Efficacy of a novel in ovo-attenuated live vaccine and recombinant vaccine against a very virulent infectious bursal disease virus in chickens
Infectious bursal disease (IBD) causes severe economic damage to the poultry industry worldwide. To prevent IBD virus (IBDV) infection, live virus vaccines have been widely used in chickens having wide-ranging levels of maternally derived antibodies. But, the risks of infection with other pathogens...
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| Published in | Journal of Veterinary Medical Science Vol. 83; no. 11; pp. 1686 - 1693 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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Tokyo
JAPANESE SOCIETY OF VETERINARY SCIENCE
2021
Japan Science and Technology Agency The Japanese Society of Veterinary Science |
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| Abstract | Infectious bursal disease (IBD) causes severe economic damage to the poultry industry worldwide. To prevent IBD virus (IBDV) infection, live virus vaccines have been widely used in chickens having wide-ranging levels of maternally derived antibodies. But, the risks of infection with other pathogens because of lesions related to atrophy of the bursa of Fabricius in vaccinated chickens are a concern. To resolve the problems, a recombinant turkey herpesvirus (HVT) vaccine expressing IBDV-VP2 protein (rHVT-IBD) has been developed. However, the induction of neutralizing antibodies by rHVT-IBD against a virulent IBDV might be delayed compared with that by the live IBD vaccine, leading to the high risks of IBDV infection for young chickens. To find the best selection of IBDV vaccine for the onset of immunity, we examine the protective efficacy of a novel in ovo-attenuated live IBDV (IBD-CA) vaccine and the rHVT-IBD vaccine in young chickens challenged with a very virulent IBDV (vvIBDV) strain. We show that the protective efficacy of IBD-CA vaccine was higher than that of the rHVT-IBD vaccine in 14-day-old chickens challenged with the vvIBDV strain, leading to the risk of IBDV infection for young chickens when vaccinated with rHVT-IBD. Our results suggest that farmers should select the best vaccines to maximize vaccine efficacy in consideration of the vaccine characteristics, prevalence levels of IBDV in the areas, and initial MDA levels of the chickens since the attenuated live and recombinant vaccines play a role in the different vaccine efficacies. |
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| AbstractList | Infectious bursal disease (IBD) causes severe economic damage to the poultry industry worldwide. To prevent IBD virus (IBDV) infection, live virus vaccines have been widely used in chickens having wide-ranging levels of maternally derived antibodies. But, the risks of infection with other pathogens because of lesions related to atrophy of the bursa of Fabricius in vaccinated chickens are a concern. To resolve the problems, a recombinant turkey herpesvirus (HVT) vaccine expressing IBDV-VP2 protein (rHVT-IBD) has been developed. However, the induction of neutralizing antibodies by rHVT-IBD against a virulent IBDV might be delayed compared with that by the live IBD vaccine, leading to the high risks of IBDV infection for young chickens. To find the best selection of IBDV vaccine for the onset of immunity, we examine the protective efficacy of a novel in ovo-attenuated live IBDV (IBD-CA) vaccine and the rHVT-IBD vaccine in young chickens challenged with a very virulent IBDV (vvIBDV) strain. We show that the protective efficacy of IBD-CA vaccine was higher than that of the rHVT-IBD vaccine in 14-day-old chickens challenged with the vvIBDV