Pediatric Inflammatory Bowel Diseases and the Risk of Lymphoma: Should We Revise Our Treatment Strategies?

• Published in: Journal of pediatric gastroenterology and nutrition Vol. 48; no. 3; pp. 257 - 267
• Main Authors: Cucchiara, Salvatore, Escher, Johanna C, Hildebrand, Hans, Amil‐Dias, Jorge, Stronati, Laura, Ruemmele, Frank M
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins, Inc 01.03.2009; Lippincott Williams & Wilkins
• Subjects: Anti‐TNF; Biological and medical sciences; Biological Products - adverse effects; Biological Products - therapeutic use; Biologicals; Child; Crohn; Drug Therapy, Combination; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; Gastroenterology. Liver. Pancreas. Abdomen; Hematologic and hematopoietic diseases; Humans; Immunosuppression - adverse effects; Immunosuppressive Agents - adverse effects; Immunosuppressive Agents - therapeutic use; Inflammatory bowel disease; Inflammatory Bowel Diseases - complications; Inflammatory Bowel Diseases - drug therapy; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoma; Lymphoma, T-Cell - epidemiology; Lymphoma, T-Cell - etiology; Medical sciences; Medicin och hälsovetenskap; Other diseases. Semiology; Pediatric; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumor Necrosis Factor-alpha - antagonists & inhibitors; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Human; Pediatrics; Anti-TNF; Metabolic diseases; Malignant hemopathy; Lymphoma; Inflammatory disease; Crohn disease; Anti- TNF-Biologicals-Crohn-Inflammatory bowel disease- Lymphoma-Pediatric; Treatment; Lymphoproliferative syndrome; Risk factor; Gastroenterology; Digestive diseases; Intestinal disease; Child; Cancer; Ulcerative colitis

ABSTRACT Inflammatory bowel diseases (IBDs) are lifelong inflammatory gastrointestinal diseases starting in about one third of patients during childhood. Treatment strategies aim to control this chronic inflammatory process. Owing to recent advances in the understanding of IBD, immunosuppressive age...