Determination of Talniflumate and Niflumic Acid in Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry
A simple and rapid quantification method was developed for determining both talniflumate and niflumic acid in human plasma. After simple protein precipitation with acetonitrile, the analytes were chromatographed on a reversed-phase C18 column and detected by LC/MS/MS with electrospray ionization. Th...
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| Published in | Analytical Sciences Vol. 25; no. 4; pp. 571 - 574 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Singapore
The Japan Society for Analytical Chemistry
01.04.2009
Springer Nature Singapore Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0910-6340 1348-2246 1348-2246 |
| DOI | 10.2116/analsci.25.571 |
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| Abstract | A simple and rapid quantification method was developed for determining both talniflumate and niflumic acid in human plasma. After simple protein precipitation with acetonitrile, the analytes were chromatographed on a reversed-phase C18 column and detected by LC/MS/MS with electrospray ionization. The assay accuracy and precision were within the FDA guidance for the analytical method validation. This method was used to measure the plasma concentrations of both compounds from healthy subjects after a single oral dose of talniflumate, 740 mg. |
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| AbstractList | A simple and rapid quantification method was developed for determining both talniflumate and niflumic acid in human plasma. After simple protein precipitation with acetonitrile, the analytes were chromatographed on a reversed-phase C
18
column and detected by LC/MS/MS with electrospray ionization. The assay accuracy and precision were within the FDA guidance for the analytical method validation. This method was used to measure the plasma concentrations of both compounds from healthy subjects after a single oral dose of talniflumate, 740 mg. A simple and rapid quantification method was developed for determining both talniflumate and niflumic acid in human plasma. After simple protein precipitation with acetonitrile, the analytes were chromatographed on a reversed-phase C18 column and detected by LC/MS/MS with electrospray ionization. The assay accuracy and precision were within the FDA guidance for the analytical method validation. This method was used to measure the plasma concentrations of both compounds from healthy subjects after a single oral dose of talniflumate, 740 mg. A simple and rapid quantification method was developed for determining both talniflumate and niflumic acid in human plasma. After simple protein precipitation with acetonitrile, the analytes were chromatographed on a reversed-phase C(18) column and detected by LC/MS/MS with electrospray ionization. The assay accuracy and precision were within the FDA guidance for the analytical method validation. This method was used to measure the plasma concentrations of both compounds from healthy subjects after a single oral dose of talniflumate, 740 mg.A simple and rapid quantification method was developed for determining both talniflumate and niflumic acid in human plasma. After simple protein precipitation with acetonitrile, the analytes were chromatographed on a reversed-phase C(18) column and detected by LC/MS/MS with electrospray ionization. The assay accuracy and precision were within the FDA guidance for the analytical method validation. This method was used to measure the plasma concentrations of both compounds from healthy subjects after a single oral dose of talniflumate, 740 mg. A simple and rapid quantification method was developed for determining both talniflumate and niflumic acid in human plasma. After simple protein precipitation with acetonitrile, the analytes were chromatographed on a reversed-phase C(18) column and detected by LC/MS/MS with electrospray ionization. The assay accuracy and precision were within the FDA guidance for the analytical method validation. This method was used to measure the plasma concentrations of both compounds from healthy subjects after a single oral dose of talniflumate, 740 mg. |
| Author | KIM, Kibum KANG, Wonku |