strain, leading to the risk of IBDV infection for young chickens when vaccinated with rHVT-IBD. Our results suggest that farmers should select the best vaccines to maximize vaccine efficacy in consideration of the vaccine characteristics, prevalence levels of IBDV in the areas, and initial MDA levels of the chickens since the attenuated live and recombinant vaccines play a role in the different vaccine efficacies. Infectious bursal disease (IBD) causes severe economic damage to the poultry industry worldwide. To prevent IBD virus (IBDV) infection, live virus vaccines have been widely used in chickens having wide-ranging levels of maternally derived antibodies. But, the risks of infection with other pathogens because of lesions related to atrophy of the bursa of Fabricius in vaccinated chickens are a concern. To resolve the problems, a recombinant turkey herpesvirus (HVT) vaccine expressing IBDV-VP2 protein (rHVT-IBD) has been developed. However, the induction of neutralizing antibodies by rHVT-IBD against a virulent IBDV might be delayed compared with that by the live IBD vaccine, leading to the high risks of IBDV infection for young chickens. To find the best selection of IBDV vaccine for the onset of immunity, we examine the protective efficacy of a novel in ovo -attenuated live IBDV (IBD-CA) vaccine and the rHVT-IBD vaccine in young chickens challenged with a very virulent IBDV (vvIBDV) strain. We show that the protective efficacy of IBD-CA vaccine was higher than that of the rHVT-IBD vaccine in 14-day-old chickens challenged with the vvIBDV strain, leading to the risk of IBDV infection for young chickens when vaccinated with rHVT-IBD. Our results suggest that farmers should select the best vaccines to maximize vaccine efficacy in consideration of the vaccine characteristics, prevalence levels of IBDV in the areas, and initial MDA levels of the chickens since the attenuated live and recombinant vaccines play a role in the different vaccine efficacies. Infectious bursal disease (IBD) causes severe economic damage to the poultry industry worldwide. To prevent IBD virus (IBDV) infection, live virus vaccines have been widely used in chickens having wide-ranging levels of maternally derived antibodies. But, the risks of infection with other pathogens because of lesions related to atrophy of the bursa of Fabricius in vaccinated chickens are a concern. To resolve the problems, a recombinant turkey herpesvirus (HVT) vaccine expressing IBDV-VP2 protein (rHVT-IBD) has been developed. However, the induction of neutralizing antibodies by rHVT-IBD against a virulent IBDV might be delayed compared with that by the live IBD vaccine, leading to the high risks of IBDV infection for young chickens. To find the best selection of IBDV vaccine for the onset of immunity, we examine the protective efficacy of a novel in ovo-attenuated live IBDV (IBD-CA) vaccine and the rHVT-IBD vaccine in young chickens challenged with a very virulent IBDV (vvIBDV) strain. We show that the protective efficacy of IBD-CA vaccine was higher than that of the rHVT-IBD vaccine in 14-day-old chickens challenged with the vvIBDV strain, leading to the risk of IBDV infection for young chickens when vaccinated with rHVT-IBD. Our results suggest that farmers should select the best vaccines to maximize vaccine efficacy in consideration of the vaccine characteristics, prevalence levels of IBDV in the areas, and initial MDA levels of the chickens since the attenuated live and recombinant vaccines play a role in the different vaccine efficacies.Infectious bursal disease (IBD) causes severe economic damage to the poultry industry worldwide. To prevent IBD virus (IBDV) infection, live virus vaccines have been widely used in chickens having wide-ranging levels of maternally derived antibodies. But, the risks of infection with other pathogens because of lesions related to atrophy of the bursa of Fabricius in vaccinated chickens are a concern. To resolve the problems, a recombinant turkey herpesvirus (HVT) vaccine expressing IBDV-VP2 protein (rHVT-IBD) has been developed. However, the induction of neutralizing antibodies by rHVT-IBD against a virulent IBDV might be delayed compared with that by the live IBD vaccine, leading to the high risks of IBDV infection for young chickens. To find the best selection of IBDV vaccine for the onset of immunity, we examine the protective efficacy of a novel in ovo-attenuated live IBDV (IBD-CA) vaccine and the rHVT-IBD vaccine in young chickens challenged with a very virulent IBDV (vvIBDV) strain. We show that the protective efficacy of IBD-CA vaccine was higher than that of the rHVT-IBD vaccine in 14-day-old chickens challenged with the vvIBDV strain, leading to the risk of IBDV infection for young chickens when vaccinated with rHVT-IBD. Our results suggest that farmers should select the best vaccines to maximize vaccine efficacy in consideration of the vaccine characteristics, prevalence levels of IBDV in the areas, and initial MDA levels of the chickens since the attenuated live and recombinant vaccines play a role in the different vaccine efficacies. |
| ArticleNumber | 21-0319 |
| Author | TANENO, Akira OISHI, Eiji OTOMO, Hiroki SUZUKI, Shoko OKURA, Takashi ONO, Yuji |
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| Cites_doi | 10.3390/ani9030072 10.1556/EuJMI.4.2014.2.5 10.1128/jvi.31.3.584-589.1979 10.4142/jvs.2009.10.2.131 10.1371/journal.pone.0083210 10.2307/1591863 10.1046/j.1365-2567.2003.01744.x 10.1080/03079459108418779 10.1637/9507-081810-ResNote.1 10.1016/j.vaccine.2008.10.094 10.1080/03079457.2018.1520388 10.1016/j.vetmic.2003.08.005 10.1080/03079457.2016.1265083 10.1080/01652176.2004.9695170 10.1016/j.str.2005.04.012 10.1099/0022-1317-82-5-1107 10.1590/1806-9061-2015-0148 10.1637/11344-120815-Reg.1 10.1186/s12934-019-1061-9 10.1128/JVI.01501-07 |
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| Copyright | 2021 by the Japanese Society of Veterinary Science 2021. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2021 The Japanese Society of Veterinary Science 2021 |
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| References | 11. Müller, H., Scholtissek, C. and Becht, H. 1979. The genome of infectious bursal disease virus consists of two segments of double-stranded RNA. J. Virol. 31: 584–589. 4. Ingrao, F., Rauw, F., van den Berg, T. and Lambrecht, B. 2017. Characterization of two recombinant HVT-IBD vaccines by VP2 insert detection and cell-mediated immunity after vaccination of specific pathogen-free chickens. Avian Pathol. 46: 289–299. 3. Gelb, J. Jr., Jackwood, D. J., Brannick, E. M. and Ladman, B. S. 2016. Efficacy of recombinant HVT-IBD vaccines administered to broiler chicks from a single breeder flock at 30 and 60 weeks of age. Avian Dis. 60: 603–612. 10. Müller, H., Islam, M. R. and Raue, R. 2003. Research on infectious bursal disease—the past, the present and the future. Vet. Microbiol. 97: 153–165. 13. Olesen, L., Dijkman, R., Koopman, R., van Leeuwen, R., Gardin, Y., Dwars, R. M., de Bruijn, N. D., Boelm, G. J., Elattrache, J. and de Wit, J. J. 2018. Field and laboratory findings following the large-scale use of intermediate type infectious bursal disease vaccines in Denmark. Avian Pathol. 47: 595–606. 