Eicosapentaenoic acid free fatty acid prevents and suppresses colonic neoplasia in colitis‐associated colorectal cancer acting on Notch signaling and gut microbiota - Piazzi, Giulia; D'Argenio, Giuseppe; Prossomariti, Anna; Lembo, Vincenzo; Mazzone, Giovanna; Candela, Marco; Biagi, Elena; Brigidi, Patrizia; Vitaglione, Paola; Fogliano, Vincenzo; D'Angelo, Leonarda; Fazio, Chiara; et al. (International journal of cancer, 2014)
Keywords: Animals; Apoptosis; Biological and medical sciences; Cancer; Cell Proliferation; cells; chemoprevention; Colitis - chemically induced; Colitis - complications; Colitis - pathology; Colon - microbiology; Colon - pathology; colon cancer; Colorectal cancer; Colorectal Neoplasms - etiology; Colorectal Neoplasms - pathology; Colorectal Neoplasms - prevention & control; dietary fish-oil; differentiation; docosahexaenoic acid; Eicosapentaenoic Acid - administration & dosage; Fatty acids; Fatty Acids, Nonesterified - administration & dosage; Gastroenterology. Liver. Pancreas. Abdomen; Gastrointestinal Tract - drug effects; Gastrointestinal Tract - metabolism; Gastrointestinal Tract - microbiology; Immunoenzyme Techniques; inflammation; Inflammation - etiology; Inflammation - pathology; Inflammation - prevention & control; Inflammatory bowel disease; intestinal microbiota; Lactobacillus; Male; Medical research; Medical sciences; Mice; Mice, Inbred C57BL; microbiota; Microbiota - drug effects; Microbiota - physiology; mouse model; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Notch; omega 3; Real-Time Polymerase Chain Reaction; Receptors, Notch - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; Rodents; sodium; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; microbiota; Notch receptor; Rectal disease; Digestive system; Colorectal cancer; Gut; Notch; omega 3; Lipids; Inflammation; Free fatty acid; Malignant tumor; n-3 fatty acid; Colonic disease; Prevention; Signal transduction; Colon cancer; Cancerology; Digestive diseases; Intestinal disease; Colitis; Colon; Eicosapentaenoic acid; Cancer; inflammation; colon cancer