Community and gene composition of a human dental plaque microbiota obtained by metagenomic sequencing

• Published in: Molecular oral microbiology Vol. 25; no. 6; pp. 391 - 405
• Main Authors: Xie, G., Chain, P.S.G., Lo, C.-C., Liu, K.-L., Gans, J., Merritt, J., Qi, F.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2010; Wiley
• Subjects: Actinobacteria - classification; Antibiotics; Bacteria - classification; Bacterial Proteins - genetics; Bacteroidetes - classification; Biological and medical sciences; Chromosome Mapping; Contig Mapping - methods; Cyanobacteria - classification; Databases, Nucleic Acid; Dental plaque; Dental Plaque - microbiology; Drug resistance; Drug Resistance, Bacterial - genetics; Ecosystem; Fibrobacter - classification; fragment recruitment; Fundamental and applied biological sciences. Psychology; Fusobacteria - classification; Gastrointestinal Tract - microbiology; Gene mapping; Genome, Bacterial - genetics; genomics; human oral microbiome; Humans; Metagenome - genetics; metagenomic sequencing; Metagenomics - methods; Microbiology; next generation sequencing; Oral cavity; Oral diseases; oralgen; Pathogens; Plaques; Proteobacteria - classification; RNA, Bacterial - genetics; RNA, Ribosomal, 16S - genetics; Sequence Analysis, DNA; Species richness; Spirochaetaceae - classification; Human; metagenomic sequencing; Stomatology; next generation sequencing; Dental disease; oralgen; Dental plaque; Microflora; Immunology; Gene; human oral microbiome; fragment recruitment; Metagenome; Microbiome

Summary Human dental plaque is a complex microbial community containing an estimated 700 to 19,000 species/phylotypes. Despite numerous studies analysing species richness in healthy and diseased human subjects, the true genomic composition of the human dental plaque microbiota remains unknown. Here...