Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly

The role of the mitochondria in disease, general health and aging has drawn much attention over the years. Several attempts have been made to describe how the numbers of mitochondria correlate with age, although with inconclusive results. In this study, the relative quantity of mitochondrial DNA com...

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Bibliographic Details
Published inHuman genetics Vol. 133; no. 9; pp. 1149 - 1159
Main Authors Mengel-From, Jonas, Thinggaard, Mikael, Dalgård, Christine, Kyvik, Kirsten Ohm, Christensen, Kaare, Christiansen, Lene
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2014
Springer
Springer Nature B.V
Subjects
Adolescent
Adult
Age
Age Factors
Aged
Aged, 80 and over
Aging
Aging - genetics
Analysis
Biomarkers
Biomedical and Life Sciences
Biomedicine
Blood
Body Mass Index
Cross-Sectional Studies
Denmark
DNA Copy Number Variations
DNA, Mitochondrial - blood
DNA, Mitochondrial - genetics
Female
Gene Function
Genetic research
Genomes
Health aspects
Hospitals
Human Genetics
Humans
Leukocytes
Longitudinal Studies
Lung cancer
Male
Metabolic Diseases
Middle Aged
Mitochondria
Mitochondrial DNA
Molecular Medicine
Mortality
Mutation
Original Investigation
Oxidative stress
Public health
Self Report
Twins
Young Adult
Denmark
Birth Cohort
Cognitive Composite Score
Twin Pair
Danish Twin
POLG Gene
Online AccessGet full text
ISSN0340-6717
1432-1203
1432-1203
DOI10.1007/s00439-014-1458-9

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Abstract The role of the mitochondria in disease, general health and aging has drawn much attention over the years. Several attempts have been made to describe how the numbers of mitochondria correlate with age, although with inconclusive results. In this study, the relative quantity of mitochondrial DNA compared to nuclear DNA, i.e. the mitochondrial DNA copy number, was measured by PCR technology and used as a proxy for the content of mitochondria copies. In 1,067 Danish twins and singletons (18–93 years of age), with the majority being elderly individuals, the estimated mean mitochondrial DNA copy number in peripheral blood cells was similar for those 18–48 years of age [mean relative mtDNA content: 61.0; 95 % CI (52.1; 69.9)], but declined by −0.54 mtDNA 95 % CI (−0.63; −0.45) every year for those older than approximately 50 years of age. However, the longitudinal, yearly decline within an individual was more than twice as steep as observed in the cross-sectional analysis [decline of mtDNA content: −1.27; 95 % CI (−1.71; −0.82)]. Subjects with low mitochondrial DNA copy number had poorer outcomes in terms of cognitive performance, physical strength, self-rated health, and higher all-cause mortality than subjects with high mitochondrial DNA copy number, also when age was controlled for. The copy number mortality association can contribute to the smaller decline in a cross-sectional sample of the population compared to the individual, longitudinal decline. This study suggests that high mitochondrial DNA copy number in blood is associated with better health and survival among elderly.
AbstractList The role of the mitochondria in disease, general health and aging has drawn much attention over the years. Several attempts have been made to describe how the numbers of mitochondria correlate with age, although with inconclusive results. In this study, the relative quantity of mitochondrial DNA compared to nuclear DNA, i.e. the mitochondrial DNA copy number, was measured by PCR technology and used as a proxy for the content of mitochondria copies. In 1,067 Danish twins and singletons (18-93 years of age), with the majority being elderly individuals, the estimated mean mitochondrial DNA copy number in peripheral blood cells was similar for those 18-48 years of age [mean relative mtDNA content: 61.0; 95 % CI (52.1; 69.9)], but declined by -0.54 mtDNA 95 % CI (-0.63; -0.45) every year for those older than approximately 50 years of age. However, the longitudinal, yearly decline within an individual was more than twice as steep as observed in the cross-sectional analysis [decline of mtDNA content: -1.27; 95 % CI (-1.71; -0.82)]. Subjects with low mitochondrial DNA copy number had poorer outcomes in terms of cognitive performance, physical strength, self-rated health, and higher all-cause mortality than subjects with high mitochondrial DNA copy number, also when age was controlled for. The copy number mortality association can contribute to the smaller decline in a cross-sectional sample of the population compared to the individual, longitudinal decline. This study suggests that high mitochondrial DNA copy number in blood is associated with better health and survival among elderly.