5. Jakka, P., Reddy, Y. K., Kirubaharan, J. J. and Chandran, N. D. 2014. Evaluation of immune responses by live infectious bursal disease vaccines to avoid vaccination failures. Eur. J. Microbiol. Immunol. (Bp.) 4: 123–127. 16. Saugar, I., Luque, D., Oña, A., Rodríguez, J. F., Carrascosa, J. L., Trus, B. L. and Castón, J. R. 2005. Structural polymorphism of the major capsid protein of a double-stranded RNA virus: an amphipathic alpha helix as a molecular switch. Structure 13: 1007–1017. 18. Taghavian, O., Spiegel, H., Hauck, R., Hafez, H. M., Fischer, R. and Schillberg, S. 2013. Protective oral vaccination against infectious bursal disease virus using the major viral antigenic protein VP2 produced in Pichia pastoris. PLoS One 8: e83210. 2. Camilotti, E., Moraes, L. B., Furian, T. Q., Borges, K. A., Moraes, H. L. S. and Salle, C. T. P. 2016. Infectious bursal disease: pathogenicity and immunogenicity of vaccine. Braz. J. Poultry Sci 18: 303–308. 9. Letzel, T., Coulibaly, F., Rey, F. A., Delmas, B., Jagt, E., van Loon, A. A. and Mundt, E. 2007. Molecular and structural bases for the antigenicity of VP2 of infectious bursal disease virus. J. Virol. 81: 12827–12835. 8. Lemiere, S., Wong, S. Y., Saint-Gerand, A. L., Goutebroze, S. and Le Gros, F. X. 2011. Compatibility of turkey herpesvirus-infectious bursal disease vector vaccine with Marek’s disease rispens vaccine injected into day-old pullets. Avian Dis. 55: 113–118. 14. Park, J. H., Sung, H. W., Yoon, B. I. and Kwon, H. M. 2009. Protection of chicken against very virulent IBDV provided by in ovo priming with DNA vaccine and boosting with killed vaccine and the adjuvant effects of plasmid-encoded chicken interleukin-2 and interferon-gamma. J. Vet. Sci. 10: 131–139. 17. Sedeik, M. E., El-Shall, N. A., Awad, A. M., Abd El-Hack, M. E., Alowaimer, A. N. and Swelum, A. A. 2019. Comparative evaluation of HVT-IBD vector, immune complex, and live IBD vaccines against vvIBDV in commercial broiler chickens with high maternally derived antibodies. Animals (Basel) 9: E72. 19. Tsukamoto, K., Tanimura, N., Kakita, S., Ota, K., Mase, M., Imai, K. and Hihara, H. 1995. Efficacy of three live vaccines against highly virulent infectious bursal disease virus in chickens with or without maternal antibodies. Avian Dis. 39: 218–229. 20. Wang, W., Song, Y., Liu, L., Zhang, Y., Wang, T., Zhang, W., Li, K., Qi, X., Gao, Y., Gao, L., Liu, C., Zhang, Y., Wang, Y., Pan, Q., He, G., Wang, X. and Cui, H. 2019. Neutralizing-antibody-mediated protection of chickens against infectious bursal disease via one-time vaccination with inactivated recombinant Lactococcus lactis expressing a fusion protein constructed from the RCK protein of Salmonella enterica and VP2 of infectious bursal disease virus. Microb. Cell Fact. 18: 21. 6. Jungmann, A., Nieper, H. and Müller, H. 2001. Apoptosis is induced by infectious bursal disease virus replication in productively infected cells as well as in antigen-negative cells in their vicinity. J. Gen. Virol. 82: 1107–1115. 12. Negash, T., al-Garib, S. O. and Gruys, E. 2004. Comparison of in ovo and post-hatch vaccination with particular reference to infectious bursal disease. A review. Vet. Q. 26: 76–87. 1. Berg, T. P. and Meulemans, G. 1991. Acute infectious bursal disease in poultry: protection afforded by maternally derived antibodies and interference with live vaccination. Avian Pathol. 20: 409–421. 7. Le Gros, F. X., Dancer, A., Giacomini, C., Pizzoni, L., Bublot, M., Graziani, M. and Prandini, F. 2009. Field efficacy trial of a novel HVT-IBD vector vaccine for 1-day-old broilers. Vaccine 27: 592–596. 15. Peters, M. A., Browning, G. F., Washington, E. A., Crabb, B. S. and Kaiser, P. 2003. Embryonic age influences the capacity for cytokine induction in chicken thymocytes. Immunology 110: 358–367. 11 12 13 14 15 16 17 18 19 1 2 3 4 5 6 7 8 9 20 10 |
