What renders Bacilli genetically competent? A gaze beyond the model organism

• Published in: Applied microbiology and biotechnology Vol. 99; no. 4; pp. 1557 - 1570
• Main Authors: Jakobs, Mareike, Meinhardt, Friedhelm
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.02.2015; Springer Berlin Heidelberg; Springer; Springer Nature B.V
• Subjects: Analysis; Bacilli; Bacillus (Bacteria); Bacillus licheniformis; Bacillus subtilis; Bacillus subtilis - genetics; Bacteria; Biomedical and Life Sciences; biosafety; Biotechnology; Cell density; Coma; Deoxyribonucleic acid; Deregulation; DNA; DNA - genetics; DNA - metabolism; DNA Transformation Competence; Domestication; Gene expression; Gene Expression Regulation, Bacterial; Gene Regulatory Networks; Genes; Genetic aspects; Genetic engineering; Genetic transformation; Genetics; Genomics; Gram-positive bacteria; Identification and classification; Industrial applications; Kinases; Laboratories; Life Sciences; Microbial Genetics and Genomics; Microbiology; Mini-Review; Mutation; Organisms; Peptides; Phosphatase; Point mutation; Quorum sensing; regulator genes; Sensors; Signal transduction; Strains (organisms); Studies; Transformation, Bacterial; Bacilli; Quorum sensing; Natural genetic competence; DNA uptake

Natural genetic competence enables bacteria to take in and establish exogenously supplied DNA and thus constitutes a valuable tool for strain improvement. Extensively studied in the Gram-positive model organism Bacillus subtilis genetic competence has indeed proven successful for genetic manipulatio...