: University of Texas Medical School at Houston, UNITED STATES
Author_xml – sequence: 1
  fullname: Gangwal, Aakriti
– sequence: 2
  fullname: Sangwan, Nitika
– sequence: 3
  fullname: Dhasmana, Neha
– sequence: 4
  fullname: Kumar, Nishant
– sequence: 5
  fullname: Keshavam, Chetkar Chandra
– sequence: 6
  fullname: Singh, Lalit K
– sequence: 7
  fullname: Bothra, Ankur
– sequence: 8
  fullname: Goel, Ajay K
– sequence: 9
  fullname: Pomerantsev, Andrei P
– sequence: 10
  fullname: Leppla, Stephen H
– sequence: 11
  fullname: Singh, Yogendra
BookMark eNqVkkuPFCEQxztmjfvQb2BiJ170MLM8uhu4mKwbH5NsVrPqwRMBuphh0wMt0Mb99jJOaxyzF8OBovjVv6iiTqsjHzxU1VOMlpgyfH4bpujVsBxHlZcYYcSIeFCd4LalC0ZZc_SXfVydpnSLUIMp7h5Vx7QVmApBT6qvN2GAOtg6QXQezvMmQvDFqscYMjhfj5uQxo3KKkH9MY7XdfHlDdSDs1CbO7MPf62MG4Yp1coXiXJIj6uHVg0Jnsz7WfXl7ZvPl-8XVx_erS4vrhamozwvTMs4FVgx6DttO8N1a3vSg7Ba645QobTmjEOPjBa9JoYTBZS3GHELTQHOqmd73XEISc5dSZIw3OKGNIIXYrUn-qBu5RjdVsU7GZSTvxwhrqWK2ZVKpLB9q0iDlSC4EbpXje0x1pwTphkDXbRezdkmvYXegM9RDQeihzfebeQ6fJei_Bnp2iLwYhaI4dsEKcutSwaGQXkIU3l3JxgSBDFW0Of_oPdXN1NrVQpw3oaS1-xE5UWhSt4GoUIt76HK6mHrTJks64r_IODlQUBhMvzIazWlJFefbv6DvT5kmz1rYkgpgv3TO4zkbrB_Fyl3gy3nwaY_AYzT7I0
CitedBy_id crossref_primary_10_1093_femsre_fuad044
crossref_primary_10_1111_mmi_15220
Cites_doi 10.1038/nrmicro750
10.1128/IAI.00716-09
10.1074/jbc.RA118.005424
10.1128/JB.01115-07
10.1128/JB.186.2.307-315.2004
10.1371/journal.pone.0006532
10.1164/rccm.201102-0209CI
10.1111/j.1574-6976.2011.00310.x
10.1111/mmi.12617
10.1128/JB.00723-06
10.1146/annurev-micro-091014-104523
10.1128/JB.184.2.370-380.2002
10.1007/s12088-021-00927-5
10.1128/IAI.00530-08
10.1146/annurev-micro-020415-111342
10.1128/JB.00963-06
10.1074/jbc.M112.351304
10.1128/iai.45.3.761-767.1984
10.1128/JB.185.6.1911-1922.2003
10.1128/IAI.00884-19
10.3389/fmicb.2016.00184
10.1016/j.pharmthera.2020.107622
10.1016/j.cellsig.2014.06.013
10.1111/j.1462-2920.2012.02766.x
10.1111/j.1742-4658.2012.08609.x
10.21769/BioProtoc.970
10.1007/s12088-018-0744-y
10.1074/jbc.M116.754309
10.1074/mcp.M600464-MCP200
10.3389/fmicb.2018.00482
10.1038/s41598-020-74609-5
10.1074/jbc.M116.754531
10.1016/j.molbiopara.2008.06.008
10.1111/1462-2920.12548
10.1128/JB.01625-14
10.1038/s41564-019-0648-6
10.1074/jbc.M111.313486
10.1093/femspd/ftx048
10.1186/s12864-016-3004-8
10.1128/JB.00569-19
10.1128/MMBR.64.3.503-514.2000
10.1006/scbi.1995.0028
10.1111/j.1472-765X.2012.03209.x
10.1128/AEM.72.1.937-941.2006
10.1111/mmi.12233
10.1128/JB.02041-12
10.1128/jb.176.16.5188-5192.1994
10.1099/mic.0.27803-0
10.1096/fj.11-188912
10.1128/AEM.01781-06
10.1086/382656
10.3389/fmicb.2016.00568
10.1016/S0021-9258(18)76142-5
10.1016/j.mib.2015.01.005
10.20506/rst.21.2.1336
10.15698/mic2019.05.677
10.1111/j.1365-2958.2010.07182.x
10.1099/mic.0.000148
10.1038/s41579-019-0243-0
10.1128/JB.184.22.6109-6114.2002
10.1093/infdis/jiw098
10.1111/j.1365-2958.2009.07041.x
10.1016/j.mib.2019.12.002
10.1038/s41564-019-0435-4
10.1016/j.resmic.2010.09.006
10.1186/s12915-015-0184-7
10.1146/annurev.micro.55.1.647
10.1038/nrmicro1205
10.1128/MMBR.00031-15
10.1016/j.bbrc.2015.12.019
10.3389/fmicb.2018.00486
10.1128/microbiolspec.VMBF-0029-2015
10.1111/j.1574-695X.2011.00812.x
10.12998/wjcc.v3.i1.20
10.1128/jb.175.17.5329-5338.1993
10.1016/j.bbapap.2009.09.008
10.3390/toxins12070464
10.1371/journal.pone.0084947
10.1111/j.1365-2958.2004.04135.x
10.1038/s41522-017-0015-4
10.1007/s00284-016-1120-y
10.1128/JB.01221-09
10.1128/JB.00422-09
10.1111/febs.15454
10.1038/170804b0
10.1128/iai.39.1.371-376.1983
10.1371/journal.pone.0184975
10.1128/JB.01401-10
10.1007/s10534-013-9646-y
10.1146/annurev.cellbio.19.111301.140655
10.1074/jbc.R114.557926
10.1016/S0021-9258(19)47273-6
10.1371/journal.ppat.1003027
10.1146/annurev-micro-102215-095331
10.1128/JB.187.12.4127-4139.2005
10.1038/srep18908
10.1016/j.mam.2009.08.004
10.1016/j.micres.2014.05.001
10.1111/j.1365-2958.1995.tb02340.x
10.1126/science.34215
10.2174/138920312804871201
10.1128/JB.181.20.6509-6515.1999
ContentType Journal Article
Copyright COPYRIGHT 2022 Public Library of Science
This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: COPYRIGHT 2022 Public Library of Science
– notice: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID AAYXX
CITATION
ISN
ISR
3V.
7QL
7U9
7X7
7XB
88E
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
C1K
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
DOA
DOI 10.1371/journal.ppat.1010729
DatabaseName CrossRef
Gale In Context: Canada
Gale In Context: Science
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Virology and AIDS Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni Edition)
Medical Database
Biological Science Database
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
Publicly Available Content Database
ProQuest Central Student
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest Central
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Biological Science Collection
AIDS and Cancer Research Abstracts
ProQuest Medical Library (Alumni)
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList CrossRef



Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
DocumentTitleAlternate PrpN regulates toxin synthesis in B. anthracis
EISSN 1553-7374
Editor Koehler, Theresa M.
Editor_xml – sequence: 1
  givenname: Theresa M.
  surname: Koehler
  fullname: Koehler, Theresa M.
EndPage e1010729
ExternalDocumentID 2715142498
oai_doaj_org_article_9fd5a241a92149bda4fd11b8827b77eb
A715937400
10_1371_journal_ppat_1010729
GeographicLocations United States
GeographicLocations_xml – name: United States
GrantInformation_xml – fundername: ;
  grantid: CRG/2018/000847/HS
– fundername: ;
– fundername: ;
  grantid: SB/S2/JCB-012/2015
GroupedDBID ---
123
29O
2WC
3V.
53G
5VS
7X7
88E
8FE
8FH
8FI
8FJ
AAFWJ
AAYXX
ABDBF
ABUWG
ACGFO
ACIHN
ACPRK
ADBBV
AEAQA
AENEX
AFKRA
AFPKN
AFRAH
AHMBA
ALMA_UNASSIGNED_HOLDINGS
AOIJS
B0M
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
BWKFM
CCPQU
CITATION
CS3
DIK
DU5
E3Z
EAP
EAS
EBD
EMK
EMOBN
ESX
F5P
FPL
FYUFA
GROUPED_DOAJ
GX1
HCIFZ
HMCUK
HYE
IAO
IHR
INH
INR
ISN
ISR
ITC
KQ8
LK8
M1P
M48
M7P
MM.
