Subacute SARS-CoV-2 replication can be controlled in the absence of CD8+ T cells in cynomolgus macaques

• Published in: PLoS pathogens Vol. 17; no. 7; p. e1009668
• Main Authors: Nomura, Takushi, Yamamoto, Hiroyuki, Nishizawa, Masako, Hau, Trang Thi Thu, Harada, Shigeyoshi, Ishii, Hiroshi, Seki, Sayuri, Nakamura-Hoshi, Midori, Okazaki, Midori, Daigen, Sachie, Kawana-Tachikawa, Ai, Nagata, Noriyo, Iwata-Yoshikawa, Naoko, Shiwa, Nozomi, Iida, Shun, Katano, Harutaka, Suzuki, Tadaki, Park, Eun-Sil, Maeda, Ken, Suzaki, Yuriko, Ami, Yasushi, Matano, Tetsuro
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 19.07.2021; Public Library of Science (PLoS)
• Subjects: Analysis; Animals; Antibodies; Biology and life sciences; CD8 antigen; Coronaviruses; COVID-19; Disease transmission; Experiments; Infections; Lymph nodes; Lymphocytes; Lymphocytes T; Medicine and health sciences; Mucosa; Necropsy; Pharynx; Replication; Respiratory failure; Ribonucleic acid; RNA; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; T cells; Viral diseases; Viral infections; Viruses; Japan

SARS-CoV-2 infection presents clinical manifestations ranging from asymptomatic to fatal respiratory failure. Despite the induction of functional SARS-CoV-2-specific CD8 + T-cell responses in convalescent individuals, the role of virus-specific CD8 + T-cell responses in the control of SARS-CoV-2 rep...