Resting-state synchrony between the retrosplenial cortex and anterior medial cortical structures relates to memory complaints in subjective cognitive impairment

• Published in: Neurobiology of aging Vol. 36; no. 6; pp. 2145 - 2152
• Main Authors: Yasuno, Fumihiko, Kazui, Hiroaki, Yamamoto, Akihide, Morita, Naomi, Kajimoto, Katsufumi, Ihara, Masafumi, Taguchi, Akihiko, Matsuoka, Kiwamu, Kosaka, Jun, Tanaka, Toshihisa, Kudo, Takashi, Takeda, Masatoshi, Nagatsuka, Kazuyuki, Iida, Hidehiro, Kishimoto, Toshifumi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2015
• Subjects: Aged; Amyloid imaging; Cerebral Cortex - pathology; Cerebral Cortex - physiopathology; Cognition Disorders - pathology; Cognition Disorders - physiopathology; Cognition Disorders - psychology; Cortical midline structures; Diffusion Tensor Imaging; Diffusion tensor imaging (DTI); Female; Humans; Internal Medicine; Male; Memory - physiology; Middle Aged; Neurology; Rest - physiology; Resting-state functional MRI (fMRI); Self-referential processing; Subjective cognitive impairment (SCI); White Matter - pathology; White Matter - physiopathology; Self-referential processing; Diffusion tensor imaging (DTI); Resting-state functional MRI (fMRI); Subjective cognitive impairment (SCI); Amyloid imaging; Cortical midline structures

Subjective cognitive impairment (SCI) is a clinical state characterized by subjective cognitive deficits without cognitive impairment. To test the hypothesis that this state might involve dysfunction of self-referential processing mediated by cortical midline structures, we investigated abnormalitie...