M~E
O5R
O5S
OK1
P2P
PGMZT
PIMPY
PQQKQ
PROAC
PSQYO
PV9
QF4
QN7
RNS
RPM
RZL
SV3
TR2
TUS
UKHRP
WOW
~8M
7QL
7U9
7XB
8FK
AZQEC
C1K
DWQXO
GNUQQ
H94
K9.
PQEST
PQUKI
PRINS
7X8
5PM
AAPBV
ABPTK
ID FETCH-LOGICAL-c638t-c578391a7ed6bf6c8b5fd2de9fbbb6239abb878ed0cb9db2c82ae385108fe4623
IEDL.DBID RPM
ISSN 1553-7374
1553-7366
IngestDate Sun Sep 03 00:14:44 EDT 2023
Tue Oct 22 15:16:54 EDT 2024
Tue Sep 17 20:49:38 EDT 2024
Fri Aug 16 22:13:45 EDT 2024
Thu Oct 10 18:08:53 EDT 2024
Thu Feb 22 23:37:15 EST 2024
Fri Feb 02 04:33:26 EST 2024
Thu Aug 01 20:00:52 EDT 2024
Thu Aug 01 19:57:54 EDT 2024
Fri Aug 23 01:31:12 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 8
Language English
License This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
Creative Commons CC0 public domain
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c638t-c578391a7ed6bf6c8b5fd2de9fbbb6239abb878ed0cb9db2c82ae385108fe4623
Notes new_version
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
The authors have declared that no competing interests exist.
Current address: InVitaGO Diagnostic GmbH, Frankfurt am Main, Germany.
ORCID 0000-0001-7828-4427
0000-0002-3902-4355
0000-0001-5233-0501
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371265/
PMID 35913993
PQID 2715142498
PQPubID 1436335
PageCount e1010729
ParticipantIDs plos_journals_2715142498
doaj_primary_oai_doaj_org_article_9fd5a241a92149bda4fd11b8827b77eb
pubmedcentral_primary_oai_pubmedcentral_nih_gov_9371265
proquest_miscellaneous_2697092077
proquest_journals_2715142498
gale_infotracmisc_A715937400
gale_infotracacademiconefile_A715937400
gale_incontextgauss_ISR_A715937400
gale_incontextgauss_ISN_A715937400
crossref_primary_10_1371_journal_ppat_1010729
PublicationCentury 2000
PublicationDate 2022-8-1
20220801
2022-08-01
PublicationDateYYYYMMDD 2022-08-01
PublicationDate_xml – month: 08
  year: 2022
  text: 20220801
  day: 01
PublicationDecade 2020
PublicationPlace San Francisco
PublicationPlace_xml – name: San Francisco
– name: San Francisco, CA USA
PublicationTitle PLoS pathogens
PublicationYear 2022
Publisher Public Library of Science
Public Library of Science (PLoS)
Publisher_xml – name: Public Library of Science
– name: Public Library of Science (PLoS)
References VM Levdikov (ppat.1010729.ref076) 2017; 292
A Chateau (ppat.1010729.ref073) 2011; 25
A Sajid (ppat.1010729.ref090) 2015; 69
J Deutscher (ppat.1010729.ref032) 2005; 9
ME Hugh-Jones (ppat.1010729.ref002) 2002; 21
Z Dai (ppat.1010729.ref026) 1995; 16
F Pompeo (ppat.1010729.ref059) 2016; 7
W Beyer (ppat.1010729.ref003) 2009; 30
SC Iyer (ppat.1010729.ref095) 2020; 5
A Kobir (ppat.1010729.ref099) 2014; 92
DA Sweeney (ppat.1010729.ref013) 2011; 184
LK Singh (ppat.1010729.ref106) 2015; 17
NH Bergman (ppat.1010729.ref006) 2006; 188
Q Chen (ppat.1010729.ref105) 2013; 3
R Virmani (ppat.1010729.ref040) 2018; 58
R Schuch (ppat.1010729.ref005) 2009; 4
VI Patel (ppat.1010729.ref018) 2020; 12
CH De Verdier (ppat.1010729.ref037) 1952; 170
JL Dale (ppat.1010729.ref027) 2018; 9
MA Strauch (ppat.1010729.ref028) 2005; 151
SR Sella (ppat.1010729.ref066) 2014; 169
RT Okinaka (ppat.1010729.ref016) 1999; 181
P Joseph (ppat.1010729.ref075) 2005; 187
T Garcia-Garcia (ppat.1010729.ref034) 2016; 7
L Stenz (ppat.1010729.ref102) 2011; 62
AK Sharma (ppat.1010729.ref092) 2016; 291
RP Shivers (ppat.1010729.ref079) 2004; 53
A Ruggiero (ppat.1010729.ref048) 2012; 13
MT Cabeen (ppat.1010729.ref056) 2005; 3
MC Swick (ppat.1010729.ref009) 2016; 4
G Jouvion (ppat.1010729.ref011) 2016; 214
Walther (ppat.1010729.ref058) 2010; 123
R Kamada (ppat.1010729.ref084) 2020; 215
J Skoble (ppat.1010729.ref068) 2009; 77
RJ Collier (ppat.1010729.ref017) 2003; 19
A. Fouet (ppat.1010729.ref022) 2010; 161
J Chao (ppat.1010729.ref082) 2010; 1804
P Mikesell (ppat.1010729.ref014) 1983; 39
N Dhasmana (ppat.1010729.ref041) 2021
KM Bryant-Hudson (ppat.1010729.ref044) 2011; 193
S Joon (ppat.1010729.ref098) 2017; 75
M Garnak (ppat.1010729.ref035) 1979; 203
SA McPherson (ppat.1010729.ref046) 2010; 76
W van Schaik (ppat.1010729.ref030) 2009; 77
NR Salama (ppat.1010729.ref052) 2020; 54
L Wang (ppat.1010729.ref053) 2012; 8
TA Gaidenko (ppat.1010729.ref093) 2002; 184
G Ruthel (ppat.1010729.ref004) 2004; 189
A Chateau (ppat.1010729.ref029) 2013; 195
M Mock (ppat.1010729.ref008) 2001; 55
Y Singh (ppat.1010729.ref103) 1989; 264
C Matta (ppat.1010729.ref088) 2014; 26
E Huillet (ppat.1010729.ref100) 2017; 12
FA Lipmann (ppat.1010729.ref036) 1932; 98
G Arora (ppat.1010729.ref042) 2013; 26
M Bheri (ppat.1010729.ref089) 2021; 288
DL Brautigan (ppat.1010729.ref086) 2013; 280
I Uchida (ppat.1010729.ref025) 1993; 175
SK Kim (ppat.1010729.ref071) 2016; 17
A Rosenberg (ppat.1010729.ref060) 2015; 13
J. Dworkin (ppat.1010729.ref083) 2015; 24
R Virmani (ppat.1010729.ref039) 2019; 294
G Boel (ppat.1010729.ref096) 2003; 5
JC Sirard (ppat.1010729.ref019) 1994; 176
D Higgins (ppat.1010729.ref007) 2012; 36
S Auger (ppat.1010729.ref109) 2006; 72
RM McCall (ppat.1010729.ref024) 2019; 201
EA Groisman (ppat.1010729.ref097) 2016; 70
LD Handke (ppat.1010729.ref077) 2008; 190
JW Ezzell (ppat.1010729.ref021) 1984; 45
M Drysdale (ppat.1010729.ref023) 2004; 186
AP Pomerantsev (ppat.1010729.ref047) 2009; 191
V Bidnenko (ppat.1010729.ref062) 2013; 88
SM Shakir (ppat.1010729.ref045) 2010; 192
M Moayeri (ppat.1010729.ref010) 2015; 69
JG Wijman (ppat.1010729.ref108) 2007; 73
AJ Cozzone (ppat.1010729.ref033) 2005; 9
J. Errington (ppat.1010729.ref064) 2003; 1
T Chitlaru (ppat.1010729.ref069) 2016; 6
AK Goel (ppat.1010729.ref057) 2015; 3
V Molle (ppat.1010729.ref078) 2003; 185
MA Kutuzov (ppat.1010729.ref087) 2008; 161
J Yan (ppat.1010729.ref061) 2015; 6
G Iosifidis (ppat.1010729.ref051) 2020; 88
G Arora (ppat.1010729.ref038) 2017; 3
J Sassine (ppat.1010729.ref055) 2020; 10
B Macek (ppat.1010729.ref074) 2007; 6
I Uchida (ppat.1010729.ref015) 1986; 132
B Macek (ppat.1010729.ref080) 2019; 17
H Levy (ppat.1010729.ref012) 2014; 9
M Gupta (ppat.1010729.ref104) 2014; 196
M Gopalani (ppat.1010729.ref072) 2016; 469
DC Yang (ppat.1010729.ref054) 2016; 80
K. Lewis (ppat.1010729.ref065) 2000; 64
A Kalantari (ppat.1010729.ref094) 2015; 161
N Kumar (ppat.1010729.ref107) 2021; 61
V Molle (ppat.1010729.ref049) 2010; 75
SK Kim (ppat.1010729.ref070) 2016; 73
CJ Carlson (ppat.1010729.ref001) 2019; 4
E Saile (ppat.1010729.ref020) 2002; 184
G Arora (ppat.1010729.ref043) 2012; 287
K Burnside (ppat.1010729.ref081) 2011; 286
J Arino (ppat.1010729.ref085) 2019; 6
JM Kyriakis (ppat.1010729.ref031) 2014; 289
P Fernandez (ppat.1010729.ref050) 2006; 188
