A NOVEL CLASS OF PLATELET ACTIVATING FACTOR ANTAGONISTS FROM Phoma sp
Four novel platelet activating factor (PAF) antagonists, Sch 47918, Sch 49026, Sch 49027 and Sch 49028, were isolated from the fermentation broth of the fungal culture, Phoma sp. (ATCC 74077). The structures of these compounds were elucidated by spectroscopic methods. The structure and stereochemist...
Saved in:
| Published in | Journal of antibiotics Vol. 46; no. 4; pp. 554 - 563 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
TOKYO
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
1993
JAPAN ANTIBIOT RES ASSN Japan Antibiotics Research Association |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Four novel platelet activating factor (PAF) antagonists, Sch 47918, Sch 49026, Sch 49027 and Sch 49028, were isolated from the fermentation broth of the fungal culture, Phoma sp. (ATCC 74077). The structures of these compounds were elucidated by spectroscopic methods. The structure and stereochemistry of the first isolated component, Sch 47918, were confirmed by single crystal X-ray diffraction analysis. Sch 49028, the most active component, was found to inhibit PAF-induced human platelet aggregation in vitro with an IC50 of 1.26 μM. However, this compound was inactive in vivo at 5 mg/kg, iv against PAF-induced bronchospasm in guinea pigs. |
|---|---|
| AbstractList | Four novel platelet activating factor (PAF) antagonists, Sch 47918, Sch 49026, Sch 49027 and Sch 49028, were isolated from the fermentation broth of the fungal culture, Phoma sp. (ATCC 74077). The structures of these compounds were elucidated by spectroscopic methods. The structure and stereochemistry of the first isolated component, Sch 47918, were confirmed by single crystal X-ray diffraction analysis. Sch 49028, the most active component, was found to inhibit PAF-induced human platelet aggregation in vitro with an IC50 of 1.26 microM. However, this compound was inactive in vivo at 5 mg/kg, iv against PAF-induced bronchospasm in guinea pigs. Four novel platelet activating factor (PAF) antagonists, Sch 47918, Sch 49026, Sch 49027 and Sch 49028, were isolated from the fermentation broth of the fungal culture, Phoma sp. (ATCC 74077). The structures of these compounds were elucidated by spectroscopic methods. The structure and stereochemistry of the first isolated component, Sch 47918, were confirmed by single crystal X-ray diffraction analysis. Sch 49028, the most active component, was found to inhibit PAF-induced human platelet aggregation in vitro with an IC50 of 1.26 μM. However, this compound was inactive in vivo at 5 mg/kg, iv against PAF-induced bronchospasm in guinea pigs. Four novel platelet activating factor (PAF) antagonists, Sch 47918, Sch 49026, Sch 49027 and Sch 49028, were isolated from the fermentation broth of the fungal culture, Phoma sp. (ATCC 74077). The structures of these compounds were elucidated by spectroscopic methods. The structure and stereochemistry of the first isolated component, Sch 47918, were confirmed by single crystal X-ray diffraction analysis. Sch 49018, the most active component, was found to inhibit PAF-induced human platelet aggregation in vitro with an IC sub(50) of 1.26 mu M. However, this compound was inactive in vivo at 5 mg/kg, iv against PAF-induced bronchospasm in guinea pigs. Four novel platelet activating factor (PAF) antagonists, Sch 47918, Sch 49026, Sch 49027 and Sch 49028, were isolated