The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis

• Published in: Journal of hematology and oncology Vol. 15; no. 1; pp. 1 - 129
• Main Authors: Huang, Yuhe, Hong, Weiqi, Wei, Xiawei
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 08.09.2022; BioMed Central; BMC
• Subjects: Analysis; Antisense RNA; Cancer; Cell adhesion & migration; Chemotherapy; Circulating tumor cells; Cytoskeleton; Development and progression; Embryogenesis; Epigenetic inheritance; Epigenetics; Epithelial–mesenchymal transition; Gene expression; Genetic transcription; Health aspects; Hematology; Immunotherapy; Invasiveness; Mesenchyme; Metastases; Metastasis; Molecular modelling; Morphogenesis; Oncology; Post-translation; Review; Stem cells; Tissue engineering; Transcription factors; Tumor cells; Tumor stemness; Tumorigenesis; Wound healing

Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic development and tissue regeneration. However, aberrant reactivation of EMT is associated with malignant properties of tumor cells during cancer progression and metastasis, including promoted migration and invasivenes...