452-P: Liraglutide Decreases Neointimal Growth in Control and Western Diet–Fed Mice, and Its Effect Is Insulin Dependent

• Published in: Diabetes (New York, N.Y.) Vol. 71; no. Supplement_1
• Main Authors: GONZALEZ, MAREL, LIU, ZHIWEI, GIACCA, ADRIA
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 01.06.2022
• Subjects: Angioplasty; Antidiabetics; Cardiovascular diseases; Cre recombinase; Diabetes; Diabetes mellitus (insulin dependent); Diabetes mellitus (non-insulin dependent); Endothelial cells; Femoral artery; GLP-1 receptor agonists; Glucagon; Glucagon-like peptide 1; High fat diet; Insulin; Insulin resistance; Low fat diet; Restenosis; Sucrose
• ISSN: 0012-1797; 1939-327X
• DOI: 10.2337/db22-452-P

Restenosis following percutaneous transluminal angioplasty and stenting is increased in subjects with insulin resistance and diabetes. Our preclinical models of restenosis show that insulin treatment is vasculoprotective in insulin sensitive conditions but insulin's effect is diminished or lost...