from the fermentation broth of the fungal culture, Phoma sp. (ATCC 74077). The structures of these compounds were elucidated by spectroscopic methods. The structure and stereochemistry of the first isolated component, Sch 47918, were confirmed by single crystal X-ray diffraction analysis. Sch 49028, the most active component, was found to inhibit PAF-induced human platelet aggregation in vitro with an IC50 of 1.26 mum. However, this compound was inactive in vivo at 5 mg/kg, iv against PAF-induced bronchospasm in guinea pigs. |
| Author | TRUUMEES, IMBI GULLO, VINCENT P. GUNNARSSON, IJI BISHOP, W. ROBERT HORAN, ANN C. PUAR, MOHINDAR S. CHU, MIN KREUTNER, WILLIAM PATEL, MAHESH G. |
| Author_xml | – sequence: 1 fullname: CHU, MIN organization: Schering-Plough-Research Institute – sequence: 2 fullname: TRUUMEES, IMBI organization: Schering-Plough-Research Institute – sequence: 3 fullname: GUNNARSSON, IJI organization: Schering-Plough-Research Institute – sequence: 4 fullname: BISHOP, W. ROBERT organization: Schering-Plough-Research Institute – sequence: 5 fullname: KREUTNER, WILLIAM organization: Schering-Plough-Research Institute – sequence: 6 fullname: HORAN, ANN C. organization: Schering-Plough-Research Institute – sequence: 7 fullname: PATEL, MAHESH G. organization: Schering-Plough-Research Institute – sequence: 8 fullname: GULLO, VINCENT P. organization: Schering-Plough-Research Institute – sequence: 9 fullname: PUAR, MOHINDAR S. organization: Schering-Plough-Research Institute |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4787568$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/8500998$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkF9r2zAUxcXo6NJuX2Aw0MPYy3AmWX_9aIyThnpxabw-7MXIsry6OFJqOYx9-9o4ZH3b7oOu4P7OgXOuwIV11gDwEaOlwJx-U3Zoq9YNrfZLypeM0TdggaXEAaY8ugALhEIcSBmid-DK-yeEiCBCXoJLyRCKIrkAaQy3-UOawSSLdzuYr-BdFhdplhYwTorNQ1xstmu4Gv_5PYy3RbzOt5tdsYOr-_w7vHt0ewX94T1426jOmw-nfQ1-rNIiuQmyfL1J4izQnIghkJpFKlRC10IxKgyuRRUxhbUSnArWYI7qSsqaIN5wEQmBNGY10bwmjUCKkmvwZfY99O75aPxQ7luvTdcpa9zRl4IJwhkh_wQx50iGdHIMZ1D3zvveNOWhb_eq_1NiVE4ll69KLikvx5JH0aeT-7Ham_osObU63j-f7spr1TW9srr1Z4wKKRifsK8z9ttUrvG6NVabMxXjKCK3PwmXaJwpkvx_OmkHNbTOJu5oh1F6O0uf_KB-_RWpfkzVmdcRccTlFJPOz5j2TOlH1ZfGkhcBXb-b |
| CODEN | JANTAJ |
| CitedBy_id | crossref_primary_10_1021_acs_jnatprod_2c00249 crossref_primary_10_1002_ange_201400932 crossref_primary_10_1016_S0040_4039_03_00341_1 crossref_primary_10_1016_j_lfs_2003_06_001 crossref_primary_10_1016_S0040_4039_03_00880_3 crossref_primary_10_1002_anie_201503822 crossref_primary_10_1021_acs_orglett_5b00586 crossref_primary_10_1002_anie_202312996 crossref_primary_10_1016_j_cclet_2022_05_027 crossref_primary_10_1021_ja0296531 crossref_primary_10_1039_b502792f crossref_primary_10_1080_00304948_2014_903142 crossref_primary_10_1016_j_bmcl_2005_04_048 crossref_primary_10_1039_b415080p crossref_primary_10_1016_j_tet_2012_08_013 crossref_primary_10_1007_s00253_018_9329_2 crossref_primary_10_1016_S0040_4039_00_60393_3 crossref_primary_10_1021_acs_orglett_8b03242 crossref_primary_10_1039_b903256h crossref_primary_10_1246_bcsj_75_203 crossref_primary_10_1002_ange_201503822 crossref_primary_10_1021_ol070904q crossref_primary_10_1039_B307986D crossref_primary_10_1016_j_tetlet_2007_04_122 crossref_primary_10_1016_j_tet_2010_02_040 crossref_primary_10_1039_B314816E crossref_primary_10_1002_ange_202312996 crossref_primary_10_1002_anie_201400932 