Biosynthesis of nervonic acid and perspectives for its production by microalgae and other microorganisms

• Published in: Applied microbiology and biotechnology Vol. 102; no. 7; pp. 3027 - 3035
• Main Authors: Fan, Yong, Meng, Hui-Min, Hu, Guang-Rong, Li, Fu-Li
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2018; Springer; Springer Nature B.V
• Subjects: Algae; Aquatic microorganisms; Biomedical and Life Sciences; Biosynthesis; Biotechnology; Chains; Elongation; Fatty acids; Fungi; Gene expression; genes; heterologous gene expression; Life Sciences; malonyl coenzyme A; mammals; Mental disorders; Metabolism; Methods; Microalgae; Microbial Genetics and Genomics; Microbiology; Microorganisms; Mini-Review; nervonic acid; neurodevelopment; Neurological diseases; Oleic acid; Physiological aspects; plants (botany); Psychosis; Substantia alba; Yeast; yeasts; Metabolic engineering; Synthetic biology; Very long-chain monounsaturated fatty acids; Cellular engineering; 3-Ketoacyl-CoA synthesis

Nervonic acid (NA) is a major very long-chain monounsaturated fatty acid found in the white matter of mammalian brains, which plays a critical role in the treatment of psychotic disorders and neurological development. In the nature, NA has been synthesized by a handful plants, fungi, and microalgae....