SK Kim (ppat.1010729.ref067) 2012; 54
T Garcia Garcia (ppat.1010729.ref063) 2018; 9
DL Brautigan (ppat.1010729.ref091) 1995; 6
T Lindback (ppat.1010729.ref101) 2012; 14
References_xml – volume: 1
  start-page: 117
  issue: 2
  year: 2003
  ident: ppat.1010729.ref064
  article-title: Regulation of endospore formation in Bacillus subtilis
  publication-title: Nat Rev Microbiol
  doi: 10.1038/nrmicro750
  contributor:
    fullname: J. Errington
– volume: 77
  start-page: 4437
  issue: 10
  year: 2009
  ident: ppat.1010729.ref030
  article-title: The global regulator CodY regulates toxin gene expression in Bacillus anthracis and is required for full virulence
  publication-title: Infect Immun
  doi: 10.1128/IAI.00716-09
  contributor:
    fullname: W van Schaik
– volume: 294
  start-page: 8930
  issue: 22
  year: 2019
  ident: ppat.1010729.ref039
  article-title: The Ser/Thr protein kinase PrkC imprints phenotypic memory in Bacillus anthracis spores by phosphorylating the glycolytic enzyme enolase
  publication-title: J Biol Chem
  doi: 10.1074/jbc.RA118.005424
  contributor:
    fullname: R Virmani
– volume: 190
  start-page: 798
  issue: 3
  year: 2008
  ident: ppat.1010729.ref077
  article-title: Interaction of Bacillus subtilis CodY with GTP
  publication-title: J Bacteriol
  doi: 10.1128/JB.01115-07
  contributor:
    fullname: LD Handke
– volume: 186
  start-page: 307
  issue: 2
  year: 2004
  ident: ppat.1010729.ref023
  article-title: atxA controls Bacillus anthracis capsule synthesis via acpA and a newly discovered regulator, acpB
  publication-title: J Bacteriol
  doi: 10.1128/JB.186.2.307-315.2004
  contributor:
    fullname: M Drysdale
– volume: 4
  start-page: e6532
  issue: 8
  year: 2009
  ident: ppat.1010729.ref005
  article-title: The secret life of the anthrax agent Bacillus anthracis: bacteriophage-mediated ecological adaptations
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0006532
  contributor:
    fullname: R Schuch
– volume: 184
  start-page: 1333
  issue: 12
  year: 2011
  ident: ppat.1010729.ref013
  article-title: Anthrax infection
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.201102-0209CI
  contributor:
    fullname: DA Sweeney
– volume: 36
  start-page: 131
  issue: 1
  year: 2012
  ident: ppat.1010729.ref007
  article-title: Recent progress in Bacillus subtilis sporulation
  publication-title: FEMS Microbiol Rev
  doi: 10.1111/j.1574-6976.2011.00310.x
  contributor:
    fullname: D Higgins
– volume: 92
  start-page: 1129
  issue: 5
  year: 2014
  ident: ppat.1010729.ref099
  article-title: Phosphorylation of Bacillus subtilis gene regulator AbrB modulates its DNA-binding properties
  publication-title: Mol Microbiol
  doi: 10.1111/mmi.12617
  contributor:
    fullname: A Kobir
– volume: 188
  start-page: 6092
  issue: 17
  year: 2006
  ident: ppat.1010729.ref006
  article-title: Transcriptional profiling of the Bacillus anthracis life cycle in vitro and an implied model for regulation of spore formation
  publication-title: J Bacteriol
  doi: 10.1128/JB.00723-06
  contributor:
    fullname: NH Bergman
– volume: 69
  start-page: 185
  year: 2015
  ident: ppat.1010729.ref010
  article-title: Anthrax Pathogenesis
  publication-title: Annu Rev Microbiol
  doi: 10.1146/annurev-micro-091014-104523
  contributor:
    fullname: M Moayeri
– volume: 184
  start-page: 370
  issue: 2
  year: 2002
  ident: ppat.1010729.ref020
  article-title: Control of anthrax toxin gene expression by the transition state regulator abrB
  publication-title: J Bacteriol
  doi: 10.1128/JB.184.2.370-380.2002
  contributor:
    fullname: E Saile
– volume: 61
  start-page: 170
  issue: 2
  year: 2021
  ident: ppat.1010729.ref107
  article-title: ClpC-Mediated Sporulation Regulation at Engulfment Stage in Bacillus anthracis
  publication-title: Indian J Microbiol
  doi: 10.1007/s12088-021-00927-5
  contributor:
    fullname: N Kumar
– volume: 77
  start-page: 1649
  issue: 4
  year: 2009
  ident: ppat.1010729.ref068
  article-title: Killed but metabolically active Bacillus anthracis vaccines induce broad and protective immunity against anthrax
  publication-title: Infect Immun
  doi: 10.1128/IAI.00530-08
  contributor:
    fullname: J Skoble
– volume: 9
  start-page: 125
  issue: 3–4
  year: 2005
  ident: ppat.1010729.ref032
  article-title: Ser/Thr/Tyr protein phosphorylation in bacteria—for long time neglected, now well established
  publication-title: J Mol Microbiol Biotechnol
  contributor:
    fullname: J Deutscher
– volume: 69
  start-page: 527
  year: 2015
  ident: ppat.1010729.ref090
  article-title: Protein Phosphatases of Pathogenic Bacteria: Role in Physiology and Virulence
  publication-title: Annu Rev Microbiol
  doi: 10.1146/annurev-micro-020415-111342
  contributor:
    fullname: A Sajid
– volume: 188
  start-page: 7778
  issue: 22
  year: 2006
  ident: ppat.1010729.ref050
  article-title: The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth
  publication-title: J Bacteriol
  doi: 10.1128/JB.00963-06
  contributor:
    fullname: P Fernandez
– volume: 287
  start-page: 26749
  issue: 32
  year: 2012
  ident: ppat.1010729.ref043
  article-title: Unveiling the novel dual specificity protein kinases in Bacillus anthracis: identification of the first prokaryotic dual specificity tyrosine phosphorylation-regulated kinase (DYRK)-like kinase
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M112.351304
  contributor:
    fullname: G Arora
– volume: 45
  start-page: 761
  issue: 3
  year: 1984
  ident: ppat.1010729.ref021
  article-title: Immunoelectrophoretic analysis, toxicity, and kinetics of in vitro production of the protective antigen and lethal factor components of Bacillus anthracis toxin
  publication-title: Infect Immun
  doi: 10.1128/iai.45.3.761-767.1984
  contributor:
    fullname: JW Ezzell
– volume: 185
  start-page: 1911
  issue: 6
  year: 2003
  ident: ppat.1010729.ref078
  article-title: Additional targets of the Bacillus subtilis global regulator CodY identified by chromatin immunoprecipitation and genome-wide transcript analysis
  publication-title: J Bacteriol
  doi: 10.1128/JB.185.6.1911-1922.2003
  contributor:
    fullname: V Molle
– volume: 88
  issue: 9
  year: 2020
  ident: ppat.1010729.ref051
  article-title: Distinct Morphological Fates of Uropathogenic Escherichia coli Intracellular Bacterial Communities: Dependency on Urine Composition and pH
  publication-title: Infect Immun
  doi: 10.1128/IAI.00884-19
  contributor:
    fullname: G Iosifidis
– volume: 7
  start-page: 184
  year: 2016
