α1-giardin based live heterologous vaccine protects against Giardia lamblia infection in a murine model
► Giardia lamblia is a leading protozoan cause of diarrheal disease worldwide. ► Preventive medical strategies are not available against giardiasis. ► Immunization of mice with a live α1-giardin vaccine protected against infection. ► α1-giardin is highly conserved between divergent Giardia isolates....
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| Published in | Vaccine Vol. 29; no. 51; pp. 9529 - 9537 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Kidlington
Elsevier Ltd
28.11.2011
Elsevier |
| Subjects | |
| Online Access | Get full text |
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| Abstract | ► Giardia lamblia is a leading protozoan cause of diarrheal disease worldwide. ► Preventive medical strategies are not available against giardiasis. ► Immunization of mice with a live α1-giardin vaccine protected against infection. ► α1-giardin is highly conserved between divergent Giardia isolates.
Giardia lamblia is a leading protozoan cause of diarrheal disease worldwide, yet preventive medical strategies are not available. A crude veterinary vaccine has been licensed for cats and dogs, but no defined human vaccine is available. We tested the vaccine potential of three conserved antigens previously identified in human and murine giardiasis, α1-giardin, α-enolase, and ornithine carbamoyl transferase, in a murine model of G. lamblia infection. Live recombinant attenuated Salmonella enterica Serovar Typhimurium vaccine strains were constructed that stably expressed each antigen, maintained colonization capacity, and sustained total attenuation in the host. Oral administration of the vaccine strains induced antigen-specific serum IgG, particularly IgG2A, and mucosal IgA for α1-giardin and α-enolase, but not for ornithine carbamoyl transferase. Immunization with the α1-giardin vaccine induced significant protection against subsequent G. lamblia challenge, which was further enhanced by boosting with cholera toxin or sublingual α1-giardin administration. The α-enolase vaccine afforded no protection. Analysis of α1-giardin from divergent assemblage A and B isolates of G. lamblia revealed >97% amino acid sequence conservation and immunological cross-reactivity, further supporting the potential utility of this antigen in vaccine development. Together. These results indicate that α1-giardin is a suitable candidate antigen for a vaccine against giardiasis. |
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| AbstractList | Giardia lamblia is a leading protozoan cause of diarrheal disease worldwide, yet preventive medical strategies are not available. A crude veterinary vaccine has been licensed for cats and dogs, but no defined human vaccine is available. We tested the vaccine potential of three conserved antigens previously identified in human and murine giardiasis, α1-giardin, α-enolase, and ornithine carbamoyl transferase, in a murine model of G. lamblia infection. Live recombinant attenuated Salmonella enterica Serovar Typhimurium vaccine strains were constructed that stably expressed each antigen, maintained colonization capacity, and sustained total attenuation in the host. Oral administration of the vaccine strains induced antigen-specific serum IgG, particularly IgG₂A, and mucosal IgA for α1-giardin and α-enolase, but not for ornithine carbamoyl transferase. Immunization with the α1-giardin vaccine induced significant protection against subsequent G. lamblia challenge, which was further enhanced by boosting with cholera toxin or sublingual α1-giardin administration. The α-enolase vaccine afforded no protection. Analysis of α1-giardin from divergent assemblage A and B isolates of G. lamblia revealed >97% amino acid sequence conservation and immunological cross-reactivity, further supporting the potential utility of this antigen in vaccine development. Together. These results indicate that α1-giardin is a suitable candidate antigen for a vaccine against giardiasis. Giardia lamblia is a leading protozoan cause of diarrheal disease worldwide, yet preventive medical strategies are not available. A crude veterinary vaccine has been licensed for cats and dogs, but no defined human vaccine is available. We tested the vaccine potential of three conserved antigens previously identified in human and murine giardiasis, α1-giardin, α-enolase, and ornithine carbamoyl transferase, in a murine model of G. lamblia infection. Live recombinant attenuated Salmonella enterica Serovar Typhimurium vaccine strains were constructed that stably expressed each antigen, maintained colonization capacity, and sustained total attenuation in the host. Oral administration of the vaccine strains induced antigen-specific serum IgG, particularly IgG(2A), and mucosal IgA for α1-giardin and α-enolase, but not for ornithine carbamoyl transferase. Immunization with the α1-giardin vaccine induced significant protection against subsequent G. lamblia challenge, which was further enhanced by boosting with cholera toxin or sublingual α1-giardin administration. The α-enolase vaccine afforded no protection. Analysis of α1-giardin from divergent assemblage A and B isolates of G. lamblia revealed >97% amino acid sequence conservation and immunological cross-reactivity, further supporting the potential utility of this antigen in vaccine development. Together. These results indicate that α1-giardin is a suitable candidate antigen for a vaccine against giardiasis.Giardia lamblia is a leading protozoan cause of diarrheal disease worldwide, yet preventive medical strategies are not available. A crude veterinary vaccine has been licensed for cats and dogs, but no defined human vaccine is available. We tested the vaccine potential of three conserved antigens previously identified in human and murine giardiasis, α1-giardin, α-enolase, and ornithine carbamoyl transferase, in a murine model of G. lamblia infection. Live recombinant attenuated Salmonella enterica Serovar Typhimurium vaccine strains were constructed that stably expressed each antigen, maintained colonization capacity, and sustained total attenuation in the host. Oral administration of the vaccine strains induced antigen-specific serum IgG, particularly IgG(2A), and mucosal IgA for α1-giardin and α-enolase, but not for ornithine carbamoyl transferase. Immunization with the α1-giardin vaccine induced significant protection against subsequent G. lamblia challenge, which was further enhanced by boosting with cholera toxin or sublingual α1-giardin administration. The α-enolase vaccine afforded no protection. Analysis of α1-giardin from divergent assemblage A and B isolates of G. lamblia revealed >97% amino acid sequence conservation and immunological cross-reactivity, further supporting the potential utility of this antigen in vaccine development. Together. These results indicate that α1-giardin is a suitable candidate antigen for a vaccine against giardiasis. ► Giardia lamblia is a leading protozoan cause of diarrheal disease worldwide. ► Preventive medical strategies are not available against giardiasis. ► Immunization of mice with a live α1-giardin vaccine protected against infection. ► α1-giardin is highly conserved between divergent Giardia isolates. Giardia lamblia is