Changes in PIK3CA mutation status are not associated with recurrence, metastatic disease or progression in endocrine-treated breast cancer

• Published in: Breast cancer research and treatment Vol. 147; no. 1; pp. 211 - 219
• Main Authors: Arthur, L. M., Turnbull, A. K., Renshaw, L., Keys, J., Thomas, J. S., Wilson, T. R., Lackner, M. R., Sims, A. H., Dixon, J. M.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2014; Springer; Springer Nature B.V
• Subjects: Adenocarcinoma - drug therapy; Adenocarcinoma - genetics; Adenocarcinoma - mortality; Adenocarcinoma - secondary; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal - therapeutic use; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - genetics; Breast Neoplasms - mortality; Breast Neoplasms - pathology; Brief Report; Cancer metastasis; Cancer research; Cancer therapies; Carcinoma, Ductal, Breast - drug therapy; Carcinoma, Ductal, Breast - genetics; Carcinoma, Ductal, Breast - mortality; Carcinoma, Ductal, Breast - secondary; Carcinoma, Intraductal, Noninfiltrating - drug therapy; Carcinoma, Intraductal, Noninfiltrating - genetics; Carcinoma, Intraductal, Noninfiltrating - mortality; Carcinoma, Intraductal, Noninfiltrating - secondary; Carcinoma, Lobular - drug therapy; Carcinoma, Lobular - genetics; Carcinoma, Lobular - mortality; Carcinoma, Lobular - secondary; Care and treatment; Class I Phosphatidylinositol 3-Kinases; Cohort Studies; Development and progression; Disease Progression; Diseases; Drug resistance; Endocrine therapy; Female; Follow-Up Studies; Genes; Genetic aspects; Humans; Immunohistochemistry; Medicine; Medicine & Public Health; Metastasis; Middle Aged; Mutation; Mutation - genetics; Neoplasm Invasiveness; Neoplasm Recurrence, Local - drug therapy; Neoplasm Recurrence, Local - genetics; Neoplasm Recurrence, Local - mortality; Neoplasm Recurrence, Local - pathology; Neoplasm Staging; Neoplasms, Hormone-Dependent - drug therapy; Neoplasms, Hormone-Dependent - genetics; Neoplasms, Hormone-Dependent - mortality; Neoplasms, Hormone-Dependent - secondary; Neoplasms, Second Primary - drug therapy; Neoplasms, Second Primary - genetics; Neoplasms, Second Primary - mortality; Neoplasms, Second Primary - secondary; Oncology; Phosphatidylinositol 3-Kinase - genetics; Phosphatidylinositol 3-Kinases - genetics; Prognosis; PTEN Phosphohydrolase - genetics; Recurrence (Disease); Relapse; Survival Rate; Resistance; PTEN; Endocrine; Breast cancer; Mutation; PIK3CA

The phosphatidylinositol-3-kinase pathway plays an important role in proliferation, migration and survival in breast cancer and may play a role in resistance to endocrine therapy. Pathway activation occurs as a result of mutations in PIK3CA or loss of functional PTEN. Matched primary and recurrent s...