crossref_primary_10_1016_0040_4039_96_01585_7 crossref_primary_10_1016_j_tet_2009_03_031 crossref_primary_10_1016_j_tet_2011_09_111 crossref_primary_10_1002_slct_202304204 crossref_primary_10_1038_s41557_018_0084_x crossref_primary_10_1016_j_tetlet_2009_03_042 crossref_primary_10_1021_jo200936r crossref_primary_10_1039_D2OB00585A crossref_primary_10_1021_jacs_0c07316 crossref_primary_10_1002_prac_19983400702 crossref_primary_10_1016_0040_4039_95_02148_5 crossref_primary_10_1039_b407236g crossref_primary_10_1016_j_tetlet_2016_08_016 crossref_primary_10_1021_acs_jnatprod_3c00383 crossref_primary_10_3390_md8082340 crossref_primary_10_1039_b506411b crossref_primary_10_1021_ol0061788 crossref_primary_10_1016_S0041_1345_03_00440_8 |
| ContentType | Journal Article |
| Copyright | Japan Antibiotics Research Association 1993 INIST-CNRS |
| Copyright_xml | – notice: Japan Antibiotics Research Association – notice: 1993 INIST-CNRS |
| DBID | 1KM BLEPL DTL EZIWH IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QO 7T7 8FD C1K FR3 M7N P64 7X8 |
| DOI | 10.7164/antibiotics.46.554 |
| DatabaseName | Index Chemicus Web of Science Core Collection Science Citation Index Expanded Web of Science - Science Citation Index Expanded - 1993 Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Biotechnology Research Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
| DatabaseTitle | Web of Science MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Biotechnology Research Abstracts Technology Research Database Algology Mycology and Protozoology Abstracts (Microbiology C) Engineering Research Database Industrial and Applied Microbiology Abstracts (Microbiology A) Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic |
| DatabaseTitleList | MEDLINE Biotechnology Research Abstracts MEDLINE - Academic Web of Science |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 1KM name: Index Chemicus url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/woscc/search-with-editions?editions=WOS.IC sourceTypes: Enrichment Source Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1881-1469 |
| EndPage | 563 |
| ExternalDocumentID | 10_7164_antibiotics_46_554 8500998 4787568 A1993KZ36800003 article_antibiotics1968_46_4_46_4_554_article_char_en |
| Genre | Journal Article |
| GroupedDBID | --- -~X .55 .GJ 2WC 3O- 53G 5GY AAUGY ABAWZ ACGFS AENEX AHMBA ALMA_UNASSIGNED_HOLDINGS DU5 F5P JSF JSH KQ8 OK1 RJT RNT RZJ TKC UPT W2D X7M YQT ZGI ZXP 1KM ABJNI ALIPV BLEPL DTL GROUPED_WOS_SCIENCE_CITATION_INDEX_EXPANDED -Q- 0R~ 29J 39C 3V. 4.4 41~ 70F 7X7 88E 88I 8FI 8FJ 8W4 AABQG AADWK AANZL AAWBL AAYJO AAZLF ABDEU ABFLS ABUWG ACBMV ACBRV ACBYP ACIGE ACKTT ACRQY ACTTH ACVWB ADBBV ADGIM ADHDB ADMDM ADQMX ADTIX ADYYL AEDAW AEFTE AEJRE AEXYK AFKRA AFSHS AGAYW AGEZK AGGBP AGHAI AHSBF AILAN AJDOV AJRNO ALFFA AMRJV AMYLF AXYYD AZQEC BAWUL BBAFP BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI DIK DNIVK DWQXO EBLON EBS EE. EIOEI EJD EMB EMOBN FDQFY FERAY FIZPM FSGXE FYUFA GNUQQ HCIFZ HZ~ IQODW JSO JZLTJ M1P M2P M7P NAO NQJWS NYICJ O9- P6G PQEST PQQKQ PQUKI PROAC PSQYO RNTTT SNX SNYQT SRMVM SV3 SWTZT TAOOD TBHMF TDRGL TR2 TSG UKHRP X7J 406 AACDK AASML AATNV ABAKF ABZZP ACAOD ACZOJ AEFQL AEMSY AEVLU AFBBN AGQEE AIGIU CCPQU CGR CUY CVF DPUIP ECM EIF FIGPU HMCUK IWAJR NPM SOHCF AAYXX CITATION 7QO 7T7 8FD C1K FR3 M7N P64 7X8 |
| ID | FETCH-LOGICAL-c637t-8c59a2a7cd7a547e1d7b95a1ca76475f160db88d306f679770c15d3c6d3f70a43 |
| ISICitedReferencesCount | 55 |
