4D nucleome equation predicts gene expression controlled by long-range enhancer-promoter interaction

• Published in: PLoS computational biology Vol. 19; no. 12; p. e1011722
• Main Authors: Wang, Zihao, Luo, Songhao, Zhang, Zhenquan, Zhou, Tianshou, Zhang, Jiajun
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.12.2023; Public Library of Science (PLoS)
• Subjects: Analysis; Animals; Biology and Life Sciences; Chromatin; Chromatin - genetics; Chromosomes; Decision making; Embryo cells; Embryonic stem cells; Enhancer Elements, Genetic - genetics; Gene Expression; Genes; Genetic aspects; Genetic transcription; Genomics; Heavy metals; Messenger RNA; Mice; Physical Sciences; Promoter Regions, Genetic - genetics; Promoters (Genetics); RNA, Messenger - genetics; Statistical analysis; Statistical inference; Stem cells; Transcription activation; Transcription initiation; China

Recent experimental evidence strongly supports that three-dimensional (3D) long-range enhancer-promoter (E-P) interactions have important influences on gene-expression dynamics, but it is unclear how the interaction information is translated into gene expression over time (4D). To address this quest...