A novel heteromeric pantothenate kinase complex in apicomplexan parasites

• Published in: PLoS pathogens Vol. 17; no. 7; p. e1009797
• Main Authors: Tjhin, Erick T, Howieson, Vanessa M, Spry, Christina, van Dooren, Giel G, Saliba, Kevin J
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 29.07.2021; Public Library of Science (PLoS)
• Subjects: Analysis; Biology and Life Sciences; Chemical properties; Coenzyme A; Coenzymes; Enzyme kinetics; Experiments; Genomes; Homology; Kinases; Medicine and Health Sciences; Mutation; Organisms; Pantothenate kinase; Parasites; Peptides; Phosphorylation; Plasmodium falciparum; Proteins; Research and Analysis Methods; Toxoplasma; Australia

Coenzyme A is synthesised from pantothenate via five enzyme-mediated steps. The first step is catalysed by pantothenate kinase (PanK). All PanKs characterised to date form homodimers. Many organisms express multiple PanKs. In some cases, these PanKs are not functionally redundant, and some appear to...