| References_xml | – reference: 1. Berg, T. P. and Meulemans, G. 1991. Acute infectious bursal disease in poultry: protection afforded by maternally derived antibodies and interference with live vaccination. Avian Pathol. 20: 409–421. – reference: 10. Müller, H., Islam, M. R. and Raue, R. 2003. Research on infectious bursal disease—the past, the present and the future. Vet. Microbiol. 97: 153–165. – reference: 8. Lemiere, S., Wong, S. Y., Saint-Gerand, A. L., Goutebroze, S. and Le Gros, F. X. 2011. Compatibility of turkey herpesvirus-infectious bursal disease vector vaccine with Marek’s disease rispens vaccine injected into day-old pullets. Avian Dis. 55: 113–118. – reference: 11. Müller, H., Scholtissek, C. and Becht, H. 1979. The genome of infectious bursal disease virus consists of two segments of double-stranded RNA. J. Virol. 31: 584–589. – reference: 20. Wang, W., Song, Y., Liu, L., Zhang, Y., Wang, T., Zhang, W., Li, K., Qi, X., Gao, Y., Gao, L., Liu, C., Zhang, Y., Wang, Y., Pan, Q., He, G., Wang, X. and Cui, H. 2019. Neutralizing-antibody-mediated protection of chickens against infectious bursal disease via one-time vaccination with inactivated recombinant Lactococcus lactis expressing a fusion protein constructed from the RCK protein of Salmonella enterica and VP2 of infectious bursal disease virus. Microb. Cell Fact. 18: 21. – reference: 5. Jakka, P., Reddy, Y. K., Kirubaharan, J. J. and Chandran, N. D. 2014. Evaluation of immune responses by live infectious bursal disease vaccines to avoid vaccination failures. Eur. J. Microbiol. Immunol. (Bp.) 4: 123–127. – reference: 17. Sedeik, M. E., El-Shall, N. A., Awad, A. M., Abd El-Hack, M. E., Alowaimer, A. N. and Swelum, A. A. 2019. Comparative evaluation of HVT-IBD vector, immune complex, and live IBD vaccines against vvIBDV in commercial broiler chickens with high maternally derived antibodies. Animals (Basel) 9: E72. – reference: 2. Camilotti, E., Moraes, L. B., Furian, T. Q., Borges, K. A., Moraes, H. L. S. and Salle, C. T. P. 2016. Infectious bursal disease: pathogenicity and immunogenicity of vaccine. Braz. J. Poultry Sci 18: 303–308. – reference: 16. Saugar, I., Luque, D., Oña, A., Rodríguez, J. F., Carrascosa, J. L., Trus, B. L. and Castón, J. R. 2005. Structural polymorphism of the major capsid protein of a double-stranded RNA virus: an amphipathic alpha helix as a molecular switch. Structure 13: 1007–1017. – reference: 18. Taghavian, O., Spiegel, H., Hauck, R., Hafez, H. M., Fischer, R. and Schillberg, S. 2013. Protective oral vaccination against infectious bursal disease virus using the major viral antigenic protein VP2 produced in Pichia pastoris. PLoS One 8: e83210. – reference: 7. Le Gros, F. X., Dancer, A., Giacomini, C., Pizzoni, L., Bublot, M., Graziani, M. and Prandini, F. 2009. Field efficacy trial of a novel HVT-IBD vector vaccine for 1-day-old broilers. Vaccine 27: 592–596. – reference: 14. Park, J. H., Sung, H. W., Yoon, B. I. and Kwon, H. M. 2009. Protection of chicken against very virulent IBDV provided by in ovo priming with DNA vaccine and boosting with killed vaccine and the adjuvant effects of plasmid-encoded chicken interleukin-2 and interferon-gamma. J. Vet. Sci. 10: 131–139. – reference: 6. Jungmann, A., Nieper, H. and Müller, H. 2001. Apoptosis is induced by infectious bursal disease virus replication in productively infected cells as well as in antigen-negative cells in their vicinity. J. Gen. Virol. 82: 1107–1115. – reference: 9. Letzel, T., Coulibaly, F., Rey, F. A., Delmas, B., Jagt, E., van Loon, A. A. and Mundt, E. 2007. Molecular and structural bases for the antigenicity of VP2 of infectious bursal disease virus. J. Virol. 