  ident: ppat.1010729.ref034
  article-title: Role of Protein Phosphorylation in the Regulation of Cell Cycle and DNA-Related Processes in Bacteria
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2016.00184
  contributor:
    fullname: T Garcia-Garcia
– volume: 215
  start-page: 107622
  year: 2020
  ident: ppat.1010729.ref084
  article-title: Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution, structures, diseases and inhibitors
  publication-title: Pharmacol Ther
  doi: 10.1016/j.pharmthera.2020.107622
  contributor:
    fullname: R Kamada
– volume: 26
  start-page: 2175
  issue: 10
  year: 2014
  ident: ppat.1010729.ref088
  article-title: Ser/Thr-phosphoprotein phosphatases in chondrogenesis: neglected components of a two-player game
  publication-title: Cell Signal
  doi: 10.1016/j.cellsig.2014.06.013
  contributor:
    fullname: C Matta
– volume: 14
  start-page: 2233
  issue: 8
  year: 2012
  ident: ppat.1010729.ref101
  article-title: CodY, a pleiotropic regulator, influences multicellular behaviour and efficient production of virulence factors in Bacillus cereus
  publication-title: Environ Microbiol
  doi: 10.1111/j.1462-2920.2012.02766.x
  contributor:
    fullname: T Lindback
– volume: 280
  start-page: 324
  issue: 2
  year: 2013
  ident: ppat.1010729.ref086
  article-title: Protein Ser/Thr phosphatases—the ugly ducklings of cell signalling
  publication-title: FEBS J
  doi: 10.1111/j.1742-4658.2012.08609.x
  contributor:
    fullname: DL Brautigan
– volume: 3
  issue: 22
  year: 2013
  ident: ppat.1010729.ref105
  article-title: Separation and Detection of Phosphorylated and Nonphosphorylated BvgA, a Bordetella pertussis Response Regulator, in vivo and in vitro
  publication-title: Bio Protoc
  doi: 10.21769/BioProtoc.970
  contributor:
    fullname: Q Chen
– volume: 58
  start-page: 520
  issue: 4
  year: 2018
  ident: ppat.1010729.ref040
  article-title: GroEL Mediates Folding of Bacillus anthracis Serine/Threonine Protein Kinase, PrkC
  publication-title: Indian J Microbiol
  doi: 10.1007/s12088-018-0744-y
  contributor:
    fullname: R Virmani
– volume: 292
  start-page: 2714
  issue: 7
  year: 2017
  ident: ppat.1010729.ref076
  article-title: Structure of the Branched-chain Amino Acid and GTP-sensing Global Regulator, CodY, from Bacillus subtilis
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M116.754309
  contributor:
    fullname: VM Levdikov
– volume: 6
  start-page: 697
  issue: 4
  year: 2007
  ident: ppat.1010729.ref074
  article-title: The serine/threonine/tyrosine phosphoproteome of the model bacterium Bacillus subtilis
  publication-title: Mol Cell Proteomics
  doi: 10.1074/mcp.M600464-MCP200
  contributor:
    fullname: B Macek
– volume: 9
  start-page: 482
  year: 2018
  ident: ppat.1010729.ref027
  article-title: A Dual Role for the Bacillus anthracis Master Virulence Regulator AtxA: Control of Sporulation and Anthrax Toxin Production
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2018.00482
  contributor:
    fullname: JL Dale
– volume: 10
  start-page: 17910
  issue: 1
  year: 2020
  ident: ppat.1010729.ref055
  article-title: Cell morphology maintenance in Bacillus subtilis through balanced peptidoglycan synthesis and hydrolysis
  publication-title: Sci Rep
  doi: 10.1038/s41598-020-74609-5
  contributor:
    fullname: J Sassine
– volume: 291
  start-page: 24215
  issue: 46
  year: 2016
  ident: ppat.1010729.ref092
  article-title: Serine/Threonine Protein Phosphatase PstP of Mycobacterium tuberculosis Is Necessary for Accurate Cell Division and Survival of Pathogen
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M116.754531
  contributor:
    fullname: AK Sharma
– volume: 161
  start-page: 81
  issue: 2
  year: 2008
  ident: ppat.1010729.ref087
  article-title: Protein Ser/Thr phosphatases of parasitic protozoa
  publication-title: Mol Biochem Parasitol
  doi: 10.1016/j.molbiopara.2008.06.008
  contributor:
    fullname: MA Kutuzov
– volume: 17
  start-page: 855
  issue: 3
  year: 2015
  ident: ppat.1010729.ref106
  article-title: clpC operon regulates cell architecture and sporulation in Bacillus anthracis
  publication-title: Environ Microbiol
  doi: 10.1111/1462-2920.12548
  contributor:
    fullname: LK Singh
– volume: 196
  start-page: 2646
  issue: 14
  year: 2014
  ident: ppat.1010729.ref104
  article-title: HupB, a nucleoid-associated protein of Mycobacterium tuberculosis, is modified by serine/threonine protein kinases in vivo
  publication-title: J Bacteriol
  doi: 10.1128/JB.01625-14
  contributor:
    fullname: M Gupta
– volume: 5
  start-page: 395
  issue: 3
  year: 2020
  ident: ppat.1010729.ref095
  article-title: Transcriptional regulation by sigma factor phosphorylation in bacteria
  publication-title: Nat Microbiol
  doi: 10.1038/s41564-019-0648-6
  contributor:
    fullname: SC Iyer
– volume: 286
  start-page: 44197
  issue: 51
  year: 2011
  ident: ppat.1010729.ref081
  article-title: Serine/threonine phosphatase Stp1 mediates post-transcriptional regulation of hemolysin, autolysis, and virulence of group B Streptococcus
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M111.313486
  contributor:
    fullname: K Burnside
– volume: 75
  issue: 4
  year: 2017
  ident: ppat.1010729.ref098
  article-title: Biochemical characterization of the GTP-sensing protein, CodY of Bacillus anthracis
  publication-title: Pathog Dis
  doi: 10.1093/femspd/ftx048
  contributor:
    fullname: S Joon
– volume: 17
  start-page: 645
  year: 2016
  ident: ppat.1010729.ref071
  article-title: Changes in Bacillus anthracis CodY regulation under host-specific environmental factor deprived conditions
  publication-title: BMC Genomics
  doi: 10.1186/s12864-016-3004-8
  contributor:
    fullname: SK Kim
– volume: 201
  issue: 23
  year: 2019
  ident: ppat.1010729.ref024
  article-title: Bacillus anthracis Virulence Regulator AtxA Binds Specifically to the pagA Promoter Region
  publication-title: J Bacteriol
  doi: 10.1128/JB.00569-19
  contributor:
    fullname: RM McCall
– volume: 64
  start-page: 503
  issue: 3
  year: 2000
  ident: ppat.1010729.ref065
  article-title: Programmed death in bacteria
  publication-title: Microbiol Mol Biol Rev
  doi: 10.1128/MMBR.64.3.503-514.2000
  contributor:
    fullname: K. Lewis
– volume: 6
  start-page: 211
  issue: 4
  year: 1995
  ident: ppat.1010729.ref091
  article-title: Flicking the switches: phosphorylation of serine/threonine protein phosphatases
  publication-title: Semin Cancer Biol
  doi: 10.1006/scbi.1995.0028