The role of the mitochondria in disease, general health and aging has drawn much attention over the years. Several attemptshave been made to describe how the numbersof mitochondriacorrelate with age, although with inconclusive results. In this study, the relativequantity of mitochondrial DNA compared to nuclear DNA,i.e. the mitochondrial DNA copy number, was measured by PCR technology and used as a proxy for the content of mitochondria copies. In 1,067 Danish twins and singletons (18-93 years of age), with the majority being elderly individuals, theestimated mean mitochondrial DNA copy numberin peripheral blood cells was similar for those 18-48 years of age (mean relative mtDNA content: 61.0; 95% CI [52.1; 69.9]), but declinedby −0.54 mtDNA 95%CI [−0.63; −0.45] every year for those older thanapproximately 50 years of age.However, the longitudinal, yearly decline within an individual was more than twice as steep as observed in the cross-sectional analysis (decline of mtDNA content: −1.27; 95%CI [−1.71; −0.82]). Subjects with low mitochondrial DNA copy numberhad poorer outcomes in terms of cognitive performance, physical strength, self-rated health, andhigher all-cause mortality than subjects with high mitochondrial DNA copy number, also when age was controlled for.The copy numbermortality associationcan contribute to the smaller decline in a cross-sectional sample of the population compared to the individual,longitudinal decline. This study suggests that high mitochondrial DNA copy number in blood is associated with betterhealth and survival among elderly.
The role of the mitochondria in disease, general health and aging has drawn much attention over the years. Several attempts have been made to describe how the numbers of mitochondria correlate with age, although with inconclusive results. In this study, the relative quantity of mitochondrial DNA compared to nuclear DNA, i.e. the mitochondrial DNA copy number, was measured by PCR technology and used as a proxy for the content of mitochondria copies. In 1,067 Danish twins and singletons (18-93 years of age), with the majority being elderly individuals, the estimated mean mitochondrial DNA copy number in peripheral blood cells was similar for those 18-48 years of age [mean relative mtDNA content: 61.0; 95 % CI (52.1; 69.9)], but declined by -0.54 mtDNA 95 % CI (-0.63; -0.45) every year for those older than approximately 50 years of age. However, the longitudinal, yearly decline within an individual was more than twice as steep as observed in the cross-sectional analysis [decline of mtDNA content: -1.27; 95 % CI (-1.71; -0.82)]. Subjects with low mitochondrial DNA copy number had poorer outcomes in terms of cognitive performance, physical strength, self-rated health, and higher all-cause mortality than subjects with high mitochondrial DNA copy number, also when age was controlled for. The copy number mortality association can contribute to the smaller decline in a cross-sectional sample of the population compared to the individual, longitudinal decline. This study suggests that high mitochondrial DNA copy number in blood is associated with better health and survival among elderly.[PUBLICATION ABSTRACT]
The role of the mitochondria in disease, general health and aging has drawn much attention over the years. Several attempts have been made to describe how the numbers of mitochondria correlate with age, although with inconclusive results. In this study, the relative quantity of mitochondrial DNA compared to nuclear DNA, i.e. the mitochondrial DNA copy number, was measured by PCR technology and used as a proxy for the content of mitochondria copies. In 1,067 Danish twins and singletons (18-93 years of age), with the majority being elderly individuals, the estimated mean mitochondrial DNA copy number in peripheral blood cells was similar for those 18-48 years of age [mean relative mtDNA content: 61.0; 95 % CI (52.1; 69.9)], but declined by -0.54 mtDNA 95 % CI (-0.63; -0.45) every year for those older than approximately 50 years of age. However, the longitudinal, yearly decline within an individual was more than twice as steep as observed in the cross-sectional analysis [decline of mtDNA content: -1.27; 95 % CI (-1.71; -0.82)]. Subjects with low mitochondrial DNA copy number had poorer outcomes in terms of cognitive performance, physical strength, self-rated health, and higher all-cause mortality than subjects with high mitochondrial DNA copy number, also when age was controlled for. The copy number mortality association can contribute to the smaller decline in a cross-sectional sample of the population compared to the individual, longitudinal decline. This study suggests that high mitochondrial DNA copy number in blood is associated with better health and survival among elderly.The role of the mitochondria in disease, general health and aging has drawn much attention over the years. Several attempts have been made to describe how the numbers of mitochondria correlate with age, although with inconclusive results. In this study, the relative quantity of mitochondrial DNA compared to nuclear DNA, i.e. the mitochondrial DNA copy number, was measured by PCR technology and used as a proxy for the content of mitochondria copies. In 1,067 Danish twins and singletons (18-93 years of age), with the majority being elderly individuals, the estimated mean mitochondrial DNA copy number in peripheral blood cells was similar for those 18-48 years of age [mean relative mtDNA content: 61.0; 95 % CI (52.1; 69.9)], but declined by -0.54 mtDNA 95 % CI (-0.63; -0.45) every year for those older than approximately 50 years of age. However, the longitudinal, yearly decline within an individual was more than twice as steep as observed in the cross-sectional analysis [decline of mtDNA content: -1.27; 95 % CI (-1.71; -0.82)]. Subjects with low mitochondrial DNA copy number had poorer outcomes in terms of cognitive performance, physical strength, self-rated health, and higher all-cause mortality than subjects with high mitochondrial DNA copy number, also when age was controlled for. The copy number mortality association can contribute to the smaller decline in a cross-sectional sample of the population compared to the individual, longitudinal decline. This study suggests that high mitochondrial DNA copy number in blood is associated with better health and survival among elderly.
