Dexamethasone for Dyspnea in Cancer Patients: A Pilot Double-Blind, Randomized, Controlled Trial

• Published in: Journal of pain and symptom management Vol. 52; no. 1; pp. 8 - 16.e1
• Main Authors: Hui, David, MD, MSc, Kilgore, Kelly, BS, Frisbee-Hume, Susan, MS, Park, Minjeong, PhD, Tsao, Anne, MD, Delgado Guay, Marvin, MD, Lu, Charles, MD, William, William, MD, Pisters, Katherine, MD, Eapen, George, MD, Fossella, Frank, MD, Amin, Sapna, PharmD, Bruera, Eduardo, MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2016
• Subjects: Aged; Anesthesia & Perioperative Care; Anti-Inflammatory Agents - therapeutic use; Dexamethasone; Dexamethasone - therapeutic use; Double-Blind Method; dyspnea; Dyspnea - complications; Dyspnea - drug therapy; Feasibility Studies; Female; Humans; Male; Middle Aged; neoplasms; Neoplasms - complications; Neoplasms - drug therapy; Pain Medicine; pharmacologic therapy; Pilot Projects; pilot study; Quality of Life; randomized controlled trial; Severity of Illness Index; Sleep Stages - drug effects; Spirometry; Treatment Outcome; United States > US; dexamethasone; pharmacologic therapy; pilot study; dyspnea; neoplasms; quality of life; randomized controlled trial; Dexamethasone

Abstract Context Dexamethasone is often used to treat dyspnea in cancer patients but evidence is lacking. Objectives We determined the feasibility of conducting a randomized trial of dexamethasone in cancer patients, and estimated the efficacy of dexamethasone in the treatment of dyspnea. Methods In...