  contributor:
    fullname: DL Brautigan
– volume: 54
  start-page: 306
  issue: 4
  year: 2012
  ident: ppat.1010729.ref067
  article-title: Comparative analysis of virulence factors secreted by Bacillus anthracis Sterne at host body temperature
  publication-title: Lett Appl Microbiol
  doi: 10.1111/j.1472-765X.2012.03209.x
  contributor:
    fullname: SK Kim
– volume: 72
  start-page: 937
  issue: 1
  year: 2006
  ident: ppat.1010729.ref109
  article-title: Autoinducer 2 affects biofilm formation by Bacillus cereus
  publication-title: Appl Environ Microbiol
  doi: 10.1128/AEM.72.1.937-941.2006
  contributor:
    fullname: S Auger
– volume: 88
  start-page: 921
  issue: 5
  year: 2013
  ident: ppat.1010729.ref062
  article-title: Bacillus subtilis serine/threonine protein kinase YabT is involved in spore development via phosphorylation of a bacterial recombinase
  publication-title: Mol Microbiol
  doi: 10.1111/mmi.12233
  contributor:
    fullname: V Bidnenko
– volume: 195
  start-page: 1204
  issue: 6
  year: 2013
  ident: ppat.1010729.ref029
  article-title: Identification of CodY targets in Bacillus anthracis by genome-wide in vitro binding analysis
  publication-title: J Bacteriol
  doi: 10.1128/JB.02041-12
  contributor:
    fullname: A Chateau
– year: 2021
  ident: ppat.1010729.ref041
  article-title: Bacillus anthracis chain length, a virulence determinant, is regulated by membrane localized serine/threonine protein kinase PrkC
  publication-title: J Bacteriol
  contributor:
    fullname: N Dhasmana
– volume: 176
  start-page: 5188
  issue: 16
  year: 1994
  ident: ppat.1010729.ref019
  article-title: The three Bacillus anthracis toxin genes are coordinately regulated by bicarbonate and temperature
  publication-title: J Bacteriol
  doi: 10.1128/jb.176.16.5188-5192.1994
  contributor:
    fullname: JC Sirard
– volume: 151
  start-page: 1751
  issue: Pt 6
  year: 2005
  ident: ppat.1010729.ref028
  article-title: The DNA-binding specificity of the Bacillus anthracis AbrB protein
  publication-title: Microbiology (Reading)
  doi: 10.1099/mic.0.27803-0
  contributor:
    fullname: MA Strauch
– volume: 25
  start-page: 4445
  issue: 12
  year: 2011
  ident: ppat.1010729.ref073
  article-title: CodY regulation is required for full virulence and heme iron acquisition in Bacillus anthracis
  publication-title: FASEB J
  doi: 10.1096/fj.11-188912
  contributor:
    fullname: A Chateau
– volume: 73
  start-page: 1481
  issue: 5
  year: 2007
  ident: ppat.1010729.ref108
  article-title: Air-liquid interface biofilms of Bacillus cereus: formation, sporulation, and dispersion
  publication-title: Appl Environ Microbiol
  doi: 10.1128/AEM.01781-06
  contributor:
    fullname: JG Wijman
– volume: 189
  start-page: 1313
  issue: 7
  year: 2004
  ident: ppat.1010729.ref004
  article-title: Time-lapse confocal imaging of development of Bacillus anthracis in macrophages
  publication-title: J Infect Dis
  doi: 10.1086/382656
  contributor:
    fullname: G Ruthel
– volume: 7
  start-page: 568
  year: 2016
  ident: ppat.1010729.ref059
  article-title: Impact of Serine/Threonine Protein Kinases on the Regulation of Sporulation in Bacillus subtilis
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2016.00568
  contributor:
    fullname: F Pompeo
– volume: 98
  start-page: 109
  year: 1932
  ident: ppat.1010729.ref036
  article-title: Serinephosphoric acid obtained on hydrolysis of vitellinic acid
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(18)76142-5
  contributor:
    fullname: FA Lipmann
– volume: 24
  start-page: 47
  year: 2015
  ident: ppat.1010729.ref083
  article-title: Ser/Thr phosphorylation as a regulatory mechanism in bacteria
  publication-title: Curr Opin Microbiol
  doi: 10.1016/j.mib.2015.01.005
  contributor:
    fullname: J. Dworkin
– volume: 21
  start-page: 359
  issue: 2
  year: 2002
  ident: ppat.1010729.ref002
  article-title: Anthrax and wildlife
  publication-title: Rev Sci Tech
  doi: 10.20506/rst.21.2.1336
  contributor:
    fullname: ME Hugh-Jones
– volume: 6
  start-page: 217
  issue: 5
  year: 2019
  ident: ppat.1010729.ref085
  article-title: Ser/Thr protein phosphatases in fungi: structure, regulation and function
  publication-title: Microb Cell
  doi: 10.15698/mic2019.05.677
  contributor:
    fullname: J Arino
– volume: 76
  start-page: 1527
  issue: 6
  year: 2010
  ident: ppat.1010729.ref046
  article-title: ExsB, an unusually highly phosphorylated protein required for the stable attachment of the exosporium of Bacillus anthracis
  publication-title: Mol Microbiol
  doi: 10.1111/j.1365-2958.2010.07182.x
  contributor:
    fullname: SA McPherson
– volume: 161
  start-page: 1720
  issue: 9
  year: 2015
  ident: ppat.1010729.ref094
  article-title: Serine/threonine/tyrosine phosphorylation regulates DNA binding of bacterial transcriptional regulators
  publication-title: Microbiology (Reading)
  doi: 10.1099/mic.0.000148
  contributor:
    fullname: A Kalantari
– volume: 17
  start-page: 651
  issue: 11
  year: 2019
  ident: ppat.1010729.ref080
  article-title: Protein post-translational modifications in bacteria
  publication-title: Nat Rev Microbiol
  doi: 10.1038/s41579-019-0243-0
  contributor:
    fullname: B Macek
– volume: 184
  start-page: 6109
  issue: 22
  year: 2002
  ident: ppat.1010729.ref093
  article-title: The PrpC serine-threonine phosphatase and PrkC kinase have opposing physiological roles in stationary-phase Bacillus subtilis cells
  publication-title: J Bacteriol
  doi: 10.1128/JB.184.22.6109-6114.2002
  contributor:
    fullname: TA Gaidenko
– volume: 214
  start-page: 281
  issue: 2
  year: 2016
  ident: ppat.1010729.ref011
  article-title: Physical Sequestration of Bacillus anthracis in the Pulmonary Capillaries in Terminal Infection
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jiw098
  contributor:
    fullname: G Jouvion
– volume: 75
  start-page: 1064
  issue: 5
  year: 2010
  ident: ppat.1010729.ref049
  article-title: Division and cell envelope regulation by Ser/Thr phosphorylation: Mycobacterium shows the way
  publication-title: Mol Microbiol
  doi: 10.1111/j.1365-2958.2009.07041.x
  contributor:
    fullname: V Molle
– volume: 54
  start-page: 11
  year: 2020
  ident: ppat.1010729.ref052
  article-title: Cell morphology as a virulence determinant: lessons from Helicobacter pylori
  publication-title: Curr Opin Microbiol
  doi: 10.1016/j.mib.2019.12.002
  contributor:
    fullname: NR Salama
– volume: 4
  start-page: 1337
  issue: 8
  year: 2019
