Identification of Envelope V3 Loop as the Major Determinant of CD4 Neutralization Sensitivity of HIV-1

• Published in: Science (American Association for the Advancement of Science) Vol. 257; no. 5069; pp. 535 - 537
• Main Authors: Hwang, Stephen S., Boyle, Terence J., Lyerly, H. Kim, Cullen, Bryan R.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for the Advancement of Science 24.07.1992; American Association for the Advancement of Science
• Subjects: AIDS; AIDS/HIV; Amino Acid Sequence; Amino acids; Animals; Biological and medical sciences; CD4 Antigens - immunology; CD4 lymphocytes; Cell Line; Cells, Cultured; Dosage; Fundamental and applied biological sciences. Psychology; Gene Products, gag - immunology; HIV; HIV (Viruses); HIV 1; HIV Envelope Protein gp120 - immunology; HIV-1 - immunology; HIV-1 - isolation & purification; human immunodeficiency virus 1; Humans; Infections; Kinetics; Microbiology; Molecular Sequence Data; Neutralization Tests; Proviruses; Proviruses - immunology; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains; T lymphocytes; T-Lymphocyte Subsets - immunology; Transfection; Tropisms; Virion - immunology; Virions; Virology; Viruses; Virus; HIV-1 virus; Retroviridae; Lentivirinae; Glycoproteins; Human immunodeficiency virus; Soluble form; Virus envelope; Neutralization; Biological receptor

Laboratory isolates of human immunodeficiency virus type-1 (HIV-1) such as HTLV-IIIB are generally T cell line-tropic and highly sensitive to neutralization by soluble CD4 (sCD4), a potential antiviral agent that is undergoing clinical trial. However, many primary HIV-1 isolates are macrophage-tropi...