a leading protozoan cause of diarrheal disease worldwide, yet preventive medical strategies are not available. A crude veterinary vaccine has been licensed for cats and dogs, but no defined human vaccine is available. We tested the vaccine potential of three conserved antigens previously identified in human and murine giardiasis, α1-giardin, α-enolase, and ornithine carbamoyl transferase, in a murine model of G. lamblia infection. Live recombinant attenuated Salmonella enterica Serovar Typhimurium vaccine strains were constructed that stably expressed each antigen, maintained colonization capacity, and sustained total attenuation in the host. Oral administration of the vaccine strains induced antigen-specific serum IgG, particularly IgG2A, and mucosal IgA for α1-giardin and α-enolase, but not for ornithine carbamoyl transferase. Immunization with the α1-giardin vaccine induced significant protection against subsequent G. lamblia challenge, which was further enhanced by boosting with cholera toxin or sublingual α1-giardin administration. The α-enolase vaccine afforded no protection. Analysis of α1-giardin from divergent assemblage A and B isolates of G. lamblia revealed >97% amino acid sequence conservation and immunological cross-reactivity, further supporting the potential utility of this antigen in vaccine development. Together. These results indicate that α1-giardin is a suitable candidate antigen for a vaccine against giardiasis. Giardia lamblia is a leading protozoan cause of diarrheal disease worldwide, yet preventive medical strategies are not available. A crude veterinary vaccine has been licensed for cats and dogs, but no defined human vaccine is available. We tested the vaccine potential of three conserved antigens previously identified in human and murine giardiasis, α1-giardin, α-enolase, and ornithine carbamoyl transferase, in a murine model of G. lamblia infection. Live recombinant attenuated Salmonella enterica Serovar Typhimurium vaccine strains were constructed that stably expressed each antigen, maintained colonization capacity, and sustained total attenuation in the host. Oral administration of the vaccine strains induced antigen-specific serum IgG, particularly IgG(2A), and mucosal IgA for α1-giardin and α-enolase, but not for ornithine carbamoyl transferase. Immunization with the α1-giardin vaccine induced significant protection against subsequent G. lamblia challenge, which was further enhanced by boosting with cholera toxin or sublingual α1-giardin administration. The α-enolase vaccine afforded no protection. Analysis of α1-giardin from divergent assemblage A and B isolates of G. lamblia revealed >97% amino acid sequence conservation and immunological cross-reactivity, further supporting the potential utility of this antigen in vaccine development. Together. These results indicate that α1-giardin is a suitable candidate antigen for a vaccine against giardiasis. Highlights ► Giardia lamblia is a leading protozoan cause of diarrheal disease worldwide. ► Preventive medical strategies are not available against giardiasis. ► Immunization of mice with a live α1-giardin vaccine protected against infection. ► α1-giardin is highly conserved between divergent Giardia isolates. Giardia lamblia is a leading protozoan cause of diarrheal disease worldwide, yet preventive medical strategies are not available. A crude veterinary vaccine has been licensed for cats and dogs, but no defined human vaccine is available. We tested the vaccine potential of three conserved antigens previously identified in human and murine giardiasis, α1-giardin, α-enolase, and ornithine carbamoyl transferase, in a murine model of G. lamblia infection. Live recombinant attenuated Salmonella enterica Serovar Typhimurium vaccine strains were constructed that stably expressed each antigen, maintained colonization capacity, and sustained total attenuation in the host. Oral administration of the vaccine strains induced antigen-specific serum IgG, particularly IgG 2A , and mucosal IgA for α1-giardin and α-enolase, but not for ornithine carbamoyl transferase. Immunization with the α1-giardin vaccine induced significant protection against subsequent G. lamblia challenge, which was further enhanced by boosting with cholera toxin or sublingual α1-giardin administration. The α-enolase vaccine afforded no protection. Analysis of α1-giardin from divergent assemblage A and B isolates of G. lamblia revealed >97% amino acid sequence conservation and immunological cross-reactivity, further supporting the potential utility of this antigen in vaccine development. Together. these results indicate that α1-giardin is a suitable candidate antigen for a vaccine against giardiasis. |
| Author | Ferreira, Patricia C.D. Davids, Barbara J. Svärd, Staffan G. Eckmann, Lars Andersson, Mattias K. Andersen, Yolanda S. Hruz, Petr Curtiss, Roy Jenikova, Gabriela Gillin, Frances D. Tejman-Yarden, Noa |
| AuthorAffiliation | a Departments of Medicine and Pathology, University of California, San Diego, La Jolla, California 92093 b Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden c Biodesign Institute, Center for Infectious Diseases and Vaccinology, Arizona State University, Tempe, Arizona 85287 |
| AuthorAffiliation_xml | – name: c Biodesign Institute, Center for Infectious Diseases and Vaccinology, Arizona State University, Tempe, Arizona 85287 – name: b Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden – name: a Departments of Medicine and Pathology, University of California, San Diego, La Jolla, California 92093 |
| Author_xml | – sequence: 1 givenname: Gabriela surname: Jenikova fullname: Jenikova, Gabriela organization: Departments of Medicine and Pathology, University of California, San Diego, La Jolla, CA 92093, United States – sequence: 2 givenname: Petr surname: Hruz fullname: Hruz, Petr organization: Departments of Medicine and Pathology, University of California, San Diego, La Jolla, CA 92093, United States – sequence: 3 givenname: Mattias K. surname: Andersson fullname: Andersson, Mattias K. organization: Departments of Medicine and Pathology, University of California, San Diego, La Jolla, CA 92093, United States – sequence: 4 givenname: Noa surname: Tejman-Yarden fullname: Tejman-Yarden, Noa organization: Departments of Medicine and Pathology, University of California, San Diego, La Jolla, CA 92093, United States – sequence: 5 givenname: Patricia C.D. surname: Ferreira fullname: Ferreira, Patricia C.D. organization: Departments of Medicine and Pathology, University of California, San Diego, La Jolla, CA 92093, United States – sequence: 6 givenname: Yolanda S. surname: Andersen fullname: Andersen, Yolanda S. organization: Departments of Medicine and Pathology, University of California, San Diego, La Jolla, CA 92093, United States – sequence: 7 givenname: Barbara J. surname: Davids fullname: Davids, Barbara J. organization: Departments of Medicine and Pathology, University of California, San Diego, La Jolla, CA 92093, United States – sequence: 8 givenname: Frances D. surname: Gillin fullname: Gillin, Frances D. organization: Departments of Medicine and Pathology, University of California, San Diego, La Jolla, CA 92093, United States – sequence: 9 givenname: Staffan G. surname: Svärd fullname: Svärd, Staffan G. organization: Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden – sequence: 10 givenname: Roy surname: Curtiss fullname: Curtiss, Roy organization: Biodesign Institute, Center for Infectious Diseases and Vaccinology, Arizona State University, Tempe, AZ 85287, United States – sequence: 11 givenname: Lars surname: Eckmann fullname: Eckmann, Lars email: leckmann@ucsd.edu organization: Departments of Medicine and Pathology, University of California, San Diego, La Jolla, CA 92093, United States |