The role of the mitochondria in disease, general health and aging has drawn much attention over the years. several attempts have been made to describe how the numbers of mitochondria correlate with age, although with inconclusive results. In this study, the relative quantity of mitochondrial DNA compared to nuclear DNA, i.e. the mitochondrial DNA copy number, was measured by PCR technology and used as a proxy for the content of mitochondria copies. In 1,067 Danish twins and singletons (1893 years of age), with the majority being elderly individuals, the estimated mean mitochondrial DNA copy number in peripheral blood cells was similar for those 18-48 years of age [mean relative mtDNA content: 61.0; 95% CI (52.1; 69.9)], but declined by -0.54 mtDNA 95% CI (-0.63; -0.45) every year for those older than approximately 50 years of age. However, the longitudinal, yearly decline within an individual was more than twice as steep as observed in the cross-sectional analysis [decline of mtDNA content: -1.27; 95% CI (-1.71; -0.82)]. Subjects with low mitochondrial DNA copy number had poorer outcomes in terms of cognitive performance, physical strength, self-rated health, and higher all-cause mortality than subjects with high mitochondrial DNA copy number, also when age was controlled for. The copy number mortality association can contribute to the smaller decline in a cross-sectional sample of the population compared to the individual, longitudinal decline. This study suggests that high mitochondrial DNA copy number in blood is associated with better health and survival among elderly.
The role of the mitochondria in disease, general health and aging has drawn much attention over the years. Several attempts have been made to describe how the numbers of mitochondria correlate with age, although with inconclusive results. In this study, the relative quantity of mitochondrial DNA compared to nuclear DNA, i.e. the mitochondrial DNA copy number, was measured by PCR technology and used as a proxy for the content of mitochondria copies. In 1,067 Danish twins and singletons (18–93 years of age), with the majority being elderly individuals, the estimated mean mitochondrial DNA copy number in peripheral blood cells was similar for those 18–48 years of age [mean relative mtDNA content: 61.0; 95 % CI (52.1; 69.9)], but declined by −0.54 mtDNA 95 % CI (−0.63; −0.45) every year for those older than approximately 50 years of age. However, the longitudinal, yearly decline within an individual was more than twice as steep as observed in the cross-sectional analysis [decline of mtDNA content: −1.27; 95 % CI (−1.71; −0.82)]. Subjects with low mitochondrial DNA copy number had poorer outcomes in terms of cognitive performance, physical strength, self-rated health, and higher all-cause mortality than subjects with high mitochondrial DNA copy number, also when age was controlled for. The copy number mortality association can contribute to the smaller decline in a cross-sectional sample of the population compared to the individual, longitudinal decline. This study suggests that high mitochondrial DNA copy number in blood is associated with better health and survival among elderly.
