SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis

• Published in: JACC. Basic to translational science Vol. 6; no. 4; pp. 331 - 345
• Main Authors: Bailey, Adam L., Dmytrenko, Oleksandr, Greenberg, Lina, Bredemeyer, Andrea L., Ma, Pan, Liu, Jing, Penna, Vinay, Winkler, Emma S., Sviben, Sanja, Brooks, Erin, Nair, Ajith P., Heck, Kent A., Rali, Aniket S., Simpson, Leo, Saririan, Mehrdad, Hobohm, Dan, Stump, W. Tom, Fitzpatrick, James A., Xie, Xuping, Zhang, Xianwen, Shi, Pei-Yong, Hinson, J. Travis, Gi, Weng-Tein, Schmidt, Constanze, Leuschner, Florian, Lin, Chieh-Yu, Diamond, Michael S., Greenberg, Michael J., Lavine, Kory J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2021; Elsevier
• Subjects: cardiomyocyte; Cardiovascular; Clinical Research; coronavirus disease 2019; engineered heart tissue; myocarditis; severe acute respiratory syndrome coronavirus 2; COVID-19; EHT; ACE2; SARS-CoV-2; severe acute respiratory syndrome coronavirus 2; coronavirus disease 2019; myocarditis; cardiomyocyte; hPSC; engineered heart tissue; LV; coronavirus disease-2019; human pluripotent stem cell(s); left ventricle; engineered heart tissues; angiotensin converting enzyme 2; severe acute respiratory syndrome-coronavirus-2; ACE2, angiotensin converting enzyme 2; LV, left ventricle; COVID-19, coronavirus disease-2019; SARS-CoV-2, severe acute respiratory syndrome-coronavirus-2; hPSC, human pluripotent stem cell(s); EHT, engineered heart tissues

[Display omitted] •SARS-CoV-2 directly infects cardiomyocytes in patients with COVID-19 myocarditis and does not infect cardiac macrophages, fibroblasts, or endothelial cells.•COVID-19 myocarditis is characterized by a myeloid-rich inflammatory infiltrate.•SARS-CoV-2 infects cardiomyocytes through a...