Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities

• Published in: Molecular psychiatry Vol. 26; no. 6; pp. 1808 - 1831
• Main Authors: Ikezu, Seiko, Yeh, Hana, Delpech, Jean-Christophe, Woodbury, Maya E., Van Enoo, Alicia A., Ruan, Zhi, Sivakumaran, Sudhir, You, Yang, Holland, Carl, Guillamon-Vivancos, Teresa, Yoshii-Kitahara, Asuka, Botros, Mina B., Madore, Charlotte, Chao, Pin-Hao, Desani, Ankita, Manimaran, Solaiappan, Kalavai, Srinidhi Venkatesan, Johnson, W. Evan, Butovsky, Oleg, Medalla, Maria, Luebke, Jennifer I., Ikezu, Tsuneya
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2021; Nature Publishing Group
• Subjects: 13/1; 13/106; 13/51; 14/19; 14/32; 14/63; 14/69; 38/91; 631/337; 631/378; 64/60; 692/699/476/1373; 96/31; Animals; Axonogenesis; Behavior, Animal; Behavioral Sciences; Biological Psychology; Brain; Cell receptors; Child development deviations; Colonies; Colony-stimulating factor; Colony-stimulating factors (Physiology); Complications and side effects; Dendritic spines; Development and progression; Developmental disabilities; Disease Models, Animal; Female; Fetus; Gene expression; Growth; Health aspects; Immune response; Immune system; Inflammation; Innate immunity; Life Sciences; Macrophage Colony-Stimulating Factor; Medicine; Medicine & Public Health; Mental illness; Mice; Microglia; Neurons; Neurons and Cognition; Neurosciences; Perinatal infection; Pharmacotherapy; Phenotypes; Physiological aspects; Prefrontal cortex; Pregnancy; Prenatal Exposure Delayed Effects; Prenatal influences; Psychiatry; Pyramidal cells; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Risk factors; Social behavior; United States

Maternal immune activation (MIA) disrupts the central innate immune system during a critical neurodevelopmental period. Microglia are primary innate immune cells in the brain although their direct influence on the MIA phenotype is largely unknown. Here we show that MIA alters microglial gene express...