Improving the coverage and accuracy of syphilis testing: The development of a novel rapid, point-of-care test for confirmatory testing of active syphilis infection and its early evaluation in China and South Africa

• Published in: EClinicalMedicine Vol. 24; p. 100440
• Main Authors: Pham, Minh D., Wise, Amy, Garcia, Mary L., Van, Huy, Zheng, Shuning, Mohamed, Yasmin, Han, Yan, Wei, Wan-Hui, Yin, Yue-Ping, Chen, Xiang-Sheng, Dimech, Wayne, Braniff, Susie, Technau, Karl-Günter, Luchters, Stanley, Anderson, David A.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2020; Elsevier
• Subjects: China; Diagnostic accuracy; IgA; Internal Medicine; Point of care test; Research paper; South Africa; Syphilis; South Africa; IgA; Syphilis; Diagnostic accuracy; China; Point of care test

Current point-of-care tests (POCT) for syphilis, based on the detection of Treponema pallidum (TP) total antibodies, have limited capacity in distinguishing between active and past/treated syphilis. We report the development and early evaluation of a new prototype POCT based on the detection of TP-I...