Chromosomal abnormalities and mental illness

• Published in: Molecular psychiatry Vol. 8; no. 3; pp. 275 - 287
• Main Authors: MacIntyre, D J, Blackwood, D H R, Porteous, D J, Pickard, B S, Muir, W J
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2003; Nature Publishing Group
• Subjects: Adult and adolescent clinical studies; Behavioral Sciences; Biological and medical sciences; Biological Psychology; Bipolar disorder; Bipolar Disorder - genetics; Breakpoints; Chromosome Aberrations; Chromosomes; Cloning; Coexistence; feature-article; Genes; Genetic analysis; Genetic Linkage; Genomes; Humans; Hypotheses; Intellectual disabilities; Intellectual Disability - genetics; Learning disabilities; Medical genetics; Medical sciences; Medicine; Medicine & Public Health; Mental disorders; Miscellaneous; Mutation; Neurosciences; Pharmacotherapy; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Schizophrenia; Schizophrenia - genetics; Sequence analysis; Susceptibility; United Kingdom > UK; Scotland; mental retardation; learning disability; bipolar disorder; schizophrenia; linkage; chromosomes; Mood disorder; Chromosomal aberration; Human; Linkage; Mental health; Schizophrenia; Chromosome; Exploration; Bipolar disorder; Developmental disorder; Mental retardation; Psychosis; Learning disability; Intellectual deficiency; Anomaly; Diagnosis

Linkage studies of mental illness have provided suggestive evidence of susceptibility loci over many broad chromosomal regions. Pinpointing causative gene mutations by conventional linkage strategies alone is problematic. The breakpoints of chromosomal abnormalities occurring in patients with mental...