  ident: ppat.1010729.ref001
  article-title: The global distribution of Bacillus anthracis and associated anthrax risk to humans, livestock and wildlife
  publication-title: Nat Microbiol
  doi: 10.1038/s41564-019-0435-4
  contributor:
    fullname: CJ Carlson
– volume: 161
  start-page: 735
  issue: 9
  year: 2010
  ident: ppat.1010729.ref022
  article-title: AtxA, a Bacillus anthracis global virulence regulator
  publication-title: Res Microbiol
  doi: 10.1016/j.resmic.2010.09.006
  contributor:
    fullname: A. Fouet
– volume: 13
  start-page: 76
  year: 2015
  ident: ppat.1010729.ref060
  article-title: Phosphoproteome dynamics mediate revival of bacterial spores
  publication-title: BMC Biol
  doi: 10.1186/s12915-015-0184-7
  contributor:
    fullname: A Rosenberg
– volume: 55
  start-page: 647
  year: 2001
  ident: ppat.1010729.ref008
  article-title: Anthrax
  publication-title: Annu Rev Microbiol
  doi: 10.1146/annurev.micro.55.1.647
  contributor:
    fullname: M Mock
– volume: 5
  start-page: 206
  issue: 4
  year: 2003
  ident: ppat.1010729.ref096
  article-title: Transcription regulators potentially controlled by HPr kinase/phosphorylase in Gram-negative bacteria
  publication-title: J Mol Microbiol Biotechnol
  contributor:
    fullname: G Boel
– volume: 3
  start-page: 601
  issue: 8
  year: 2005
  ident: ppat.1010729.ref056
  article-title: Bacterial cell shape
  publication-title: Nat Rev Microbiol
  doi: 10.1038/nrmicro1205
  contributor:
    fullname: MT Cabeen
– volume: 80
  start-page: 187
  issue: 1
  year: 2016
  ident: ppat.1010729.ref054
  article-title: Staying in Shape: the Impact of Cell Shape on Bacterial Survival in Diverse Environments
  publication-title: Microbiol Mol Biol Rev
  doi: 10.1128/MMBR.00031-15
  contributor:
    fullname: DC Yang
– volume: 469
  start-page: 672
  issue: 3
  year: 2016
  ident: ppat.1010729.ref072
  article-title: Overexpression of the pleiotropic regulator CodY decreases sporulation, attachment and pellicle formation in Bacillus anthracis
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2015.12.019
  contributor:
    fullname: M Gopalani
– volume: 9
  start-page: 486
  year: 2018
  ident: ppat.1010729.ref063
  article-title: Phosphorylation of the Bacillus subtilis Replication Controller YabA Plays a Role in Regulation of Sporulation and Biofilm Formation
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2018.00486
  contributor:
    fullname: T Garcia Garcia
– volume: 132
  start-page: 557
  issue: 2
  year: 1986
  ident: ppat.1010729.ref015
  article-title: Virulence and immunogenicity in experimental animals of Bacillus anthracis strains harbouring or lacking 110 MDa and 60 MDa plasmids
  publication-title: J Gen Microbiol
  contributor:
    fullname: I Uchida
– volume: 4
  issue: 4
  year: 2016
  ident: ppat.1010729.ref009
  article-title: Surviving Between Hosts: Sporulation and Transmission
  publication-title: Microbiol Spectr
  doi: 10.1128/microbiolspec.VMBF-0029-2015
  contributor:
    fullname: MC Swick
– volume: 62
  start-page: 123
  issue: 2
  year: 2011
  ident: ppat.1010729.ref102
  article-title: The CodY pleiotropic repressor controls virulence in gram-positive pathogens
  publication-title: FEMS Immunol Med Microbiol
  doi: 10.1111/j.1574-695X.2011.00812.x
  contributor:
    fullname: L Stenz
– volume: 3
  start-page: 20
  issue: 1
  year: 2015
  ident: ppat.1010729.ref057
  article-title: Anthrax: A disease of biowarfare and public health importance
  publication-title: World J Clin Cases
  doi: 10.12998/wjcc.v3.i1.20
  contributor:
    fullname: AK Goel
– volume: 123
  start-page: 264
  issue: 5–6
  year: 2010
  ident: ppat.1010729.ref058
  article-title: World Health Organization (WHO): Anthrax in Humans and Animals
  publication-title: Berl Munch Tierarztl
  contributor:
    fullname: Walther
– volume: 175
  start-page: 5329
  issue: 17
  year: 1993
  ident: ppat.1010729.ref025
  article-title: Cloning and characterization of a gene whose product is a trans-activator of anthrax toxin synthesis
  publication-title: J Bacteriol
  doi: 10.1128/jb.175.17.5329-5338.1993
  contributor:
    fullname: I Uchida
– volume: 1804
  start-page: 620
  issue: 3
  year: 2010
  ident: ppat.1010729.ref082
  article-title: Protein kinase and phosphatase signaling in Mycobacterium tuberculosis physiology and pathogenesis
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbapap.2009.09.008
  contributor:
    fullname: J Chao
– volume: 12
  issue: 7
  year: 2020
  ident: ppat.1010729.ref018
  article-title: Anthrax Edema and Lethal Toxins Differentially Target Human Lung and Blood Phagocytes
  publication-title: Toxins (Basel)
  doi: 10.3390/toxins12070464
  contributor:
    fullname: VI Patel
– volume: 9
  start-page: e84947
  issue: 1
  year: 2014
  ident: ppat.1010729.ref012
  article-title: Toxin-independent virulence of Bacillus anthracis in rabbits
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0084947
  contributor:
    fullname: H Levy
– volume: 53
  start-page: 599
  issue: 2
  year: 2004
  ident: ppat.1010729.ref079
  article-title: Activation of the Bacillus subtilis global regulator CodY by direct interaction with branched-chain amino acids
  publication-title: Mol Microbiol
  doi: 10.1111/j.1365-2958.2004.04135.x
  contributor:
    fullname: RP Shivers
– volume: 3
  start-page: 7
  year: 2017
  ident: ppat.1010729.ref038
  article-title: Ser/Thr protein kinase PrkC-mediated regulation of GroEL is critical for biofilm formation in Bacillus anthracis
  publication-title: NPJ Biofilms Microbiomes
  doi: 10.1038/s41522-017-0015-4
  contributor:
    fullname: G Arora
– volume: 73
  start-page: 714
  issue: 5
  year: 2016
  ident: ppat.1010729.ref070
  article-title: Late-Exponential Gene Expression in codY-Deficient Bacillus anthracis in a Host-Like Environment
  publication-title: Curr Microbiol
  doi: 10.1007/s00284-016-1120-y
  contributor:
    fullname: SK Kim
– volume: 192
  start-page: 400
  issue: 2
  year: 2010
  ident: ppat.1010729.ref045
  article-title: Regulatory interactions of a virulence-associated serine/threonine phosphatase-kinase pair in Bacillus anthracis
  publication-title: J Bacteriol
  doi: 10.1128/JB.01221-09
  contributor:
    fullname: SM Shakir
– volume: 191
  start-page: 5134
  issue: 16
  year: 2009
  ident: ppat.1010729.ref047
  article-title: A new minimal replicon of Bacillus anthracis plasmid pXO1
  publication-title: J Bacteriol
  doi: 10.1128/JB.00422-09
  contributor:
    fullname: AP Pomerantsev
– volume: 288