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| Cites_doi | 10.1016/j.ijpara.2007.10.004 10.1128/JB.154.1.269-277.1983 10.1074/jbc.273.23.14503 10.1128/IAI.00720-08 10.1051/parasite/2008153261 10.1046/j.1462-5822.2003.00344.x 10.1128/IAI.62.8.3583-3585.1994 10.1128/IAI.01623-07 10.1645/GE-1851R.1 10.1016/S0020-7519(03)00201-7 10.1093/jac/14.5.449 10.1038/nm.2141 10.1111/j.1365-3024.2005.00758.x 10.1086/375356 10.1128/IAI.69.9.5278-5285.2001 10.1172/JCI0216941 10.1016/S0020-7519(97)00064-7 10.1086/317659 10.1016/j.ijpara.2004.12.009 10.1128/IAI.72.8.4763-4771.2004 10.1083/jcb.109.5.2323 10.1093/bioinformatics/btm404 10.1016/S0169-4758(99)01623-3 10.4049/jimmunol.178.2.1059 10.1128/IAI.71.10.5662-5669.2003 10.1371/journal.ppat.1000560 10.1046/j.1365-2958.2002.03029.x 10.1016/j.vetpar.2007.01.013 10.1128/IAI.68.1.170-175.2000 10.1016/j.molbiopara.2008.02.005 10.1080/13693780310001644653 10.1128/IAI.00444-10 10.3201/eid0911.030084 10.1128/CMR.13.1.35-54.2000 10.1093/oxfordjournals.molbev.a026204 10.1016/0890-8508(92)90002-F 10.1128/IAI.70.1.11-18.2002 10.1016/j.micinf.2008.10.002 10.1016/j.ijpharm.2008.04.036 10.1038/nbt0688-693 10.1136/gut.2006.107771 10.1073/pnas.0803801105 10.1016/j.ijmm.2007.08.006 10.1126/science.1143837 10.1016/0035-9203(94)90119-8 10.4161/hv.4.1.5560 10.1128/IAI.00536-10 10.1128/IAI.70.4.1739-1749.2002 10.4049/jimmunol.177.9.6281 10.1046/j.1365-3024.2003.00607.x 10.1093/infdis/156.6.974 10.1016/0020-7519(89)90026-X 10.1038/nature07585 10.1615/CritRevImmunol.v30.i3.30 10.1016/j.vaccine.2007.10.012 10.2166/wh.2006.002 10.1016/0264-410X(92)90414-F 10.1128/IAI.74.4.2473-2476.2006 10.4049/jimmunol.173.5.3375 |
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| References | Rivero, Saura, Prucca, Carranza, Torri, Lujan (bib0085) 2010; 16 Ebensen, Guzman (bib0120) 2008; 4 Monis, Andrews, Mayrhofer, Ey (bib0195) 1999; 16 Boreham, Phillips, Shepherd (bib0145) 1984; 14 Morrison, McArthur, Gillin, Aley, Adam, Olsen (bib0090) 2007; 317 Palm, Weiland, Griffiths, Ljungstrom, Svard (bib0100) 2003; 187 Xin, Wanda, Li, Wang, Mo, Curtiss (bib0285) 2008; 76 Tellez, Palm, Weiland, Aleman, Winiecka-Krusnell, Linder (bib0105) 2005; 27 Davids, Palm, Housley, Smith, Andersen, Martin (bib0110) 2006; 177 Vinayak, Kum, Khanna, Khuller (bib0220) 1992; 10 Stager, Gottstein, Muller (bib0135) 1997; 27 Nash, Herrington, Losonsky, Levine (bib0015) 1987; 156 Larocque, Nakagaki, Lee, Abdul-Wahid, Faubert (bib0045) 2003; 71 Kang, Srinivasan, Curtiss (bib0165) 2002; 70 Yang, Hinnebusch, Trunkle, Bosio, Suo, Tighe (bib0300) 2007; 178 Eko, He, Brown, McMillan, Ifere, Ananaba (bib0290) 2004; 173 Buret (bib0235) 2007; 56 Olson, Ceri, Morck (bib0030) 2000; 16 Lee, Abdul-Wahid, Faubert (bib0050) 2009; 11 Franzen, Jerlstrom-Hultqvist, Castro, Sherwood, Ankarklev, Reiner (bib0095) 2009; 5 Byrd, Conrad, Nash (bib0140) 1994; 62 Curtiss (bib0115) 2002; 110 Ringqvist, Palm, Skarin, Hehl, Weiland, Davids (bib0175) 2008; 159 Singer, Nash (bib0215) 2000; 68 Majewska (bib0010) 1994; 88 Buret (bib0025) 2008; 15 Montagnoli, Sandini, Bacci, Romani, La Valle (bib0280) 2004; 42 Karanis, Kourenti, Smith (bib0005) 2007; 5 Wang, Li, Scarpellini, Kong, Shi, Baek (bib0210) 2010; 78 Prucca, Slavin, Quiroga, Elias, Rivero, Saura (bib0080) 2008; 456 Weiland, McArthur, Morrison, Sogin, Svard (bib0245) 2005; 35 Abdul-Wahid, Faubert (bib0055) 2007; 25 Nash (bib0065) 2002; 45 Jenkins, O’Brien, Murphy, Schwarz, Miska, Rosenthal (bib0255) 2009; 95 Sulaiman, Fayer, Bern, Gilman, Trout, Schantz (bib0230) 2003; 9 von Allmen, Bienz, Hemphill, Muller (bib0185) 2004; 72 Rahn, De Grandis, Clarke, McEwen, Galan, Ginocchio (bib0190) 1992; 6 Cheminay, Hensel (bib0130) 2008; 298 Langford, Housley, Boes, Chen, Kagnoff, Gillin (bib0225) 2002; 70 Weiland, Palm, Griffiths, McCaffery, Svard (bib0260) 2003; 33 Uehlinger, O’Handley, Greenwood, Guselle, Gabor, Van Velsen (bib0035) 2007; 146 Hitchcock, Brown (bib0170) 1983; 154 Perrie, Mohammed, Kirby, McNeil, Bramwell (bib0125) 2008; 364 Veiga-Malta, Duarte, Dinis, Tavares, Videira, Ferreira (bib0265) 2004; 6 Andersen, Gillin, Eckmann (bib0275) 2006; 74 Li, Wang, Xin, Scarpellini, Shi, Gunn (bib0155) 2008; 76 Curtiss, Xin, Li, Kong, Wanda, Gunn (bib0205) 2010; 30 Raghavan, Ostberg, Flach, Ekman, Blomquist, Czerkinsky (bib0180) 2010; 78 Singer, Elmendorf, Conrad, Nash (bib0070) 2001; 183 Bienz, Siles-Lucas, Wittwer, Muller (bib0075) 2001; 69 Abdul-Wahid, Faubert (bib0040) 2008; 38 Peattie, Alonso, Hein, Caulfield (bib0250) 1989; 109 Gaucher, Chadee (bib0240) 2003; 25 Nakayama, Kelly, Curtiss (bib0160) 1988; 6 Kong, Wanda, Zhang, Bollen, Tinge, Roland (bib0295) 2008; 105 Capon, Upcroft, Boreham, Cottis, Bundesen (bib0150) 1989; 19 Flanagan (bib0020) 1992; 109 Faubert (bib0060) 2000; 13 Larkin, Blackshields, Brown, Chenna, McGettigan, McWilliam (bib0200) 2007; 23 Pancholi, Fischetti (bib0270) 1998; 273 Veiga-Malta (10.1016/j.vaccine.2011.09.126_bib0265) 2004; 6 Langford (10.1016/j.vaccine.2011.09.126_bib0225) 2002; 70 Tellez (10.1016/j.vaccine.2011.09.126_bib0105) 2005; 27 Xin (10.1016/j.vaccine.2011.09.126_bib0285) 2008; 76 Rivero (10.1016/j.vaccine.2011.09.126_bib0085) 2010; 16 Jenkins (10.1016/j.vaccine.2011.09.126_bib0255) 2009; 95 Curtiss (10.1016/j.vaccine.2011.09.126_bib0205) 2010; 30 Larocque (10.1016/j.vaccine.2011.09.126_bib0045) 2003; 71 Hitchcock (10.1016/j.vaccine.2011.09.126_bib0170) 1983; 154 Franzen (10.1016/j.vaccine.2011.09.126_bib0095) 2009; 5 Pancholi (10.1016/j.vaccine.2011.09.126_bib0270) 1998; 273 Buret (10.1016/j.vaccine.2011.09.126_bib0235) 2007; 56 Li (10.1016/j.vaccine.2011.09.126_bib0155) 2008; 76 Yang (10.1016/j.vaccine.2011.09.126_bib0300) 2007; 178 Boreham (10.1016/j.vaccine.2011.09.126_bib0145) 1984; 14 Nakayama (10.1016/j.vaccine.2011.09.126_bib0160) 1988; 6 Capon (10.1016/j.vaccine.2011.09.126_bib0150) 1989; 19 Nash (10.1016/j.vaccine.2011.09.126_bib0065) 2002; 45 Singer (10.1016/j.vaccine.2011.09.126_bib0070) 2001; 183 Prucca (10.1016/j.vaccine.2011.09.126_bib0080) 2008; 456 Faubert (10.1016/j.vaccine.2011.09.126_bib0060) 2000; 13 Majewska (10.1016/j.vaccine.2011.09.126_bib0010) 1994; 88 Lee (10.1016/j.vaccine.2011.09.126_bib0050) 2009; 11 von Allmen (10.1016/j.vaccine.2011.09.126_bib0185) 2004; 72 Sulaiman (10.1016/j.vaccine.2011.09.126_bib0230) 2003; 9 Karanis (10.1016/j.vaccine.2011.09.126_bib0005) 2007; 5 Cheminay (10.1016/j.vaccine.2011.09.126_bib0130) 2008; 298 Andersen (10.1016/j.vaccine.2011.09.126_bib0275) 2006; 74 Curtiss (10.1016/j.vaccine.2011.09.126_bib0115) 2002; 110 Davids (10.1016/j.vaccine.2011.09.126_bib0110) 2006; 177 Morrison (10.1016/j.vaccine.2011.09.126_bib0090) 2007; 317 Weiland (10.1016/j.vaccine.2011.09.126_bib0245) 2005; 35 Flanagan (10.1016/j.vaccine.2011.09.126_bib0020) 1992; 109 Montagnoli (10.1016/j.vaccine.2011.09.126_bib0280) 2004; 42 Raghavan (10.1016/j.vaccine.2011.09.126_bib0180) 