Self-Reported Cognitive Function and Quality of Life in Patients With SCLC in the Hippocampal Avoidance Prophylactic Cranial Irradiation Versus Prophylactic Cranial Irradiation Randomized Phase 3 Trial (NCT01780675)

• Published in: JTO clinical and research reports Vol. 4; no. 5; p. 100506
• Main Authors: Albers, Elaine A.C., Zeng, Haiyan, De Ruysscher, Dirk K.M., Kuenen, Marianne A., Kessels, Rob, Hendriks, Lizza E.L., Belderbos, Jose S.A., Schagen, Sanne B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2023; Elsevier
• Subjects: Hematology, Oncology, and Palliative Medicine; Hippocampus; Original; PCI; Prophylactic cranial irradiation; Quality of life; SCLC; Self-reported cognitive functioning; SCLC; Prophylactic cranial irradiation; Hippocampus; PCI; Self-reported cognitive functioning; Quality of life

In the randomized controlled trial in patients with SCLC comparing standard prophylactic cranial irradiation (PCI) with hippocampal avoidance PCI (HA-PCI), we did not observe beneficial effects of HA-PCI on tested cognition. Here, we report findings on self-reported cognitive functioning (SRCF) and...