  start-page: 756
  issue: 3
  year: 2021
  ident: ppat.1010729.ref089
  article-title: Plant protein phosphatases: What do we know about their mechanism of action?
  publication-title: FEBS J
  doi: 10.1111/febs.15454
  contributor:
    fullname: M Bheri
– volume: 170
  start-page: 804
  issue: 4332
  year: 1952
  ident: ppat.1010729.ref037
  article-title: Isolation of phosphothreonine from bovine casein
  publication-title: Nature
  doi: 10.1038/170804b0
  contributor:
    fullname: CH De Verdier
– volume: 39
  start-page: 371
  issue: 1
  year: 1983
  ident: ppat.1010729.ref014
  article-title: Evidence for plasmid-mediated toxin production in Bacillus anthracis
  publication-title: Infect Immun
  doi: 10.1128/iai.39.1.371-376.1983
  contributor:
    fullname: P Mikesell
– volume: 12
  start-page: e0184975
  issue: 10
  year: 2017
  ident: ppat.1010729.ref100
  article-title: The CodY-dependent clhAB2 operon is involved in cell shape, chaining and autolysis in Bacillus cereus ATCC 14579
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0184975
  contributor:
    fullname: E Huillet
– volume: 9
  start-page: 198
  issue: 3–4
  year: 2005
  ident: ppat.1010729.ref033
  article-title: Role of protein phosphorylation on serine/threonine and tyrosine in the virulence of bacterial pathogens
  publication-title: J Mol Microbiol Biotechnol
  contributor:
    fullname: AJ Cozzone
– volume: 193
  start-page: 1833
  issue: 8
  year: 2011
  ident: ppat.1010729.ref044
  article-title: Autoregulatory characteristics of a Bacillus anthracis serine/threonine kinase
  publication-title: J Bacteriol
  doi: 10.1128/JB.01401-10
  contributor:
    fullname: KM Bryant-Hudson
– volume: 26
  start-page: 715
  issue: 5
  year: 2013
  ident: ppat.1010729.ref042
  article-title: Zinc regulates the activity of kinase-phosphatase pair (BasPrkC/BasPrpC) in Bacillus anthracis
  publication-title: Biometals
  doi: 10.1007/s10534-013-9646-y
  contributor:
    fullname: G Arora
– volume: 19
  start-page: 45
  year: 2003
  ident: ppat.1010729.ref017
  article-title: Anthrax toxin
  publication-title: Annu Rev Cell Dev Biol
  doi: 10.1146/annurev.cellbio.19.111301.140655
  contributor:
    fullname: RJ Collier
– volume: 289
  start-page: 9460
  issue: 14
  year: 2014
  ident: ppat.1010729.ref031
  article-title: In the beginning, there was protein phosphorylation
  publication-title: J Biol Chem
  doi: 10.1074/jbc.R114.557926
  contributor:
    fullname: JM Kyriakis
– volume: 6
  start-page: 382
  year: 2015
  ident: ppat.1010729.ref061
  article-title: Eukaryote-like Ser/Thr protein kinase PrkA modulates sporulation via regulating the transcriptional factor sigma(K) in Bacillus subtilis
  publication-title: Front Microbiol
  contributor:
    fullname: J Yan
– volume: 264
  start-page: 19103
  issue: 32
  year: 1989
  ident: ppat.1010729.ref103
  article-title: A deleted variant of Bacillus anthracis protective antigen is non-toxic and blocks anthrax toxin action in vivo
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(19)47273-6
  contributor:
    fullname: Y Singh
– volume: 8
  start-page: e1003027
  issue: 12
  year: 2012
  ident: ppat.1010729.ref053
  article-title: Morphogenesis in fungal pathogenicity: shape, size, and surface
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1003027
  contributor:
    fullname: L Wang
– volume: 70
  start-page: 103
  year: 2016
  ident: ppat.1010729.ref097
  article-title: Feedback Control of Two-Component Regulatory Systems
  publication-title: Annu Rev Microbiol
  doi: 10.1146/annurev-micro-102215-095331
  contributor:
    fullname: EA Groisman
– volume: 187
  start-page: 4127
  issue: 12
  year: 2005
  ident: ppat.1010729.ref075
  article-title: A region of Bacillus subtilis CodY protein required for interaction with DNA
  publication-title: J Bacteriol
  doi: 10.1128/JB.187.12.4127-4139.2005
  contributor:
    fullname: P Joseph
– volume: 6
  start-page: 18908
  year: 2016
  ident: ppat.1010729.ref069
  article-title: Next-Generation Bacillus anthracis Live Attenuated Spore Vaccine Based on the htrA(-) (High Temperature Requirement A) Sterne Strain
  publication-title: Sci Rep
  doi: 10.1038/srep18908
  contributor:
    fullname: T Chitlaru
– volume: 30
  start-page: 481
  issue: 6
  year: 2009
  ident: ppat.1010729.ref003
  article-title: Anthrax in animals
  publication-title: Mol Aspects Med
  doi: 10.1016/j.mam.2009.08.004
  contributor:
    fullname: W Beyer
– volume: 169
  start-page: 931
  issue: 12
  year: 2014
  ident: ppat.1010729.ref066
  article-title: Life cycle and spore resistance of spore-forming Bacillus atrophaeus
  publication-title: Microbiol Res
  doi: 10.1016/j.micres.2014.05.001
  contributor:
    fullname: SR Sella
– volume: 16
  start-page: 1171
  issue: 6
  year: 1995
  ident: ppat.1010729.ref026
  article-title: The atxA gene product activates transcription of the anthrax toxin genes and is essential for virulence
  publication-title: Mol Microbiol
  doi: 10.1111/j.1365-2958.1995.tb02340.x
  contributor:
    fullname: Z Dai
– volume: 203
  start-page: 1111
  issue: 4385
  year: 1979
  ident: ppat.1010729.ref035
  article-title: Phosphorylation of Isocitrate dehydrogenase of Escherichia coli
  publication-title: Science
  doi: 10.1126/science.34215
  contributor:
    fullname: M Garnak
– volume: 13
  start-page: 756
  issue: 8
  year: 2012
  ident: ppat.1010729.ref048
  article-title: Bacterial cell division regulation by Ser/Thr kinases: a structural perspective
  publication-title: Curr Protein Pept Sci
  doi: 10.2174/138920312804871201
  contributor:
    fullname: A Ruggiero
– volume: 181
  start-page: 6509
  issue: 20
  year: 1999
  ident: ppat.1010729.ref016
  article-title: Sequence and organization of pXO1, the large Bacillus anthracis plasmid harboring the anthrax toxin genes
  publication-title: J Bacteriol
  doi: 10.1128/JB.181.20.6509-6515.1999
  contributor:
    fullname: RT Okinaka
SSID ssj0041316
Score 2.4435055
Snippet Reversible protein phosphorylation at serine/threonine residues is one of the most common protein modifications, widely observed in all kingdoms of life. The...
SourceID plos
doaj
pubmedcentral
proquest
gale
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
StartPage e1010729
SubjectTerms Anthrax
Bacillus anthracis
Bacterial proteins
Binding sites
Biology and Life Sciences
Catalysts
Cell death
Chemical properties
Edema
Enzyme kinetics
Gene sequencing
Genes
Genomes
Glycerol
Growth
Kinases
Life cycles
Medicine and Health Sciences
Mutants