2010; 78 Monis (10.1016/j.vaccine.2011.09.126_bib0195) 1999; 16 Perrie (10.1016/j.vaccine.2011.09.126_bib0125) 2008; 364 Olson (10.1016/j.vaccine.2011.09.126_bib0030) 2000; 16 Byrd (10.1016/j.vaccine.2011.09.126_bib0140) 1994; 62 Uehlinger (10.1016/j.vaccine.2011.09.126_bib0035) 2007; 146 Kong (10.1016/j.vaccine.2011.09.126_bib0295) 2008; 105 Rahn (10.1016/j.vaccine.2011.09.126_bib0190) 1992; 6 Ringqvist (10.1016/j.vaccine.2011.09.126_bib0175) 2008; 159 Vinayak (10.1016/j.vaccine.2011.09.126_bib0220) 1992; 10 Wang (10.1016/j.vaccine.2011.09.126_bib0210) 2010; 78 Eko (10.1016/j.vaccine.2011.09.126_bib0290) 2004; 173 Bienz (10.1016/j.vaccine.2011.09.126_bib0075) 2001; 69 Kang (10.1016/j.vaccine.2011.09.126_bib0165) 2002; 70 Weiland (10.1016/j.vaccine.2011.09.126_bib0260) 2003; 33 Nash (10.1016/j.vaccine.2011.09.126_bib0015) 1987; 156 Larkin (10.1016/j.vaccine.2011.09.126_bib0200) 2007; 23 Stager (10.1016/j.vaccine.2011.09.126_bib0135) 1997; 27 Abdul-Wahid (10.1016/j.vaccine.2011.09.126_bib0055) 2007; 25 Buret (10.1016/j.vaccine.2011.09.126_bib0025) 2008; 15 Singer (10.1016/j.vaccine.2011.09.126_bib0215) 2000; 68 Ebensen (10.1016/j.vaccine.2011.09.126_bib0120) 2008; 4 Gaucher (10.1016/j.vaccine.2011.09.126_bib0240) 2003; 25 Peattie (10.1016/j.vaccine.2011.09.126_bib0250) 1989; 109 Abdul-Wahid (10.1016/j.vaccine.2011.09.126_bib0040) 2008; 38 Palm (10.1016/j.vaccine.2011.09.126_bib0100) 2003; 187 18037419 - Int J Parasitol. 2008 May;38(6):691-703 17339241 - Gut. 2007 Mar;56(3):316-7 12393839 - J Clin Invest. 2002 Oct;110(8):1061-6 18458067 - Infect Immun. 2008 Jul;76(7):3241-54 11500396 - Infect Immun. 2001 Sep;69(9):5278-85 17996337 - Vaccine. 2007 Dec 5;25(50):8372-83 18765737 - Infect Immun. 2008 Nov;76(11):5238-46 18992359 - Microbes Infect. 2009 Jan;11(1):20-8 9292314 - Int J Parasitol. 1997 Aug;27(8):965-71 15862575 - Int J Parasitol. 2005 May;35(6):617-26 1539457 - Vaccine. 1992;10(1):21-7 14500486 - Infect Immun. 2003 Oct;71(10):5662-9 17056558 - J Immunol. 2006 Nov 1;177(9):6281-90 11087204 - J Infect Dis. 2001 Jan 1;183(1):119-24 9603964 - J Biol Chem. 1998 Jun 5;273(23):14503-15 17901334 - Science. 2007 Sep 28;317(5846):1921-6 15473356 - Med Mycol. 2004 Aug;42(4):319-24 14718089 - Emerg Infect Dis. 2003 Nov;9(11):1444-52 20696831 - Infect Immun. 2010 Oct;78(10):4251-60 17402277 - J Water Health. 2007 Mar;5(1):1-38 14678332 - Cell Microbiol. 2004 Jan;6(1):79-88 2651342 - Int J Parasitol. 1989 Feb;19(1):91-8 10603384 - Infect Immun. 2000 Jan;68(1):170-5 1499664 - Epidemiol Infect. 1992 Aug;109(1):1-22 15987339 - Parasite Immunol. 2005 May;27(5):163-9 15271938 - Infect Immun. 2004 Aug;72(8):4763-71 12139606 - Mol Microbiol. 2002 Aug;45(3):585-90 20370633 - Crit Rev Immunol. 2010;30(3):255-70 12791100 - Parasite Immunol. 2003 Feb;25(2):55-8 14527517 - Int J Parasitol. 2003 Oct;33(12):1341-51 2808530 - J Cell Biol. 1989 Nov;109(5):2323-35 8039934 - Infect Immun. 1994 Aug;62(8):3583-5 18555624 - Int J Pharm. 2008 Dec 8;364(2):272-80 6187729 - J Bacteriol. 1983 Apr;154(1):269-77 10627490 - Clin Microbiol Rev. 2000 Jan;13(1):35-54, table of contents 15322201 - J Immunol. 2004 Sep 1;173(5):3375-82 10782082 - Parasitol Today. 2000 May;16(5):213-7 17350765 - Vet Parasitol. 2007 May 15;146(1-2):182-8 18607005 - Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9361-6 3680997 - J Infect Dis. 1987 Dec;156(6):974-84 19696920 - PLoS Pathog. 2009 Aug;5(8):e1000560 17202369 - J Immunol. 2007 Jan 15;178(2):1059-67 20418884 - Nat Med. 2010 May;16(5):551-7, 1p following 557 16552082 - Infect Immun. 2006 Apr;74(4):2473-6 10486969 - Mol Biol Evol. 1999 Sep;16(9):1135-44 1528198 - Mol Cell Probes. 1992 Aug;6(4):271-9 18814692 - Parasite. 2008 Sep;15(3):261-5 11895935 - Infect Immun. 2002 Apr;70(4):1739-49 7974691 - Trans R Soc Trop Med Hyg. 1994 May-Jun;88(3):360-2 20605977 - Infect Immun. 2010 Sep;78(9):3969-80 18376145 - Hum Vaccin. 2008 Jan-Feb;4(1):13-22 19702359 - J Parasitol. 2009 Aug;95(4):895-9 11748158 - Infect Immun. 2002 Jan;70(1):11-8 18359106 - Mol Biochem Parasitol. 2008 Jun;159(2):85-91 6511706 - J Antimicrob Chemother. 1984 Nov;14(5):449-61 19079052 - Nature. 2008 Dec 11;456(7223):750-4 17888730 - Int J Med Microbiol. 2008 Jan;298(1-2):87-98 12792861 - J Infect Dis. 2003 Jun 15;187(12):1849-59 17846036 - Bioinformatics. 2007 Nov 1;23(21):2947-8 |
| References_xml | – volume: 19 start-page: 91 year: 1989 end-page: 98 ident: bib0150 article-title: Similarities of publication-title: Int J Parasitol – volume: 23 start-page: 2947 year: 2007 end-page: 2948 ident: bib0200 article-title: Clustal W and Clustal X version 2.0 publication-title: Bioinformatics – volume: 25 start-page: 8372 year: 2007 end-page: 8383 ident: bib0055 article-title: Mucosal delivery of a transmission-blocking DNA vaccine encoding publication-title: Vaccine – volume: 16 start-page: 213 year: 2000 end-page: 217 ident: bib0030 article-title: vaccination publication-title: Parasitol Today – volume: 71 start-page: 5662 year: 2003 end-page: 5669 ident: bib0045 article-title: Oral immunization of BALB/c mice with publication-title: Infect Immun – volume: 30 start-page: 255 year: 2010 end-page: 270 ident: bib0205 article-title: New technologies in using recombinant attenuated publication-title: Crit Rev Immunol – volume: 38 start-page: 691 year: 2008 end-page: 703 ident: bib0040 article-title: Characterization of the local immune response to cyst antigens during the acute and elimination phases of primary murine giardiasis publication-title: Int J Parasitol – volume: 156 start-page: 974 year: 1987 end-page: 984 ident: bib0015 article-title: Experimental human infections with publication-title: J Infect Dis – volume: 5 start-page: e1000560 year: 2009 ident: bib0095 article-title: Draft genome sequencing of giardia intestinalis assemblage B isolate GS: is human giardiasis caused by two different species? publication-title: PLoS Pathog – volume: 6 start-page: 79 year: 2004 end-page: 88 ident: bib0265 article-title: Enolase from Streptococcus sobrinus is an immunosuppressive protein publication-title: Cell Microbiol – volume: 183 start-page: 119 year: 2001 end-page: 124 ident: bib0070 article-title: Biological selection of variant-specific surface proteins in publication-title: J Infect Dis – volume: 16 start-page: 551 year: 2010 end-page: 557 ident: bib0085 article-title: Disruption of antigenic variation is crucial for effective parasite vaccine publication-title: Nat Med – volume: 62 start-page: 3583 year: 1994 end-page: 3585 ident: bib0140 article-title: infections in adult mice publication-title: Infect Immun – volume: 9 start-page: 1444 year: 2003 end-page: 1452 ident: bib0230 article-title: Triosephosphate isomerase gene characterization and potential zoonotic transmission of publication-title: Emerg Infect Dis – volume: 317 start-page: 1921 year: 2007 end-page: 1926 ident: bib0090 article-title: Genomic minimalism in the early diverging intestinal parasite publication-title: Science – volume: 33 start-page: 1341 year: 2003 end-page: 1351 ident: bib0260 article-title: Characterisation of alpha-1 giardin: an immunodominant publication-title: Int J Parasitol – volume: 68 start-page: 170 year: 2000 end-page: 175 ident: bib0215 article-title: T-cell-dependent control of acute publication-title: Infect Immun – volume: 173 start-page: 