α1-giardin based live heterologous vaccine protects against Giardia lamblia infection in a murine model

• Published in: Vaccine Vol. 29; no. 51; pp. 9529 - 9537
• Main Authors: Jenikova, Gabriela, Hruz, Petr, Andersson, Mattias K., Tejman-Yarden, Noa, Ferreira, Patricia C.D., Andersen, Yolanda S., Davids, Barbara J., Gillin, Frances D., Svärd, Staffan G., Curtiss, Roy, Eckmann, Lars
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 28.11.2011; Elsevier
• Subjects: Administration, Oral; Allergy and Immunology; amino acid sequences; Animal models; Animals; Antibodies, Protozoan - biosynthesis; antigens; Antigens, Protozoan - immunology; Applied microbiology; Biological and medical sciences; blood serum; cats; cholera toxin; Cholera Toxin - immunology; cross reaction; Cytoskeletal Proteins - administration & dosage; Cytoskeletal Proteins - immunology; dogs; Fundamental and applied biological sciences. Psychology; Giardia lamblia; Giardia lamblia - immunology; Giardiasis; Giardiasis - immunology; Giardiasis - prevention & control; Human protozoal diseases; humans; immunization; immunoglobulin A; immunoglobulin G; Infectious diseases; Live oral vaccines; Medical sciences; Mice; Mice, Inbred BALB C; Microbiology; oral administration; ornithine; Ornithine Carbamoyltransferase - administration & dosage; Ornithine Carbamoyltransferase - immunology; Parasitic diseases; Parasitic diseases due to ciliates and flagellates; phosphopyruvate hydratase; Phosphopyruvate Hydratase - administration & dosage; Phosphopyruvate Hydratase - immunology; Protozoal diseases; Protozoan Proteins - administration & dosage; Protozoan Proteins - immunology; Protozoan Vaccines - administration & dosage; Protozoan Vaccines - immunology; Salmonella Typhimurium; Salmonella typhimurium - genetics; vaccine development; vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccines, Synthetic - administration & dosage; Vaccines, Synthetic - immunology; OCT; VSP; Animal models; Live oral vaccines; ADI; Giardiasis; arginine deiminase; ornithine carbamoyl transferase; variable surface protein; Infection; Animal model; Protozoal disease; Digestive diseases; Intestinal disease; Vaccine; Parasitosis

► Giardia lamblia is a leading protozoan cause of diarrheal disease worldwide. ► Preventive medical strategies are not available against giardiasis. ► Immunization of mice with a live α1-giardin vaccine protected against infection. ► α1-giardin is highly conserved between divergent Giardia isolates....