Iron regulation by hepcidin

• Published in: The Journal of clinical investigation Vol. 123; no. 6; pp. 2337 - 2343
• Main Authors: Zhao, Ningning, Zhang, An-Sheng, Enns, Caroline A.
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.06.2013
• Subjects: Animals; Antimicrobial Cationic Peptides - genetics; Antimicrobial Cationic Peptides - metabolism; beta-Thalassemia - blood; beta-Thalassemia - genetics; Biomedical research; Bone Morphogenetic Proteins - metabolism; Cell Hypoxia; Chronic Disease; Control; Gene Expression Regulation; GPI-Linked Proteins - metabolism; Hematopoiesis; Hepcidins; Homeostasis; Humans; Identification and classification; Iron - metabolism; Iron in the body; Kinases; Matrix Metalloproteinase 15 - metabolism; Mutation; Peptide hormones; Physiological aspects; Properties; Proteins; Receptors, Transferrin - metabolism; Rodents; Science in Medicine; Signal Transduction

Hepcidin is a key hormone that is involved in the control of iron homeostasis in the body. Physiologically, hepcidin is controlled by iron stores, inflammation, hypoxia, and erythropoiesis. The regulation of hepcidin expression by iron is a complex process that requires the coordination of multiple...