P-glycoprotein ABCB1: a major player in drug handling by mammals

• Published in: The Journal of clinical investigation Vol. 123; no. 10; pp. 4131 - 4133
• Main Authors: Borst, Piet, Schinkel, Alfred H.
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.10.2013
• Subjects: Animals; ATP-Binding Cassette, Sub-Family B, Member 1 - physiology; Biological Transport; Biomedical research; Blood-brain barrier; Blood-Brain Barrier - metabolism; Brain; Carrier proteins; Genes; Genetic aspects; Genetically modified mice; Glycoproteins; Hindsight; Humans; Intestinal Absorption; Mice; Mice, Knockout; Properties; Rodents; Stem cells; Tissue Distribution; Netherlands

Mammalian P-glycoproteins are active drug efflux transporters located in the plasma membrane. In the early nineties, we generated knockouts of the three P-glycoprotein genes of mice, the Mdr1a, Mdr1b, and Mdr2 P-glycoproteins, now known as Abcb1a, Abcb1b, and Abcb4, respectively. In the JCI papers t...