| ISICitedReferencesURI | https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=CitingArticles&UT=A1993KZ36800003 |
| ISSN | 0021-8820 |
| IngestDate | Sat Aug 17 00:20:21 EDT 2024 Sat Aug 17 02:01:51 EDT 2024 Fri Aug 23 00:43:17 EDT 2024 Sat Sep 28 08:40:33 EDT 2024 Fri Nov 25 05:59:47 EST 2022 Fri Nov 08 20:16:12 EST 2024 Wed Sep 18 01:47:18 EDT 2024 Thu Aug 17 20:29:34 EDT 2023 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | MICROBIAL PRODUCTS RABBIT FACTOR PAF ANTAGONISTS DITERPENE FR-900452 Respiratory disease Fermentation In vitro Biological activity Antiallergic Platelet activating factor Fungi Aggregation Non steroidal antiinflammatory agent Bronchospasm In vivo Bronchoconstriction Chemotherapy Platelet Phoma Treatment Microbial origin Structure activity relation Animal Isolation Fungi Imperfecti Antagonist Physicochemical properties Thallophyta |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | OpenURL |
| LogoURL | https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg |
| MergedId | FETCHMERGED-LOGICAL-c637t-8c59a2a7cd7a547e1d7b95a1ca76475f160db88d306f679770c15d3c6d3f70a43 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/antibiotics1968/46/4/46_4_554/_article/-char/en |
| PMID | 8500998 |
| PQID | 16608244 |
| PQPubID | 23462 |
| PageCount | 10 |
| ParticipantIDs | pascalfrancis_primary_4787568 webofscience_primary_A1993KZ36800003 proquest_miscellaneous_75736533 proquest_miscellaneous_16608244 pubmed_primary_8500998 jstage_primary_article_antibiotics1968_46_4_46_4_554_article_char_en crossref_primary_10_7164_antibiotics_46_554 webofscience_primary_A1993KZ36800003CitationCount |
| PublicationCentury | 1900 |
| PublicationDate | 1993-00-00 |
| PublicationDateYYYYMMDD | 1993-01-01 |
| PublicationDate_xml | – year: 1993 text: 1993-00-00 |
| PublicationDecade | 1990 |
| PublicationPlace | TOKYO |
| PublicationPlace_xml | – name: TOKYO – name: Tokyo – name: Japan |
| PublicationTitle | Journal of antibiotics |
| PublicationTitleAbbrev | J ANTIBIOT |
| PublicationTitleAlternate | J. Antibiot. |
| PublicationYear | 1993 |
| Publisher | JAPAN ANTIBIOTICS RESEARCH ASSOCIATION JAPAN ANTIBIOT RES ASSN Japan Antibiotics Research Association |
| Publisher_xml | – name: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION – name: JAPAN ANTIBIOT RES ASSN – name: Japan Antibiotics Research Association |
| References | 2) KNAUER, K. A.; L. M. LICHTENSTEIN, N. F. ADKINSON, Jr. & J. E. FISH: Platelet activation during antigen-induced airway reactions in asthmatic subjects. N. Engl. J. Med. 304: 1404-1407, 1981 8) OKAMOTO, M.; K. YOSHIDA, I. UCHIDA, M. NISHIKAWA, M. KOHSAKA & H. AOKI: Studies of platelet activating factor (PAF) antagonists from microbial products. I. Bisdethiobis (methylthio)gliotoxin and its derivatives. Chem. Pharm. Bull. 34: 340-344, 1986 3) WEISS, H. J.: Platelet physiology and abnormalities of platelet function. N. Engl. J. Med. 293: 580-588, 1975 4) PRESCOTT, S. M.; G. A. ZIMMERMAN & T. M. MC!NTYRE: Platelet activating factor. J. Biol. Chem. 265: 17381-17384, 1990 9) YOSHIDA, K.; M. OKAMOTO, N. SHIMAZAKI & K. HEMMI: PAF inhibitors of microbial origin, studies on diketopiperazine derivatives. Prog. Biochem. Pharm. 22: 66-80, 1988 11) BOEREMA, G. H. & G. J. BOLLEN: Conidiogenesis and conidial septation as differentiating criteria between Phoma and Ascochyta. Persoonia 8: 111-114, 1975 5) OKAMOTO, M.; K. YOSHIDA, M. NISHIKAWA, T. ANDO, M. IWAMI, M. KOHSAKA & H. AOKI: FR-900452, a specific antagonist of platelet activating factor (PAF) produced by Streptomyces phaeofaciens. I. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics. J. Antibiotics 39: 198-204, 1986 15) SATO, A.; M. SUGANO, T. OSHIMA, H. HARUYAMA & K. FURUYA (Sankyo): Jpn. Pat. 03,216,197 ('91) [91,216,197], Sept. 24, 1991 13) HWANG, S.-B.; C. S. C. LEE, M. J. CHEAH & T. Y. SHEN: Specific receptor sites for 1-O-alkyl-2-O-acetyl-sn-glycero3-phosphocholine (platelet activating factor) on rabbit platelet and guinea pig smooth muscle membranes. Biochemistry 22: 4756-4763, 1983 6) OKAMOTO, M.; K. YOSHIDA, M. NISHIKAWA, M. KOHSAKA & H. AOKI: Platelet activating factor (PAF) involvement in endotoxin-induced thrombocytopenia in rabbits: studies with FR-900452, a specific inhibitor of PAF. Thromb. Res. 42: 661-671, 1986 7) OKAMOTO, M.; K. YOSHIDA, I. UCHIDA, M. KOHSAKA & H. AOKI: Studies of platelet activating factor (PAF) antagonists from microbial products. II. Pharmacological studies of FR-49175 in animal models. Chem. Pharm. Bull. 34: 345-348, 1986 16) MAHATO, S. B.; B. C. PAL, T. KAWASAKI, K. MIYAHARA, O. TANAKA & K. YAMASAKI: Structure of cleomeolide, a novel diterpene lactone from Cleome icosandra Linn. J. Am. Chem. Soc. 101: 4720-4723, 1979 14) KARLSSON, B.; A.-M. PILOTTI, A.-C. SÖDERHOLM, T. NORIN, S. SUNDIN & M. SUMIMOTO: The structure and absolute configuration of verticillol, a macrocyclic diterpene alcohol from the wood of Sciadipitys verticillata Sieb. et Zucc. (Taxodiaceae). Tetrahedron 34: 2349-2354, 1978 12) CHU, M.; M. G. PATEL, V. G. GULLO, I. TRUMEES, M. S. PUAR & A. T. MCPHAIL: Sch 47918, a novel PAF antagonist from the fungus Phoma sp. J. Org. Chem. 57: 5817-5818, 1992 10) JONG, S. C. & M. J. EDWARDS, (Eds.): The American Type Culture Collection Cataloque of Filamentous Fungi. 18th Edition. American Type Culture Collection, Reckville, Maryland, 1991 1) HENSON, P. M. & R. N. PINCKARD: Basophil-derived platelet-activating factor (PAF) as an in vivo mediator of acute allergic reactions: Demonstration of specific desensitization of platelets to PAF during IgE-induced anaphylaxis in the rabbit. J. Immunol. 119: 2179-2184, 1977 17) BURKE, B. A.; W. R. CHAN, V. A. HONKAN, J. F. BLOUNT & P. S. MANCHAND: The structure of cleomeolide, an unusual bicyclic diterpene from Cleome viscosa L. (Capparaceae). Tetrahedron 36: 3489-3493, 1980 WEISS, HJ (WOS:A1975AP99100004) 1975; 293 JONG SC (WOS:A1993KZ36800003.7) 1991 Yoshida, K (MEDLINE:2457219) 1988; 22 HWANG, SB (WOS:A1983RJ06700022) 1983; 22 KARLSSON, B (WOS:A1978FQ12400015) 1978; 34 HENSON, PM (WOS:A1977EC90600051) 1977; 119 KNAUER, KA (WOS:A1981LR62000007) 1981; 304 OKAMOTO, M (WOS:A1986A127900048) 1986; 34 PRESCOTT, SM (WOS:A1990EC76600001) 1990; 265 (WOS:A1993KZ36800003.1) 1991 OKAMOTO, M (WOS:A1986A207200004) 1986; 39 Boerema, G. H. (CABI:19751322452) 1975; 8 CHU, M (WOS:A1992JV47100008) 1992; 57 OKAMOTO, M (WOS:A1986C222200008) 1986; 42 MAHATO, SB (WOS:A1979HE80900048) 1979; 101 OKAMOTO, M (WOS:A1986A127900047) 1986; 34 BURKE, BA (WOS:A1980KW53100003) 1980; 36 |