3375 year: 2004 end-page: 3382 ident: bib0290 article-title: A novel recombinant multisubunit vaccine against Chlamydia publication-title: J Immunol – volume: 177 start-page: 6281 year: 2006 end-page: 6290 ident: bib0110 article-title: Polymeric immunoglobulin receptor in intestinal immune defense against the lumen-dwelling protozoan parasite publication-title: J Immunol – volume: 78 start-page: 4251 year: 2010 end-page: 4260 ident: bib0180 article-title: Sublingual immunization protects against Helicobacter pylori infection and induces T and B cell responses in the stomach publication-title: Infect Immun – volume: 109 start-page: 2323 year: 1989 end-page: 2335 ident: bib0250 article-title: Ultrastructural localization of giardins to the edges of disk microribbons of Giarida lamblia and the nucleotide and deduced protein sequence of alpha giardin publication-title: J Cell Biol – volume: 10 start-page: 21 year: 1992 end-page: 27 ident: bib0220 article-title: Systemic-oral immunization with 56 kDa molecule of publication-title: Vaccine – volume: 364 start-page: 272 year: 2008 end-page: 280 ident: bib0125 article-title: Vaccine adjuvant systems: enhancing the efficacy of sub-unit protein antigens publication-title: Int J Pharm – volume: 456 start-page: 750 year: 2008 end-page: 754 ident: bib0080 article-title: Antigenic variation in publication-title: Nature – volume: 16 start-page: 1135 year: 1999 end-page: 1144 ident: bib0195 article-title: Molecular systematics of the parasitic protozoan publication-title: Mol Biol Evol – volume: 56 start-page: 316 year: 2007 end-page: 317 ident: bib0235 article-title: Mechanisms of epithelial dysfunction in giardiasis publication-title: Gut – volume: 187 start-page: 1849 year: 2003 end-page: 1859 ident: bib0100 article-title: Identification of immunoreactive proteins during acute human giardiasis publication-title: J Infect Dis – volume: 273 start-page: 14503 year: 1998 end-page: 14515 ident: bib0270 article-title: alpha-enolase, a novel strong plasmin(ogen) binding protein on the surface of pathogenic streptococci publication-title: J Biol Chem – volume: 70 start-page: 1739 year: 2002 end-page: 1749 ident: bib0165 article-title: Immune responses to recombinant pneumococcal PspA antigen delivered by live attenuated publication-title: Infect Immun – volume: 27 start-page: 965 year: 1997 end-page: 971 ident: bib0135 article-title: Systemic and local antibody response in mice induced by a recombinant peptide fragment from publication-title: Int J Parasitol – volume: 154 start-page: 269 year: 1983 end-page: 277 ident: bib0170 article-title: Morphological heterogeneity among publication-title: J Bacteriol – volume: 76 start-page: 5238 year: 2008 end-page: 5246 ident: bib0155 article-title: A sopB deletion mutation enhances the immunogenicity and protective efficacy of a heterologous antigen delivered by live attenuated publication-title: Infect Immun – volume: 95 start-page: 895 year: 2009 end-page: 899 ident: bib0255 article-title: Antibodies to the ventral disc protein delta-giardin prevent in vitro binding of publication-title: J Parasitol – volume: 6 start-page: 271 year: 1992 end-page: 279 ident: bib0190 article-title: Amplification of an invA gene sequence of publication-title: Mol Cell Probes – volume: 110 start-page: 1061 year: 2002 end-page: 1066 ident: bib0115 article-title: Bacterial infectious disease control by vaccine development publication-title: J Clin Invest – volume: 78 start-page: 3969 year: 2010 end-page: 3980 ident: bib0210 article-title: vaccine vectors displaying delayed antigen synthesis in vivo to enhance immunogenicity publication-title: Infect Immun – volume: 298 start-page: 87 year: 2008 end-page: 98 ident: bib0130 article-title: Rational design of publication-title: Int J Med Microbiol – volume: 42 start-page: 319 year: 2004 end-page: 324 ident: bib0280 article-title: Immunogenicity and protective effect of recombinant enolase of Candida albicans in a murine model of systemic candidiasis publication-title: Med Mycol – volume: 76 start-page: 3241 year: 2008 end-page: 3254 ident: bib0285 article-title: Analysis of type II secretion of recombinant pneumococcal PspA and PspC in a publication-title: Infect Immun – volume: 70 start-page: 11 year: 2002 end-page: 18 ident: bib0225 article-title: Central importance of immunoglobulin A in host defense against publication-title: Infect Immun – volume: 178 start-page: 1059 year: 2007 end-page: 1067 ident: bib0300 article-title: Oral vaccination with publication-title: J Immunol – volume: 35 start-page: 617 year: 2005 end-page: 626 ident: bib0245 article-title: Annexin-like alpha giardins: a new cytoskeletal gene family in publication-title: Int J Parasitol – volume: 11 start-page: 20 year: 2009 end-page: 28 ident: bib0050 article-title: Comparison of the local immune response against publication-title: Microbes Infect – volume: 88 start-page: 360 year: 1994 end-page: 362 ident: bib0010 article-title: Successful experimental infections of a human volunteer and Mongolian gerbils with publication-title: Trans R Soc Trop Med Hyg – volume: 27 start-page: 163 year: 2005 end-page: 169 ident: bib0105 article-title: Secretory antibodies against publication-title: Parasite Immunol – volume: 15 start-page: 261 year: 2008 end-page: 265 ident: bib0025 article-title: Pathophysiology of enteric infections with publication-title: Parasite – volume: 72 start-page: 4763 year: 2004 end-page: 4771 ident: bib0185 article-title: Experimental infections of neonatal mice with cysts of publication-title: Infect Immun – volume: 25 start-page: 55 year: 2003 end-page: 58 ident: bib0240 article-title: Prospect for an Entamoeba histolytica Gal-lectin-based vaccine publication-title: Parasite Immunol – volume: 146 start-page: 182 year: 2007 end-page: 188 ident: bib0035 article-title: Efficacy of vaccination in preventing giardiasis in calves publication-title: Vet Parasitol – volume: 105 start-page: 9361 year: 2008 end-page: 9366 ident: bib0295 article-title: Regulated programmed lysis of recombinant publication-title: Proc Natl Acad Sci USA – volume: 109 start-page: 1 year: 1992 end-page: 22 ident: bib0020 article-title: —diagnosis clinical course and epidemiology. A review publication-title: Epidemiol Infect – volume: 159 start-page: 85 year: 2008 end-page: 91 ident: bib0175 article-title: Release of metabolic enzymes by publication-title: Mol Biochem Parasitol – volume: 14 start-page: 449 year: 1984 end-page: 461 ident: bib0145 article-title: The sensitivity of publication-title: J Antimicrob Chemother – volume: 74 start-page: 2473 year: 2006 end-page: 2476 ident: bib0275 article-title: Adaptive immunity-dependent intestinal hypermotility contributes to host defense against publication-title: Infect Immun – volume: 45 start-page: 585 year: 2002 end-page: 590 ident: bib0065 article-title: Surface antigenic variation in publication-title: Mol Microbiol – volume: 13 start-page: 35 year: 2000 end-page: 54 ident: bib0060 article-title: Immune response to publication-title: Clin Microbiol Rev – volume: 4 start-page: 13 year: 2008 end-page: 22 ident: bib0120 article-title: Immune modulators with defined molecular targets: cornerstone to optimize rational vaccine design publication-title: Hum Vaccin – volume: 69 start-page: 5278 