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| Cites_doi | 10.1016/j.jpba.2007.04.028 10.1016/j.jchromb.2005.05.008 10.1016/S0378-4347(00)80107-3 10.2116/analsci.22.1597 10.1016/j.jchromb.2008.10.010 10.1016/S0021-9673(01)96107-2 10.1007/BF02976244 10.1002/bmc.412 |
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| References_xml | – reference: 2. M. Los, J. E. Boned, and C. Piccinali, Farmaco, 1981, 36, 372. – reference: 3. D.-J. Jang, J.-S. Park, H.-R. Ko, J.-P. Jee, J.-K. Kim, S.-T. Kim, and C.-K. Kim, Biomed. Chromatogr., 2005, 19, 32. – reference: 6. C. Cuechot and P. Nicolle, J. Chromatogr., A, 1984, 303, 440. – reference: 1. Martindale, The Extra Pharmacopoeia, 33rd ed., 2002, Royal Pharmaceutical Society of Great Britain, 62. – reference: 7. G. Huin, F. Bree, and J. P. Tillement, J. Chromatogr., 1981, 223, 351. – reference: 10. W. Kang, J.-H. Jeong, E. Ma, and K.-I. Kwon, J. Pharm. Biomed. Anal., 2007, 44, 1178. – reference: 9. W. Kang, Anal. Sci., 2006, 22, 1597. – reference: 4. H.-W. Lee, K.-J. Won, S.-H. Cho, Y.-H. Ha, W.-S. Park, H.-T. Yim, M. Baek, J.-H. Rew, S.-H. Yoon, S.-V. Yim, J.-H. Chung, and K.-T. Lee, J. Chromatogr., B, 2005, 821, 215. – reference: 8. E. J. Park, D. H. Na, Y.-H. Shin, and K. C. Lee, J. Chromatogr., B, 2009, 876, 159. – reference: 5. H.-J. Kim, Y.-H. Han, S.-J. Chung, M.-H. Lee, and C.-K. Shin, Arch. Pharm. Res., 1996, 19, 297. – reference: JangD-JParkJ-SKoH-RJeeJ-PKimJ-KKimS-TKimC-KBiomed. Chromatogr.2005193210.1002/bmc.4121:CAS:528:DC%2BD2MXhvFKmsr0%3D – reference: KimH-JHanY-HChungS-JLeeM-HShinC-KArch. Pharm. Res.19961929710.1007/BF029762441:CAS:528:DyaK28Xls1Wgu7k%3D – reference: KangWJeongJ-HMaEKwonK-IJ. Pharm. Biomed. Anal.200744117810.1016/j.jpba.2007.04.0281:CAS:528:DC%2BD2sXpt1Klsr0%3D – reference: KangWAnal. Sci.200622159710.2116/analsci.22.15971:CAS:528:DC%2BD2sXht1Smurw%3D – reference: Martindale, The Extra Pharmacopoeia, 33rd ed., 2002, Royal Pharmaceutical Society of Great Britain, 62. – reference: LosMBonedJ EPiccinaliCFarmaco1981363721:CAS:528:DyaL3MXks1WrtLo%3D – reference: HuinGBreeFTillementJ PJ. Chromatogr.198122335110.1016/S0378-4347(00)80107-3 – reference: LeeH-WWonK-JChoS-HHaY-HParkW-SYimH-TBaekMRewJ-HYoonS-HYimS-VChungJ-HLeeK-TJ. Chromatogr., B200582121510.1016/j.jchromb.2005.05.0081:CAS:528:DC%2BD2MXlt1GltLk%3D – reference: CuechotCNicollePJ. Chromatogr., A198430344010.1016/S0021-9673(01)96107-2 – reference: ParkE JNaD HShinY-HLeeK CJ. Chromatogr., B200987615910.1016/j.jchromb.2008.10.0101:CAS:528:DC%2BD1cXhsVCntLnF – volume: 44 start-page: 1178 year: 2007 ident: 25040020_CR10 publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/j.jpba.2007.04.028 – volume: 821 start-page: 215 year: 2005 ident: 25040020_CR4 publication-title: J. Chromatogr., B doi: 10.1016/j.jchromb.2005.05.008 – volume: 223 start-page: 351 year: 1981 ident: 25040020_CR7 publication-title: J. Chromatogr. doi: 10.1016/S0378-4347(00)80107-3 – volume: 22 start-page: 1597 year: 2006 ident: 25040020_CR9 publication-title: Anal. Sci. doi: 10.2116/analsci.22.1597 – volume: 876 start-page: 159 year: 2009 ident: 25040020_CR8 publication-title: J. Chromatogr., B doi: 10.1016/j.jchromb.2008.10.010 – volume: 303 start-page: 440 year: 1984 ident: 25040020_CR6 publication-title: J. Chromatogr., A doi: 10.1016/S0021-9673(01)96107-2 – volume: 36 start-page: 372 year: 1981 ident: 25040020_CR2 publication-title: Farmaco – volume: 19 start-page: 297 year: 1996 ident: 25040020_CR5 publication-title: Arch. Pharm. Res. doi: 10.1007/BF02976244 – ident: 25040020_CR1 – volume: 19 start-page: 32 year: 2005 ident: 25040020_CR3 publication-title: Biomed. Chromatogr. doi: 10.1002/bmc.412 |
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| SubjectTerms | Analytical Chemistry Benzofurans - administration & dosage Benzofurans - blood Benzofurans - pharmacokinetics Chemical Precipitation Chemistry Chromatography, Liquid Humans Ionization Linear Models Liquid chromatography Mass spectrometry Niflumic Acid - administration & dosage Niflumic Acid - blood Niflumic Acid - pharmacokinetics Proteins - chemistry Pyridines - administration & dosage Pyridines - blood Pyridines - pharmacokinetics Sensitivity and Specificity Solvents - chemistry Tandem Mass Spectrometry Time Factors |
| Title | Determination of Talniflumate and Niflumic Acid in Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry |
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