Profiles of Cancer Stem Cell Subpopulations in Cholangiocarcinomas

• Published in: The American journal of pathology Vol. 185; no. 6; pp. 1724 - 1739
• Main Authors: Cardinale, Vincenzo, Renzi, Anastasia, Carpino, Guido, Torrice, Alessia, Bragazzi, Maria C., Giuliante, Felice, De Rose, Agostino M., Fraveto, Alice, Onori, Paolo, Napoletano, Chiara, Franchitto, Antonio, Cantafora, Alfredo, Grazi, GianLuca, Caporaso, Nicola, D'Argenio, Giuseppe, Alpini, Gianfranco, Reid, Lola M., Gaudio, Eugenio, Alvaro, Domenico
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2015; American Society for Investigative Pathology
• Subjects: Aged; Aged, 80 and over; Animals; Bile Duct Neoplasms - metabolism; Bile Duct Neoplasms - pathology; Biomarkers, Tumor - metabolism; Cell Line, Tumor; Cholangiocarcinoma - metabolism; Cholangiocarcinoma - pathology; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Humans; Liver - metabolism; Liver - pathology; Male; Mice; Middle Aged; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - pathology; Pathology; Regular; Transplantation, Heterologous

Cholangiocarcinomas (CCAs) comprise a mucin-secreting form, intrahepatic or perihilar, and a mixed form located peripherally. We characterized cancer stem cells (CSCs) in CCA subtypes and evaluated their cancerogenic potential. CSC markers were investigated in 25 human CCAs in primary cultures and e...