year: 2001 end-page: 5285 ident: bib0075 article-title: vsp gene expression by publication-title: Infect Immun – volume: 6 start-page: 693 year: 1988 end-page: 697 ident: bib0160 article-title: Construction of an Asd publication-title: Nat Biotechnol – volume: 5 start-page: 1 year: 2007 end-page: 38 ident: bib0005 article-title: Waterborne transmission of protozoan parasites: a worldwide review of outbreaks and lessons learnt publication-title: J Water Health – volume: 38 start-page: 691 year: 2008 ident: 10.1016/j.vaccine.2011.09.126_bib0040 article-title: Characterization of the local immune response to cyst antigens during the acute and elimination phases of primary murine giardiasis publication-title: Int J Parasitol doi: 10.1016/j.ijpara.2007.10.004 – volume: 154 start-page: 269 year: 1983 ident: 10.1016/j.vaccine.2011.09.126_bib0170 article-title: Morphological heterogeneity among Salmonella lipopolysaccharide chemotypes in silver-stained polyacrylamide gels publication-title: J Bacteriol doi: 10.1128/JB.154.1.269-277.1983 – volume: 273 start-page: 14503 year: 1998 ident: 10.1016/j.vaccine.2011.09.126_bib0270 article-title: alpha-enolase, a novel strong plasmin(ogen) binding protein on the surface of pathogenic streptococci publication-title: J Biol Chem doi: 10.1074/jbc.273.23.14503 – volume: 76 start-page: 5238 year: 2008 ident: 10.1016/j.vaccine.2011.09.126_bib0155 article-title: A sopB deletion mutation enhances the immunogenicity and protective efficacy of a heterologous antigen delivered by live attenuated Salmonella enterica vaccines publication-title: Infect Immun doi: 10.1128/IAI.00720-08 – volume: 15 start-page: 261 year: 2008 ident: 10.1016/j.vaccine.2011.09.126_bib0025 article-title: Pathophysiology of enteric infections with Giardia duodenalius publication-title: Parasite doi: 10.1051/parasite/2008153261 – volume: 6 start-page: 79 year: 2004 ident: 10.1016/j.vaccine.2011.09.126_bib0265 article-title: Enolase from Streptococcus sobrinus is an immunosuppressive protein publication-title: Cell Microbiol doi: 10.1046/j.1462-5822.2003.00344.x – volume: 62 start-page: 3583 year: 1994 ident: 10.1016/j.vaccine.2011.09.126_bib0140 article-title: Giardia lamblia infections in adult mice publication-title: Infect Immun doi: 10.1128/IAI.62.8.3583-3585.1994 – volume: 76 start-page: 3241 year: 2008 ident: 10.1016/j.vaccine.2011.09.126_bib0285 article-title: Analysis of type II secretion of recombinant pneumococcal PspA and PspC in a Salmonella enterica serovar Typhimurium vaccine with regulated delayed antigen synthesis publication-title: Infect Immun doi: 10.1128/IAI.01623-07 – volume: 95 start-page: 895 year: 2009 ident: 10.1016/j.vaccine.2011.09.126_bib0255 article-title: Antibodies to the ventral disc protein delta-giardin prevent in vitro binding of Giardia lamblia trophozoites publication-title: J Parasitol doi: 10.1645/GE-1851R.1 – volume: 33 start-page: 1341 year: 2003 ident: 10.1016/j.vaccine.2011.09.126_bib0260 article-title: Characterisation of alpha-1 giardin: an immunodominant Giardia lamblia annexin with glycosaminoglycan-binding activity publication-title: Int J Parasitol doi: 10.1016/S0020-7519(03)00201-7 – volume: 14 start-page: 449 year: 1984 ident: 10.1016/j.vaccine.2011.09.126_bib0145 article-title: The sensitivity of Giardia intestinalis to drugs in vitro publication-title: J Antimicrob Chemother doi: 10.1093/jac/14.5.449 – volume: 16 start-page: 551 year: 2010 ident: 10.1016/j.vaccine.2011.09.126_bib0085 article-title: Disruption of antigenic variation is crucial for effective parasite vaccine publication-title: Nat Med doi: 10.1038/nm.2141 – volume: 27 start-page: 163 year: 2005 ident: 10.1016/j.vaccine.2011.09.126_bib0105 article-title: Secretory antibodies against Giardia intestinalis in lactating Nicaraguan women publication-title: Parasite Immunol doi: 10.1111/j.1365-3024.2005.00758.x – volume: 187 start-page: 1849 year: 2003 ident: 10.1016/j.vaccine.2011.09.126_bib0100 article-title: Identification of immunoreactive proteins during acute human giardiasis publication-title: J Infect Dis doi: 10.1086/375356 – volume: 69 start-page: 5278 year: 2001 ident: 10.1016/j.vaccine.2011.09.126_bib0075 article-title: vsp gene expression by Giardia lamblia clone GS/M-83-H7 during antigenic variation in vivo and in vitro publication-title: Infect Immun doi: 10.1128/IAI.69.9.5278-5285.2001 – volume: 110 start-page: 1061 year: 2002 ident: 10.1016/j.vaccine.2011.09.126_bib0115 article-title: Bacterial infectious disease control by vaccine development publication-title: J Clin Invest doi: 10.1172/JCI0216941 – volume: 27 start-page: 965 year: 1997 ident: 10.1016/j.vaccine.2011.09.126_bib0135 article-title: Systemic and local antibody response in mice induced by a recombinant peptide fragment from Giardia lamblia variant surface protein (VSP) H7 produced by a Salmonella typhimurium vaccine strain publication-title: Int J Parasitol doi: 10.1016/S0020-7519(97)00064-7 – volume: 183 start-page: 119 year: 2001 ident: 10.1016/j.vaccine.2011.09.126_bib0070 article-title: Biological selection of variant-specific surface proteins in Giardia lamblia publication-title: J Infect Dis doi: 10.1086/317659 – volume: 35 start-page: 617 year: 2005 ident: 10.1016/j.vaccine.2011.09.126_bib0245 article-title: Annexin-like alpha giardins: a new cytoskeletal gene family in Giardia lamblia publication-title: Int J Parasitol doi: 10.1016/j.ijpara.2004.12.009 – volume: 72 start-page: 4763 year: 2004 ident: 10.1016/j.vaccine.2011.09.126_bib0185 article-title: Experimental infections of neonatal mice with cysts of Giardia lamblia clone GS/M-83-H7 are associated with an antigenic reset of the parasite publication-title: Infect Immun doi: 10.1128/IAI.72.8.4763-4771.2004 – volume: 109 start-page: 2323 year: 1989 ident: 10.1016/j.vaccine.2011.09.126_bib0250 article-title: Ultrastructural localization of giardins to the edges of disk microribbons of Giarida lamblia and the nucleotide and deduced protein sequence of alpha giardin publication-title: J Cell Biol doi: 10.1083/jcb.109.5.2323 – volume: 23 start-page: 2947 year: 2007 ident: 10.1016/j.vaccine.2011.09.126_bib0200 article-title: Clustal W and Clustal X version 2.0 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btm404 – volume: 16 start-page: 213 year: 2000 ident: 10.1016/j.vaccine.2011.09.126_bib0030 article-title: Giardia vaccination publication-title: Parasitol Today doi: 10.1016/S0169-4758(99)01623-3 – volume: 178 start-page: 1059 year: 2007 ident: 10.1016/j.vaccine.2011.09.126_bib0300 article-title: Oral vaccination with Salmonella simultaneously expressing Yersinia pestis F1 and V antigens protects against bubonic and pneumonic plague publication-title: J Immunol doi: 10.4049/jimmunol.178.2.1059 – volume: 71 start-page: 5662 year: 2003 ident: 10.1016/j.vaccine.2011.09.126_bib0045 article-title: Oral immunization of BALB/c mice with Giardia duodenalis recombinant cyst wall protein inhibits shedding of cysts publication-title: Infect Immun doi: 10.1128/IAI.71.10.5662-5669.2003 – volume: 5 start-page: e1000560 year: 2009 ident: 10.1016/j.vaccine.2011.09.126_bib0095 article-title: Draft genome sequencing of giardia intestinalis assemblage B isolate GS: is human giardiasis caused by two different species? publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1000560 – volume: 45 start-page: 585 year: 2002 ident: 10.1016/j.vaccine.2011.09.126_bib0065 article-title: Surface antigenic variation in Giardia lamblia publication-title: Mol Microbiol doi: 10.1046/j.1365-2958.2002.03029.x – volume: 146 start-page: 182 year: 2007 ident: 10.1016/j.vaccine.2011.09.126_bib0035 article-title: Efficacy of vaccination in preventing giardiasis in calves publication-title: Vet Parasitol doi: 10.1016/j.vetpar.2007.01.013 – volume: 68 start-page: 170 year: 2000 ident: 10.1016/j.vaccine.2011.09.126_bib0215 article-title: T-cell-dependent control of acute Giardia lamblia infections in mice publication-title: Infect Immun doi: 10.1128/IAI.68.1.170-175.2000 – volume: 159 start-page: 85 year: 2008 ident: 10.1016/j.vaccine.2011.09.126_bib0175 article-title: Release of metabolic enzymes by Giardia in response to interaction with intestinal epithelial cells publication-title: Mol Biochem Parasitol doi: 10.1016/j.molbiopara.2008.02.005 – volume: 42 start-page: 319 year: 2004 ident: 10.1016/j.vaccine.2011.09.126_bib0280 article-title: Immunogenicity and protective effect of recombinant enolase of Candida albicans in a murine model of systemic candidiasis publication-title: Med Mycol doi: 10.1080/13693780310001644653 – volume: 78 start-page: 3969 year: 2010 ident: 10.1016/j.vaccine.2011.09.126_bib0210 article-title: Salmonella vaccine vectors displaying delayed antigen synthesis in vivo to enhance immunogenicity publication-title: Infect Immun doi: 10.1128/IAI.00444-10 – volume: 9 start-page: 1444 year: 2003 ident: 10.1016/j.vaccine.2011.09.126_bib0230 article-title: Triosephosphate isomerase gene characterization and potential zoonotic transmission of Giardia duodenalis publication-title: Emerg Infect Dis doi: 10.3201/eid0911.030084 – volume: 13 start-page: 35 year: 2000 ident: 10.1016/j.vaccine.2011.09.126_bib0060 article-title: Immune response to Giardia duodenalis publication-title: Clin Microbiol Rev doi: 10.1128/CMR.13.1.35-54.2000 – volume: 16 start-page: 1135 year: 1999 ident: 10.1016/j.vaccine.2011.09.126_bib0195 article-title: Molecular systematics of the parasitic protozoan Giardia intestinalis publication-title: Mol Biol Evol doi: 10.1093/oxfordjournals.molbev.a026204 – volume: 6 start-page: 271 year: 1992 ident: 10.1016/j.vaccine.2011.09.126_bib0190 article-title: Amplification of an invA gene sequence of Salmonella typhimurium by polymerase chain reaction as a specific method of detection of Salmonella publication-title: Mol Cell Probes doi: 10.1016/0890-8508(92)90002-F – volume: 70 start-page: 11 year: 2002 ident: 10.1016/j.vaccine.2011.09.126_bib0225 article-title: Central importance of immunoglobulin A in host defense against Giardia spp publication-title: Infect Immun doi: 10.1128/IAI.70.1.11-18.2002 – volume: 11 start-page: 20 year: 2009 ident: 10.1016/j.vaccine.2011.09.126_bib0050 article-title: Comparison of the local immune response against Giardia lamblia cyst wall protein 2 induced by recombinant Lactococcus lactis and Streptococcus gordonii publication-title: Microbes Infect doi: 10.1016/j.micinf.2008.10.002 – volume: 364 start-page: 272 year: 2008 ident: 10.1016/j.vaccine.2011.09.126_bib0125 article-title: Vaccine adjuvant systems: enhancing the efficacy of sub-unit protein antigens publication-title: Int J Pharm doi: 10.1016/j.ijpharm.2008.04.036 – volume: 6 start-page: 693 year: 1988 ident: 10.1016/j.vaccine.2011.09.126_bib0160 article-title: Construction of an Asd+ expression-cloning vector: stable maintenance and high level expression of cloned genes in a Salmonella vaccine strain publication-title: Nat Biotechnol doi: 10.1038/nbt0688-693 – volume: 56 start-page: 316 year: 2007 ident: 10.1016/j.vaccine.2011.09.126_bib0235 article-title: Mechanisms of epithelial dysfunction in giardiasis publication-title: Gut doi: 10.1136/gut.2006.107771 – volume: 105 start-page: 9361 year: 2008 ident: 10.1016/j.vaccine.2011.09.126_bib0295 article-title: Regulated programmed lysis of recombinant Salmonella in host tissues to release protective antigens and confer biological containment publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0803801105 – volume: 298 start-page: 87 year: 2008 ident: 10.1016/j.vaccine.2011.09.126_bib0130 article-title: Rational design of Salmonella recombinant vaccines publication-title: Int J Med Microbiol doi: 10.1016/j.ijmm.2007.08.006 – volume: 317 start-page: 1921 year: 2007 ident: 10.1016/j.vaccine.2011.09.126_bib0090 article-title: Genomic minimalism in the early diverging intestinal parasite Giardia lamblia publication-title: Science doi: 10.1126/science.1143837 – volume: 88 start-page: 360 year: 1994 ident: 10.1016/j.vaccine.2011.09.126_bib0010 article-title: Successful experimental infections of a human volunteer and Mongolian gerbils with Giardia of animal origin publication-title: Trans R Soc Trop Med Hyg doi: 10.1016/0035-9203(94)90119-8 – volume: 4 start-page: 13 year: 2008 ident: 10.1016/j.vaccine.2011.09.126_bib0120 article-title: Immune modulators with defined molecular targets: cornerstone to optimize rational vaccine design publication-title: Hum Vaccin doi: 10.4161/hv.4.1.5560 – volume: 78 start-page: 4251 year: 2010 ident: 10.1016/j.vaccine.2011.09.126_bib0180 article-title: Sublingual immunization protects against Helicobacter pylori infection and induces T and B cell responses in the stomach publication-title: Infect Immun doi: 10.1128/IAI.00536-10 – volume: 70 start-page: 1739 year: 2002 ident: 10.1016/j.vaccine.2011.09.126_bib0165 article-title: Immune responses to recombinant pneumococcal PspA antigen delivered by live attenuated Salmonella enterica serovar typhimurium vaccine publication-title: Infect Immun doi: 10.1128/IAI.70.4.1739-1749.2002 – volume: 177 start-page: 6281 year: 2006 ident: 10.1016/j.vaccine.2011.09.126_bib0110 article-title: Polymeric immunoglobulin receptor in intestinal immune defense against the lumen-dwelling protozoan parasite Giardia publication-title: J Immunol doi: 10.4049/jimmunol.177.9.6281 – volume: 25 start-page: 55 year: 2003 ident: 10.1016/j.vaccine.2011.09.126_bib0240 article-title: Prospect for an Entamoeba histolytica Gal-lectin-based vaccine publication-title: Parasite Immunol doi: 10.1046/j.1365-3024.2003.00607.x – volume: 109 start-page: 1 year: 1992 ident: 10.1016/j.vaccine.2011.09.126_bib0020 article-title: Giardia—diagnosis clinical course and epidemiology. A review publication-title: Epidemiol Infect – volume: 156 start-page: 974 year: 1987 ident: 10.1016/j.vaccine.2011.09.126_bib0015 article-title: Experimental human infections with Giardia lamblia publication-title: J Infect Dis doi: 10.1093/infdis/156.6.974 – volume: 19 start-page: 91 year: 1989 ident: 10.1016/j.vaccine.2011.09.126_bib0150 article-title: Similarities of Giardia antigens derived from human and animal sources publication-title: Int J Parasitol doi: 10.1016/0020-7519(89)90026-X – volume: 456 start-page: 750 year: 2008 ident: 10.1016/j.vaccine.2011.09.126_bib0080 article-title: Antigenic variation in Giardia lamblia is regulated by RNA interference publication-title: Nature doi: 10.1038/nature07585 – volume: 30 start-page: 255 year: 2010 ident: 10.1016/j.vaccine.2011.09.126_bib0205 article-title: New technologies in using recombinant attenuated Salmonella vaccine vectors publication-title: Crit Rev