Application of polyglycolic acid sheets and basic fibroblast growth factor to prevent esophageal stricture after endoscopic submucosal dissection in pigs

• Published in: Journal of Gastroenterology Vol. 58; no. 11; pp. 1094 - 1104
• Main Authors: Nishimura, Yusuke, Ono, Masayoshi, Okubo, Naoto, Sone, Takayuki, Higashino, Masayuki, Matsumoto, Shogo, Kubo, Marina, Yamamoto, Keiko, Ono, Shoko, Ohnishi, Shunsuke, Sakamoto, Naoya
• Format: Journal Article
• Language: English
• Published: Singapore Springer Science and Business Media LLC 01.11.2023; Springer Nature Singapore; Springer; Springer Nature B.V
• Subjects: Abdominal Surgery; Antibodies; Calponin; Care and treatment; Colorectal Surgery; Dexmedetomidine; Dissection; Endoscopy; Esophageal cancer; Esophagus; Evaluation; Fibrin; Fibroblast growth factor 2; Fibroblast growth factors; Fibroblasts; Fibrosis; Gastroenterology; Glycolic acid; Growth factors; Hepatology; Medicine; Medicine & Public Health; Original Article—Alimentary Tract; Original —Alimentary Tract; Polyglycolic acid; Spraying; Stenosis; Stricture; Surgery; Surgical Oncology; Swine; Viral antibodies; Wound healing; Wounds and injuries; Polyglycolic acid; Endoscopic submucosal dissection; Basic fibroblast growth factor; Esophageal stricture
• ISSN: 0944-1174; 1435-5922; 1435-5922
• DOI: 10.1007/s00535-023-02032-4

Background Endoscopic submucosal dissection (ESD) has been the first-line treatment for early-stage esophageal cancer. However, it often causes postoperative stricture in cases requiring wide dissection. Basic fibroblast growth factor (bFGF) reportedly has anti-scarring effects during cutaneous woun...