The support of human genetic evidence for approved drug indications

• Published in: Nature genetics Vol. 47; no. 8; pp. 856 - 860
• Main Authors: Nelson, Matthew R, Tipney, Hannah, Painter, Jeffery L, Shen, Judong, Nicoletti, Paola, Shen, Yufeng, Floratos, Aris, Sham, Pak Chung, Li, Mulin Jun, Wang, Junwen, Cardon, Lon R, Whittaker, John C, Sanseau, Philippe
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.08.2015; Nature Publishing Group
• Subjects: 631/154/1435; 631/208/205; Agriculture; analysis; Animal Genetics and Genomics; Biomedicine; Cancer Research; Chromosome Mapping; Databases, Genetic - statistics & numerical data; Drug Approval - statistics & numerical data; Drug interactions; Drug metabolism; Drugs; Gene Function; Genes; Genetic aspects; Genetic Association Studies - statistics & numerical data; Genetic Predisposition to Disease - genetics; Genetic research; Genetics; Genetics, Medical - methods; Genetics, Medical - statistics & numerical data; Genome-Wide Association Study - statistics & numerical data; Human Genetics; Humans; Innovations; Linkage Disequilibrium; Medical Subject Headings - utilization; Molecular targeted therapy; Molecular Targeted Therapy - statistics & numerical data; Pharmacology; Polymorphism, Single Nucleotide

Matthew Nelson and colleagues investigate how well genetic evidence for disease susceptibility predicts drug mechanisms. They find a correlation between gene products that are successful drug targets and genetic loci associated with the disease treated by the drug and predict that selecting genetica...