Immunol doi: 10.1615/CritRevImmunol.v30.i3.30 – volume: 25 start-page: 8372 year: 2007 ident: 10.1016/j.vaccine.2011.09.126_bib0055 article-title: Mucosal delivery of a transmission-blocking DNA vaccine encoding Giardia lamblia CWP2 by Salmonella typhimurium bactofection vehicle publication-title: Vaccine doi: 10.1016/j.vaccine.2007.10.012 – volume: 5 start-page: 1 year: 2007 ident: 10.1016/j.vaccine.2011.09.126_bib0005 article-title: Waterborne transmission of protozoan parasites: a worldwide review of outbreaks and lessons learnt publication-title: J Water Health doi: 10.2166/wh.2006.002 – volume: 10 start-page: 21 year: 1992 ident: 10.1016/j.vaccine.2011.09.126_bib0220 article-title: Systemic-oral immunization with 56 kDa molecule of Giardia lamblia affords protection in experimental mice publication-title: Vaccine doi: 10.1016/0264-410X(92)90414-F – volume: 74 start-page: 2473 year: 2006 ident: 10.1016/j.vaccine.2011.09.126_bib0275 article-title: Adaptive immunity-dependent intestinal hypermotility contributes to host defense against Giardia spp publication-title: Infect Immun doi: 10.1128/IAI.74.4.2473-2476.2006 – volume: 173 start-page: 3375 year: 2004 ident: 10.1016/j.vaccine.2011.09.126_bib0290 article-title: A novel recombinant multisubunit vaccine against Chlamydia publication-title: J Immunol doi: 10.4049/jimmunol.173.5.3375 – reference: 20418884 - Nat Med. 2010 May;16(5):551-7, 1p following 557 – reference: 20605977 - Infect Immun. 2010 Sep;78(9):3969-80 – reference: 11087204 - J Infect Dis. 2001 Jan 1;183(1):119-24 – reference: 17996337 - Vaccine. 2007 Dec 5;25(50):8372-83 – reference: 18607005 - Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9361-6 – reference: 12791100 - Parasite Immunol. 2003 Feb;25(2):55-8 – reference: 12393839 - J Clin Invest. 2002 Oct;110(8):1061-6 – reference: 8039934 - Infect Immun. 1994 Aug;62(8):3583-5 – reference: 15271938 - Infect Immun. 2004 Aug;72(8):4763-71 – reference: 17202369 - J Immunol. 2007 Jan 15;178(2):1059-67 – reference: 10486969 - Mol Biol Evol. 1999 Sep;16(9):1135-44 – reference: 9292314 - Int J Parasitol. 1997 Aug;27(8):965-71 – reference: 18555624 - Int J Pharm. 2008 Dec 8;364(2):272-80 – reference: 6187729 - J Bacteriol. 1983 Apr;154(1):269-77 – reference: 9603964 - J Biol Chem. 1998 Jun 5;273(23):14503-15 – reference: 10627490 - Clin Microbiol Rev. 2000 Jan;13(1):35-54, table of contents – reference: 20696831 - Infect Immun. 2010 Oct;78(10):4251-60 – reference: 12792861 - J Infect Dis. 2003 Jun 15;187(12):1849-59 – reference: 18814692 - Parasite. 2008 Sep;15(3):261-5 – reference: 6511706 - J Antimicrob Chemother. 1984 Nov;14(5):449-61 – reference: 11500396 - Infect Immun. 2001 Sep;69(9):5278-85 – reference: 1528198 - Mol Cell Probes. 1992 Aug;6(4):271-9 – reference: 14718089 - Emerg Infect Dis. 2003 Nov;9(11):1444-52 – reference: 2651342 - Int J Parasitol. 1989 Feb;19(1):91-8 – reference: 15987339 - Parasite Immunol. 2005 May;27(5):163-9 – reference: 2808530 - J Cell Biol. 1989 Nov;109(5):2323-35 – reference: 1499664 - Epidemiol Infect. 1992 Aug;109(1):1-22 – reference: 14500486 - Infect Immun. 2003 Oct;71(10):5662-9 – reference: 15862575 - Int J Parasitol. 2005 May;35(6):617-26 – reference: 19079052 - Nature. 2008 Dec 11;456(7223):750-4 – reference: 17339241 - Gut. 2007 Mar;56(3):316-7 – reference: 10603384 - Infect Immun. 2000 Jan;68(1):170-5 – reference: 1539457 - Vaccine. 1992;10(1):21-7 – reference: 18992359 - Microbes Infect. 2009 Jan;11(1):20-8 – reference: 18359106 - Mol Biochem Parasitol. 2008 Jun;159(2):85-91 – reference: 17056558 - J Immunol. 2006 Nov 1;177(9):6281-90 – reference: 17901334 - Science. 2007 Sep 28;317(5846):1921-6 – reference: 18458067 - Infect Immun. 2008 Jul;76(7):3241-54 – reference: 11748158 - Infect Immun. 2002 Jan;70(1):11-8 – reference: 11895935 - Infect Immun. 2002 Apr;70(4):1739-49 – reference: 17402277 - J Water Health. 2007 Mar;5(1):1-38 – reference: 15473356 - Med Mycol. 2004 Aug;42(4):319-24 – reference: 7974691 - Trans R Soc Trop Med Hyg. 1994 May-Jun;88(3):360-2 – reference: 3680997 - J Infect Dis. 1987 Dec;156(6):974-84 – reference: 19696920 - PLoS Pathog. 2009 Aug;5(8):e1000560 – reference: 18376145 - Hum Vaccin. 2008 Jan-Feb;4(1):13-22 – reference: 17350765 - Vet Parasitol. 2007 May 15;146(1-2):182-8 – reference: 10782082 - Parasitol Today. 2000 May;16(5):213-7 – reference: 12139606 - Mol Microbiol. 2002 Aug;45(3):585-90 – reference: 15322201 - J Immunol. 2004 Sep 1;173(5):3375-82 – reference: 18765737 - Infect Immun. 2008 Nov;76(11):5238-46 – reference: 14678332 - Cell Microbiol. 2004 Jan;6(1):79-88 – reference: 20370633 - Crit Rev Immunol. 2010;30(3):255-70 – reference: 16552082 - Infect Immun. 2006 Apr;74(4):2473-6 – reference: 19702359 - J Parasitol. 2009 Aug;95(4):895-9 – reference: 18037419 - Int J Parasitol. 2008 May;38(6):691-703 – reference: 17888730 - Int J Med Microbiol. 2008 Jan;298(1-2):87-98 – reference: 14527517 - Int J Parasitol. 2003 Oct;33(12):1341-51 – reference: 17846036 - Bioinformatics. 2007 Nov 1;23(21):2947-8 |
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| Snippet | ► Giardia lamblia is a leading protozoan cause of diarrheal disease worldwide. ► Preventive medical strategies are not available against giardiasis. ►... Highlights ► Giardia lamblia is a leading protozoan cause of diarrheal disease worldwide. ► Preventive medical strategies are not available against giardiasis.... Giardia lamblia is a leading protozoan cause of diarrheal disease worldwide, yet preventive medical strategies are not available. A crude veterinary vaccine... Giardia lamblia is a leading protozoan cause of diarrheal disease worldwide, yet preventive medical strategies are not available. A crude veterinary vaccine... |
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| SubjectTerms | Administration, Oral Allergy and Immunology amino acid sequences Animal models Animals Antibodies, Protozoan - biosynthesis antigens Antigens, Protozoan - immunology Applied microbiology Biological and medical sciences blood serum cats cholera toxin Cholera Toxin - immunology cross reaction Cytoskeletal Proteins - administration & dosage Cytoskeletal Proteins - immunology dogs Fundamental and applied biological sciences. Psychology Giardia lamblia Giardia lamblia - immunology Giardiasis Giardiasis - immunology Giardiasis - prevention & control Human protozoal diseases humans immunization immunoglobulin A immunoglobulin G Infectious diseases Live oral vaccines Medical sciences Mice Mice, Inbred BALB C Microbiology oral administration ornithine Ornithine Carbamoyltransferase - administration & dosage Ornithine Carbamoyltransferase - immunology Parasitic diseases Parasitic diseases due to ciliates and flagellates phosphopyruvate hydratase Phosphopyruvate Hydratase - administration & dosage Phosphopyruvate Hydratase - immunology Protozoal diseases Protozoan Proteins - administration & dosage Protozoan Proteins - immunology Protozoan Vaccines - administration & dosage Protozoan Vaccines - immunology Salmonella Typhimurium Salmonella typhimurium - genetics vaccine development vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - immunology |
| Title | α1-giardin based live heterologous vaccine protects against Giardia lamblia infection in a murine model |
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