Reovirus uses temporospatial compartmentalization to orchestrate core versus outercapsid assembly

• Published in: PLoS pathogens Vol. 18; no. 9; p. e1010641
• Main Authors: Kniert, Justine, dos Santos, Theodore, Eaton, Heather E, Jung Cho, Woo, Plummer, Greg, Shmulevitz, Maya
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 13.09.2022; Public Library of Science (PLoS)
• Subjects: Amplification; Assembly; Biology and Life Sciences; Capsids; Core particles; Cores; Cycloheximide; Development and progression; Double-stranded RNA; Electron microscopy; Factories; Fluorescence; Gene expression; Genetic aspects; Genomes; Infections; Lipids; Localization; Mammals; Medicine and Health Sciences; Microscopy; Nuclei (cytology); Pathogens; Prevention; Progeny; Proteins; Reoviruses; Replication; Research and Analysis Methods; Ribonucleic acid; RNA; RNA viruses; Rotavirus; siRNA; Virions; Viruses; Canada

Reoviridae virus family members, such as mammalian orthoreovirus (reovirus), encounter a unique challenge during replication. To hide the dsRNA from host recognition, the genome remains encapsidated in transcriptionally active proteinaceous core capsids that transcribe and release +RNA. De novo +RNA...