Eicosapentaenoic acid free fatty acid prevents and suppresses colonic neoplasia in colitis‐associated colorectal cancer acting on Notch signaling and gut microbiota

• Published in: International journal of cancer Vol. 135; no. 9; pp. 2004 - 2013
• Main Authors: Piazzi, Giulia, D'Argenio, Giuseppe, Prossomariti, Anna, Lembo, Vincenzo, Mazzone, Giovanna, Candela, Marco, Biagi, Elena, Brigidi, Patrizia, Vitaglione, Paola, Fogliano, Vincenzo, D'Angelo, Leonarda, Fazio, Chiara, Munarini, Alessandra, Belluzzi, Andrea, Ceccarelli, Claudio, Chieco, Pasquale, Balbi, Tiziana, Loadman, Paul M., Hull, Mark A., Romano, Marco, Bazzoli, Franco, Ricciardiello, Luigi
• Format: Journal Article
• Language: English
• Published: Hoboken, NJ Wiley-Blackwell 01.11.2014; Wiley Subscription Services, Inc
• Subjects: Animals; Apoptosis; Biological and medical sciences; Cancer; Cell Proliferation; cells; chemoprevention; Colitis - chemically induced; Colitis - complications; Colitis - pathology; Colon - microbiology; Colon - pathology; colon cancer; Colorectal cancer; Colorectal Neoplasms - etiology; Colorectal Neoplasms - pathology; Colorectal Neoplasms - prevention & control; dietary fish-oil; differentiation; docosahexaenoic acid; Eicosapentaenoic Acid - administration & dosage; Fatty acids; Fatty Acids, Nonesterified - administration & dosage; Gastroenterology. Liver. Pancreas. Abdomen; Gastrointestinal Tract - drug effects; Gastrointestinal Tract - metabolism; Gastrointestinal Tract - microbiology; Immunoenzyme Techniques; inflammation; Inflammation - etiology; Inflammation - pathology; Inflammation - prevention & control; Inflammatory bowel disease; intestinal microbiota; Lactobacillus; Male; Medical research; Medical sciences; Mice; Mice, Inbred C57BL; microbiota; Microbiota - drug effects; Microbiota - physiology; mouse model; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Notch; omega 3; Real-Time Polymerase Chain Reaction; Receptors, Notch - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; Rodents; sodium; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; microbiota; Notch receptor; Rectal disease; Digestive system; Colorectal cancer; Gut; Notch; omega 3; Lipids; Inflammation; Free fatty acid; Malignant tumor; n-3 fatty acid; Colonic disease; Prevention; Signal transduction; Colon cancer; Cancerology; Digestive diseases; Intestinal disease; Colitis; Colon; Eicosapentaenoic acid; Cancer; inflammation; colon cancer

Inflammatory bowel diseases are associated with increased risk of developing colitis‐associated colorectal cancer (CAC). Epidemiological data show that the consumption of ω‐3 polyunsaturated fatty acids (ω‐3 PUFAs) decreases the risk of sporadic colorectal cancer (CRC). Importantly, recent data have...