Vasorelaxant and Hypotensive Effects of Tilisolol Hydrochloride (N-696) in Isolated Rat Thoracic Aorta and Pithed Rats

• Published in: Japanese Journal of Pharmacology Vol. 57; no. 3; pp. 367 - 375
• Main Authors: Sugai, Toshiji, Kojima, Kazuko, Iwakami, Naomi, Suzuki, Yoshikuni
• Format: Journal Article
• Language: English; Japanese
• Published: Kyoto The Japanese Pharmacological Society 1991; Japanese Pharmacological Society
• Subjects: Adrenergic beta-Antagonists - pharmacology; Animals; Antihypertensive agents; Aorta, Thoracic - drug effects; Benzopyrans - pharmacology; Biological and medical sciences; blood pressure; Blood Pressure - drug effects; Cardiovascular system; Cromakalim; Dose-Response Relationship, Drug; Glyburide - pharmacology; Hypotension - chemically induced; In Vitro Techniques; induction; Isoquinolines - antagonists & inhibitors; Isoquinolines - pharmacology; Male; Medical sciences; Pharmacology. Drug treatments; Pyrroles - pharmacology; Rats; Rats, Inbred Strains; reduction; tilisolol hydrochloride; Vasodilator Agents - antagonists & inhibitors; Vasodilator Agents - pharmacology; vasorelaxation; Vasodilator agent; Rat; Spinal animal; Rodentia; Smooth muscle; Muscle contraction; In vitro; Biological activity; Thoracic aorta; Vertebrata; Mammalia; Antihypertensive agent; Beta blocking agent

Vasorelaxant and hypotensive effects of tilisolol hydrochloride (N-696) in isolated rat thoracic aorta and pithed rats were investigated. In rat thoracic aorta pre-contracted with KCl (20 mM), tilisolol (10-5-10-3 M) produced concentration-related relaxation, but nadolol and atenolol did not signifi...