SERINC5 restricts influenza virus infectivity

• Published in: PLoS pathogens Vol. 18; no. 10; p. e1010907
• Main Authors: Zhao, Fei, Xu, Fengwen, Liu, Xiaoman, Hu, Yamei, Wei, Liang, Fan, Zhangling, Wang, Liming, Huang, Yu, Mei, Shan, Guo, Li, Yang, Long, Cen, Shan, Wang, Jianwei, Liang, Chen, Guo, Fei
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 12.10.2022; Public Library of Science (PLoS)
• Subjects: Amino acids; Anemia; Antiviral drugs; Biology and life sciences; Cell fusion; Cell membranes; Cloning; Computer and Information Sciences; Control; Distribution; Equine infectious anemia; Glycoproteins; Glycosylation; Health aspects; Hemagglutinins; HIV; Human immunodeficiency virus; Infections; Infectivity; Influenza; Influenza A; Influenza viruses; Leukemia; Medicine and health sciences; Membrane fusion; Membrane proteins; Protein expression; Proteins; Research and Analysis Methods; Sensitivity analysis; Stomatitis; Viral diseases; Viruses; China

SERINC5 is a multi-span transmembrane protein that is incorporated into HIV-1 particles in producing cells and inhibits HIV-1 entry. Multiple retroviruses like HIV-1, equine infectious anemia virus and murine leukemia virus are subject to SERINC5 inhibition, while HIV-1 pseudotyped with envelope gly...