Audience Academic
Author Thinggaard, Mikael
Mengel-From, Jonas
Christiansen, Lene
Kyvik, Kirsten Ohm
Christensen, Kaare
Dalgård, Christine
AuthorAffiliation 2 Department of Clinical Genetics, Odense University Hospital, Sdr. Boulevard 29, DK-5000, Odense, Denmark
3 Department of Environmental Medicine, Institute of Public Health, University ofSouthern Denmark, J.B. WinsløwsVej17A, DK-5000 Odense, Denmark
4 Institute of Regional Health Research, University of Southern Denmark And Odense Patient data Explorative Network (OPEN), Odense University Hospital
5 Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Sdr. Boulevard 29, DK-5000, Odense, Denmark
1 The Danish Aging Research Center and The Danish Twin Registry, Epidemiology Unit, Institute of Public Health, University ofSouthern Denmark, J.B. WinsløwsVej 9, DK-5000 Odense, Denmark
AuthorAffiliation_xml – name: 2 Department of Clinical Genetics, Odense University Hospital, Sdr. Boulevard 29, DK-5000, Odense, Denmark
– name: 3 Department of Environmental Medicine, Institute of Public Health, University ofSouthern Denmark, J.B. WinsløwsVej17A, DK-5000 Odense, Denmark
– name: 5 Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Sdr. Boulevard 29, DK-5000, Odense, Denmark
– name: 1 The Danish Aging Research Center and The Danish Twin Registry, Epidemiology Unit, Institute of Public Health, University ofSouthern Denmark, J.B. WinsløwsVej 9, DK-5000 Odense, Denmark
– name: 4 Institute of Regional Health Research, University of Southern Denmark And Odense Patient data Explorative Network (OPEN), Odense University Hospital
Author_xml – sequence: 1
  givenname: Jonas
  surname: Mengel-From
  fullname: Mengel-From, Jonas
  email: jmengel-from@health.sdu.dk
  organization: Epidemiology, Biostatistics and Biodemography Unit, The Danish Aging Research Center, The Danish Twin Registry, Institute of Public Health, University of Southern Denmark, Department of Clinical Genetics, Odense University Hospital
– sequence: 2
  givenname: Mikael
  surname: Thinggaard
  fullname: Thinggaard, Mikael
  organization: Epidemiology, Biostatistics and Biodemography Unit, The Danish Aging Research Center, The Danish Twin Registry, Institute of Public Health, University of Southern Denmark
– sequence: 3
  givenname: Christine
  surname: Dalgård
  fullname: Dalgård, Christine
  organization: Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark
– sequence: 4
  givenname: Kirsten Ohm
  surname: Kyvik
  fullname: Kyvik, Kirsten Ohm
  organization: Institute of Regional Health Research, University of Southern Denmark, Odense Patient Data Explorative Network (OPEN), Odense University Hospital
– sequence: 5
  givenname: Kaare
  surname: Christensen
  fullname: Christensen, Kaare
  organization: Epidemiology, Biostatistics and Biodemography Unit, The Danish Aging Research Center, The Danish Twin Registry, Institute of Public Health, University of Southern Denmark, Department of Clinical Genetics, Odense University Hospital, Department of Clinical Biochemistry and Pharmacology, Odense University Hospital
– sequence: 6
  givenname: Lene
  surname: Christiansen
  fullname: Christiansen, Lene
  organization: Epidemiology, Biostatistics and Biodemography Unit, The Danish Aging Research Center, The Danish Twin Registry, Institute of Public Health, University of Southern Denmark
BackLink https://www.ncbi.nlm.nih.gov/pubmed/24902542$$D View this record in MEDLINE/PubMed
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SSID ssj0015925
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Snippet The role of the mitochondria in disease, general health and aging has drawn much attention over the years. Several attempts have been made to describe how the...
The role of the mitochondria in disease, general health and aging has drawn much attention over the years. several attempts have been made to describe how the...
The role of the mitochondria in disease, general health and aging has drawn much attention over the years. Several attemptshave been made to describe how the...
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Index Database
Enrichment Source
Publisher
StartPage 1149
SubjectTerms Adolescent
Adult
Age
Age Factors
Aged
Aged, 80 and over
Aging
Aging - genetics
Analysis
Biomarkers
Biomedical and Life Sciences
Biomedicine
Blood
Body Mass Index
Cross-Sectional Studies
Denmark
DNA Copy Number Variations
DNA, Mitochondrial - blood
DNA, Mitochondrial - genetics
Female
Gene Function
Genetic research
Genomes
Health aspects
Hospitals
Human Genetics
Humans
Leukocytes
Longitudinal Studies
Lung cancer
Male
Metabolic Diseases
Middle Aged
Mitochondria
Mitochondrial DNA
Molecular Medicine
Mortality
Mutation
Original Investigation
Oxidative stress
Public health
Self Report
Twins
Young Adult
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Title Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly
URI https://link.springer.com/article/10.1007/s00439-014-1458-9
https://www.ncbi.nlm.nih.gov/pubmed/24902542
https://www.proquest.com/docview/1552150126
https://www.proquest.com/docview/1552371362
https://www.proquest.com/docview/1560123956
https://pubmed.ncbi.nlm.nih.gov/PMC4127366
Volume 133
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