Identification of Envelope V3 Loop as the Major Determinant of CD4 Neutralization Sensitivity of HIV-1
Laboratory isolates of human immunodeficiency virus type-1 (HIV-1) such as HTLV-IIIB are generally T cell line-tropic and highly sensitive to neutralization by soluble CD4 (sCD4), a potential antiviral agent that is undergoing clinical trial. However, many primary HIV-1 isolates are macrophage-tropi...
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Published in | Science (American Association for the Advancement of Science) Vol. 257; no. 5069; pp. 535 - 537 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Washington, DC
American Society for the Advancement of Science
24.07.1992
American Association for the Advancement of Science |
Subjects | |
Online Access | Get full text |
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