Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 151; no. 4; pp. 733 - 746.e12
• Main Authors: Rahman, Khalidur, Desai, Chirayu, Iyer, Smita S., Thorn, Natalie E., Kumar, Pradeep, Liu, Yunshan, Smith, Tekla, Neish, Andrew S., Li, Hongliang, Tan, Shiyun, Wu, Pengbo, Liu, Xiaoxiong, Yu, Yuanjie, Farris, Alton B., Nusrat, Asma, Parkos, Charles A., Anania, Frank A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2016
• Subjects: Animals; Bacterial Translocation; Cell Adhesion Molecules - deficiency; Cholesterol; Claudin-4; Diet, High-Fat - adverse effects; Diet, High-Fat - methods; Dietary Carbohydrates; Disease Models, Animal; Dysbiosis - complications; Dysbiosis - genetics; Fructose; Gastroenterology and Hepatology; Gastrointestinal Microbiome - genetics; Intestinal Mucosa - metabolism; Intestinal Mucosa - microbiology; Liver - pathology; Male; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease - genetics; Non-alcoholic Fatty Liver Disease - microbiology; Non-alcoholic Fatty Liver Disease - pathology; Occludin; Permeability; Receptors, Cell Surface - deficiency; Reverse Transcriptase Polymerase Chain Reaction; AST; NAFLD; IL; rRNA; ALT; NASH; Bacterial Translocation; Claudin-4; LPS; Occludin; FITC; MetS; TJ; αSMA; HSC; JAM-A; TLR; NAFL; CRN; HFCD; PCR; alanine aminotransferase; Clinical Research Network; nonalcoholic steatohepatitis; high-fat, high-fructose, and high-cholesterol diet; ribosomal RNA; hepatic stellate cell; interleukin; fluorescein isothiocyanate; polymerase chain reaction; tight junction; Toll-like receptor; nonalcoholic fatty liver; junctional adhesion molecule A; aspartate aminotransferase; α smooth muscle actin; metabolic syndrome; nonalcoholic fatty liver disease; lipopolysaccharide

There is evidence from clinical studies that compromised intestinal epithelial permeability contributes to the development of nonalcoholic steatohepatitis (NASH), but the exact mechanisms are not clear. Mice with disruption of the gene (F11r) encoding junctional adhesion molecule A (JAM-A) have defe...