81: 12827–12835. – reference: 15. Peters, M. A., Browning, G. F., Washington, E. A., Crabb, B. S. and Kaiser, P. 2003. Embryonic age influences the capacity for cytokine induction in chicken thymocytes. Immunology 110: 358–367. – reference: 13. Olesen, L., Dijkman, R., Koopman, R., van Leeuwen, R., Gardin, Y., Dwars, R. M., de Bruijn, N. D., Boelm, G. J., Elattrache, J. and de Wit, J. J. 2018. Field and laboratory findings following the large-scale use of intermediate type infectious bursal disease vaccines in Denmark. Avian Pathol. 47: 595–606. – reference: 12. Negash, T., al-Garib, S. O. and Gruys, E. 2004. Comparison of in ovo and post-hatch vaccination with particular reference to infectious bursal disease. A review. Vet. Q. 26: 76–87. – reference: 3. Gelb, J. Jr., Jackwood, D. J., Brannick, E. M. and Ladman, B. S. 2016. Efficacy of recombinant HVT-IBD vaccines administered to broiler chicks from a single breeder flock at 30 and 60 weeks of age. Avian Dis. 60: 603–612. – reference: 4. Ingrao, F., Rauw, F., van den Berg, T. and Lambrecht, B. 2017. Characterization of two recombinant HVT-IBD vaccines by VP2 insert detection and cell-mediated immunity after vaccination of specific pathogen-free chickens. Avian Pathol. 46: 289–299. – reference: 19. Tsukamoto, K., Tanimura, N., Kakita, S., Ota, K., Mase, M., Imai, K. and Hihara, H. 1995. Efficacy of three live vaccines against highly virulent infectious bursal disease virus in chickens with or without maternal antibodies. Avian Dis. 39: 218–229. – ident: 17 doi: 10.3390/ani9030072 – ident: 5 doi: 10.1556/EuJMI.4.2014.2.5 – ident: 11 doi: 10.1128/jvi.31.3.584-589.1979 – ident: 14 doi: 10.4142/jvs.2009.10.2.131 – ident: 18 doi: 10.1371/journal.pone.0083210 – ident: 19 doi: 10.2307/1591863 – ident: 15 doi: 10.1046/j.1365-2567.2003.01744.x – ident: 1 doi: 10.1080/03079459108418779 – ident: 8 doi: 10.1637/9507-081810-ResNote.1 – ident: 7 doi: 10.1016/j.vaccine.2008.10.094 – ident: 13 doi: 10.1080/03079457.2018.1520388 – ident: 10 doi: 10.1016/j.vetmic.2003.08.005 – ident: 4 doi: 10.1080/03079457.2016.1265083 – ident: 12 doi: 10.1080/01652176.2004.9695170 – ident: 16 doi: 10.1016/j.str.2005.04.012 – ident: 6 doi: 10.1099/0022-1317-82-5-1107 – ident: 2 doi: 10.1590/1806-9061-2015-0148 – ident: 3 doi: 10.1637/11344-120815-Reg.1 – ident: 20 doi: 10.1186/s12934-019-1061-9 – ident: 9 doi: 10.1128/JVI.01501-07 |
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| Snippet | Infectious bursal disease (IBD) causes severe economic damage to the poultry industry worldwide. To prevent IBD virus (IBDV) infection, live virus vaccines... |
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| SubjectTerms | Antibodies Atrophy attenuated live infectious bursal disease virus vaccine Bursa of Fabricius in ovo inoculation Infections infectious bursal disease virus infectious bursal disease virus viral protein 2 expression Poultry recombinant turkey herpesvirus Vaccine efficacy Vaccines Virology Virulence Viruses VP2 protein |
| Title | Efficacy of a novel in ovo-attenuated live vaccine and recombinant vaccine against a very virulent infectious bursal disease virus in chickens |
| URI | https://www.jstage.jst.go.jp/article/jvms/83/11/83_21-0319/_article/-char/en https://www.proquest.com/docview/2591437613 https://www.proquest.com/docview/2573437910 https://pubmed.ncbi.nlm.nih.gov/PMC8636884 |
| Volume | 83 |
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| ispartofPNX | Journal of Veterinary Medical Science, 2021, Vol.83(11), pp.1686-1693 |
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