Pathogens
Phosphatase
Phosphatases
Phosphorylation
Physiological aspects
Physiology
Plasmids
Prokaryotes
Protein kinases
Protein phosphatase
Protein-serine/threonine kinase
Proteins
Regulation
Serine
Sporulation
Streptococcus infections
Structure-function relationships
Synthesis
Threonine
Toxins
Virulence
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3da9RAEF_kQPBF1Co9W2Urgk_r7eVrs4-tWFrBQ6qF-rTsp3cQktDkHvrfO7ubO7ug9MXHy0zCZWZn9pdk5jcIvXcMQCp1nEjKM1IAgifSMk2Ys0VZG2NU7huFv66qi-viy015c2_Ul68Ji_TA0XAL7kwpYZuRPAMwr4wsnFkuFQBDphizKmRfyncPUzEHQ2YOQ0_9UBzC8qqamuZytlxMPvrY9zLQR9MIL_9sSoG7f5-hZ33TDQn8TIsn7-1G58_Q0wlG4tP495-jR7Z9gR7HwZJ3B-jnVddY3Dk8hO6-xQge8-9dLQ68DJsW9-tu6NdyhE0Mf7vtVxiOARbEzcZZrO90PP1M6k3TbAcs_TwF-DG8RNfnn398uiDTEAWiIbRGoiEkc76UzJpKuUrXqnQmM5Y7pRRgHy6VqlltDdWKG5XpOpM2BxxGa3AXKLxCs7Zr7SHCgAyM0wDwFHeFYU5x8HLBeGUKqiHzzRHZWVH0kStDhA9mDJ4xol2Et7qYrD5HZ97Ue13PdB0OgP_F5H_xkP_n6J13lPBcFq0vlvklt8MgLr-vxCkDrJbDUqT_VLpKlD5MSq4Dz2o5NSjAzXuOrETzONGEiNSJ-NAvmt09DyIDke8o5DWcuVtIfxef7MX-or4ArrXdFnQqziCaKGNzxJIFmJgvlbSbdSAM95yHWVW-_h_2PkJPMt8BEmogj9FsvN3aN4DLRvU2hOBvOgk2mA
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1bi9QwFA46IvgiXtlZV4ki-BSnTS9pnmRXXFbBQVYXxqeQ685Aaeu087D_3pM0M2tBfZzmtEPPLd9JzwWht44BSE0cJzLhlOSA4Im0TBPmbF5UxhiV-ULhr8vy4ir_sipW8cCtj2mVe58YHLVptT8jX1AGe1MOwUL1oftF_NQo_3U1jtC4i-6lFJQX9JmtDgEX-Ocw-tSPxiEsK8tYOpexdBEl9b7rZGginYwg83ZrCh38D3561tVtPwGh0xTKP_ak80foYQST-HSU_mN0xzZP0P1xvOTNU_Tzsq0tbh3uQ43fYgC5-dNXi0N3hk2Du3Xbd2s5wFaGv227JYZrgAhxvXEW6xs93n4m9aaudz2WfqoC_OifoavzTz8-XpA4SoFoMLCBaDDMjKeSWVMqV-pKFc5QY7lTSgEC4lKpilXWJFpxo6iuqLQZoLGkAqEBwXM0a9rGHiEM-MA4DTBPcZcb5hQHWeeMlyZPNPi_OSJ7Lopu7JghwmczBpHGyBfhuS4i1-fozLP6QOv7XYcL7fZaRPMR3JlCAtiQnEJIp4zMnUlTBeEBU4xZNUdvvKCE72jR-JSZa7nre_H5-1KcguIABgNf9U-iywnRu0jkWpCslrFMAV7ed8qaUJ5MKMEu9WT5yCvN_p17cavBcOdekf6-_Pqw7B_q0-Aa2-6ApuQMbCphbI7YRAEn7JuuNJt1aBvuOx_Ssjj-_5-_QA-or_AIOY4naDZsd_Yl4K5BvQrG9Ru-ty2V
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Open Access Journals
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1ba9RAFB7qiuCL1BtdrTKK4FNqNrfJPIi0YqmCi1QX6tMw1-5CSOImC91_7zmzyeJA--ZjMmcCOZeZb5JzvkPIO8cApMaORzLmSZQBgo-kZTpizmZ5aYxRKRYKf58XF4vs21V-dUDGnq2DArtbj3bYT2qxrk5u_mw_QcB_9F0b2GycdNK20hNCIxn2PXI_QWouTObL9v8VYMX2zVCxWU7E0qIYiunuekqwWXlO__3KPWmrpgtgaZhU-c8udX5IHg3wkp7u_OExObD1E_Jg13By-5T8vmwqSxtHO1_196EHS-L3WEs9X8Oqpu2y6dql7GFzoz_W7ZzCPcCItFo5S_VW76afSb2qqk1HJfZZgIvuGVmcf_n1-SIamitEGkKujzSEaspnkllTKFfoUuXOJMZyp5QCTMSlUiUrrYm14kYlukykTQGfxSWYEQSek0nd1PaIUEAMxmkAfoq7zDCnOFg_Y7wwWaxhRZySaNSiaHccGsL_SGNw9tjpRaDWxaD1KTlDVe9lkQHb32jW12IIKMGdySXAD8kTOOQpIzNnZjMFBwamGLNqSt6ioQRyXNSYRHMtN10nvv6ci1MGGC4FF43vFLoMhN4PQq4By2o5FC7AyyN3ViB5HEhCpOpg-AidZnznTiQwhJWGvISZoyPdPvxmP4wPxcS42jYbkCk4gyiLGZsSFjhgoL5wpF4tPZE4ciEmRf7if-j7JXmYYGWIz408JpN-vbGvAK_16rUPwb9wX0Ct
  priority: 102
  providerName: Scholars Portal
Title Role of serine/threonine protein phosphatase PrpN in the life cycle of Bacillus anthracis
URI https://www.proquest.com/docview/2715142498
https://search.proquest.com/docview/2697092077
https://pubmed.ncbi.nlm.nih.gov/PMC9371265
https://doaj.org/article/9fd5a241a92149bda4fd11b8827b77eb
http://dx.doi.org/10.1371/journal.ppat.1010729
Volume 18
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9tAEF4Sl5ZcSp_EaWq2pdCTbFmv1R7jkJAWbIzbgHsS-4wFiiQs-ZB_39mVZLrQXnoxWDNrpJ2Z3W_lmW8Q-qIJgFRfU4_5NPAiQPAeU0R4RKsoTqWUPDSFwstVcncffd_G2xMUD7UwNmlf8HxaFo_TMt_Z3Mr6UcyGPLHZenltONyCJJ6dolNw0OGI3i2_sCjbfqemH45HwiTp6-VgyKw3z7SumWWONqzZZ-hFGBtuTBo6W5Nl8D-u06O6qBoHhLoplH_sSbev0MseTOKr7qZfoxNVvkHPu_aST2_Rr01VKFxp3Ngav1kLdjNvXxW27Ax5ietd1dQ71sJWhtf7eoXhGiBCXORaYfEkuuELJvKiODSYma4K8KV5h-5vb35e33l9KwVPQIC1noDADOmcESUTrhOR8ljLQCqqOeeAgCjjPCWpkr7gVPJApAFTIaAxPwWjgcJ7NCqrUp0jDPhAagEwj1MdSaI5BVtHhCYy8gWsf2PkDbOY1R1jRmb_NiNw0ujmJTMGyHoDjNHCTPVR1_Bd2wvV_iHrrZ5RLWMGYIPRAI50XLJIy_mcw_GAcEIUH6PPxlCZYbQoTcrMAzs0Tfbtxyq7IoDYQnBI_59KG0fpa6-kK7CsYH2ZAjy8YcpyNC8dTYhL4YjPjdMMz9xkAYhMXSFNYeTgSH8XfzqKzY-aNLhSVQfQSSiBmPIJGSPiOKAzfa4EosjShvdRc_HfIz-gs8AUf9j0x0s0avcH9REgWcsnEIhbMkHPFjer9WZiX2zA5zJKJzY4fwNG0Drr
link.rule.ids 230,315,730,783,787,867,888,2109,2228,12070,21402,24332,27938,27939,31733,31734,33758,33759,43324,43819,53806,53808,74081,74638
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1bb9MwFLagCLGXiatWNsAgJJ5C0ySN4ye0IaYOtgqNTSpPlq9rpSoJTfqwf885jtsRCXhsfJIq5-bPjs93CHnvGIDU2PFIxjyJMkDwkbRMR8zZbFIYY1SKhcIXs3x6nX2dT-Zhw60Jxyq3OdEnalNp3CMfJQzmpgwWC8Wn-leEXaPw62pooXGfPEAeLuTOZ_Pdggvys299iq1xIpbmeSidS9l4FCz1sa6lJ5GOO5B5NzV5Bv9dnh7Uq6rpgdD-Eco_5qTTx2Q_gEl63Fn_Cblny6fkYdde8vYZ-XlZrSytHG18jd-oBbvh7qulnp1hWdJ6UTX1QrYwldHv63pG4RogQrpaOkv1re5uP5F6uVptGiqxqwL8aJ6T69MvV5-nUWilEGkIsDbSEJgpH0tmTa5crgs1cSYxljulFCAgLpUqWGFNrBU3KtFFIm0KaCwuwGgg8IIMyqq0B4QCPjBOA8xT3GWGOcXB1hnjucliDflvSKKtFkXdMWYI_9mMwUqj04tArYug9SE5QVXvZJHv2l-o1jcihI_gzkwkgA3JE1jSKSMzZ8ZjBcsDphizakjeoaEEMlqUeGTmRm6aRpz9mIljcBzAYJCr_il02RP6EIRcBZbVMpQpwMsjU1ZP8qgnCXGpe8MH6DTbd27EnQfDnVtH-vvw290wPhSPwZW22oBMzhnEVMzYkLCeA_bU1x8plwtPG47Mh0k-efn_P39DHk2vLs7F-dns2yHZS7Daw593PCKDdr2xrwCDteq1D7TfGHYwhQ
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9NAEF5BEIgL4qkGCiwIiZOJ49he7wm1QNTyiKpCpXBa7bOJZNkmdg7998ysNymWgKO9Y1ue135jz4OQN44BSI0dj2TMkygFBB9Jy3TEnE2zwhijZlgo_G2Rn1ykn5fZMuQ_tSGtcucTvaM2tcZv5JOEwd6UQrBQTFxIizj7OH_f_IpwghT-aQ3jNG6SW_D0Ao2ULffBF_hqPwYVx-REbJbnoYxuxqaTILV3TSN9Q-m4B5zX25Tv5r_32aOmrNsBIB2mU_6xP83vk3sBWNKjXhMekBu2ekhu96Mmrx6Rn-d1aWntaOvr_SYdyBC_xFrqOzWsK9qs6rZZyQ62NXq2aRYUzgE6pOXaWaqvdH_5sdTrsty2VOKEBThoH5OL-acfH06iMFYh0mBsXaTBSGd8Kpk1uXK5LlTmTGIsd0opQENcKlWwwppYK25UootE2hkgs7gAAQLBEzKq6soeEApYwTgNkE9xlxrmFAe5p4znJo01-MIxiXZcFE3fPUP4X2gMoo6eLwK5LgLXx-QYWb2nxd7X_kS9uRTBlAR3JpMAPCRPILxTRqbOTKcKQgWmGLNqTF6joAR2t6hQTy7ltm3F6feFOAIlAjwGfuufROcDoreByNUgWS1DyQK8PHbNGlAeDijBRvVg-QCVZvfOrbjWZrhyp0h_X361X8abYkpcZest0OScgX3FjI0JGyjggH3DlWq98i3EsQtikmdP___wl-QO2Jj4err48ozcTbDww6c-HpJRt9na5wDHOvXC29lvc0Y0ug
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Role+of+serine%2Fthreonine+protein+phosphatase+PrpN+in+the+life+cycle+of+Bacillus+anthracis&rft.jtitle=PLoS+pathogens&rft.au=Aakriti+Gangwal&rft.au=Nitika+Sangwan&rft.au=Neha+Dhasmana&rft.au=Nishant+Kumar&rft.date=2022-08-01&rft.pub=Public+Library+of+Science+%28PLoS%29&rft.issn=1553-7366&rft.eissn=1553-7374&rft.volume=18&rft.issue=8&rft.spage=e1010729&rft_id=info:doi/10.1371%2Fjournal.ppat.1010729&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_9fd5a241a92149bda4fd11b8827b77eb
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1553-7374&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1553-7374&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1553-7374&client=summon