| References_xml | – volume: 304 start-page: 1404 year: 1981 ident: WOS:A1981LR62000007 article-title: PLATELET ACTIVATION DURING ANTIGEN-INDUCED AIRWAY REACTIONS IN ASTHMATIC SUBJECTS publication-title: NEW ENGLAND JOURNAL OF MEDICINE contributor: fullname: KNAUER, KA – volume: 22 start-page: 66 year: 1988 ident: MEDLINE:2457219 article-title: PAF inhibitors of microbial origin. Studies on diketopiperazine derivatives. publication-title: Progress in biochemical pharmacology contributor: fullname: Yoshida, K – volume: 36 start-page: 3489 year: 1980 ident: WOS:A1980KW53100003 article-title: THE STRUCTURE OF CLEOMEOLIDE, AN UNUSUAL BICYCLIC DITERPENE FROM CLEOME-VISCOSA L (CAPPARACEAE) publication-title: TETRAHEDRON contributor: fullname: BURKE, BA – volume: 265 start-page: 17381 year: 1990 ident: WOS:A1990EC76600001 article-title: PLATELET-ACTIVATING FACTOR publication-title: JOURNAL OF BIOLOGICAL CHEMISTRY contributor: fullname: PRESCOTT, SM – year: 1991 ident: WOS:A1993KZ36800003.7 publication-title: AM TYPE CULTURE COLL contributor: fullname: JONG SC – volume: 39 start-page: 198 year: 1986 ident: WOS:A1986A207200004 article-title: FR-900452, A SPECIFIC ANTAGONIST OF PLATELET-ACTIVATING-FACTOR (PAF) PRODUCED BY STREPTOMYCES-PHAEOFACIENS .1. TAXONOMY, FERMENTATION, ISOLATION, AND PHYSICOCHEMICAL AND BIOLOGICAL CHARACTERISTICS publication-title: JOURNAL OF ANTIBIOTICS contributor: fullname: OKAMOTO, M – year: 1991 ident: WOS:A1993KZ36800003.1 – volume: 119 start-page: 2179 year: 1977 ident: WOS:A1977EC90600051 article-title: BASOPHIL-DERIVED PLATELET-ACTIVATING FACTOR (PAF) AS AN INVIVO MEDIATOR OF ACUTE ALLERGIC REACTIONS - DEMONSTRATION OF SPECIFIC DESENSITIZATION OF PLATELETS TO PAF DURING IGE-INDUCED ANAPHYLAXIS IN RABBIT publication-title: JOURNAL OF IMMUNOLOGY contributor: fullname: HENSON, PM – volume: 22 start-page: 4756 year: 1983 ident: WOS:A1983RJ06700022 article-title: SPECIFIC RECEPTOR-SITES FOR 1-O-ALKYL-2-O-ACETYL-SN-GLYCERO-3-PHOSPHOCHOLINE (PLATELET ACTIVATING FACTOR) ON RABBIT PLATELET AND GUINEA-PIG SMOOTH-MUSCLE MEMBRANES publication-title: BIOCHEMISTRY contributor: fullname: HWANG, SB – volume: 293 start-page: 580 year: 1975 ident: WOS:A1975AP99100004 article-title: PLATELET .2. PHYSIOLOGY AND ABNORMALITIES OF PLATELET-FUNCTION publication-title: NEW ENGLAND JOURNAL OF MEDICINE contributor: fullname: WEISS, HJ – volume: 42 start-page: 661 year: 1986 ident: WOS:A1986C222200008 article-title: PLATELET-ACTIVATING-FACTOR (PAF) INVOLVEMENT IN ENDOTOXIN-INDUCED THROMBOCYTOPENIA IN RABBITS - STUDIES WITH FR-900452, A SPECIFIC INHIBITOR OF PAF publication-title: THROMBOSIS RESEARCH contributor: fullname: OKAMOTO, M – volume: 57 start-page: 5817 year: 1992 ident: WOS:A1992JV47100008 article-title: SCH-47918 - A NOVEL PAF ANTAGONIST FROM THE FUNGUS PHOMA SP publication-title: JOURNAL OF ORGANIC CHEMISTRY contributor: fullname: CHU, M – volume: 34 start-page: 345 year: 1986 ident: WOS:A1986A127900048 article-title: STUDIES OF PLATELET-ACTIVATING-FACTOR (PAF) ANTAGONISTS FROM MICROBIAL PRODUCTS .2. PHARMACOLOGICAL STUDIES OF FR-49175 IN ANIMAL-MODELS publication-title: CHEMICAL & PHARMACEUTICAL BULLETIN contributor: fullname: OKAMOTO, M – volume: 34 start-page: 2349 year: 1978 ident: WOS:A1978FQ12400015 article-title: STRUCTURE AND ABSOLUTE-CONFIGURATION OF VERTICILLOL, A MACROCYCLIC DITERPENE ALCOHOL FROM WOOD OF SCIADOPITYS-VERTICILLATA SIEB ET ZUCC (TAXODIACEAE) publication-title: TETRAHEDRON contributor: fullname: KARLSSON, B – volume: 101 start-page: 4720 year: 1979 ident: WOS:A1979HE80900048 article-title: STRUCTURE OF CLEOMEOLIDE, A NOVEL DITERPENE LACTONE FROM CLEOME-ICOSANDRA LINN publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY contributor: fullname: MAHATO, SB – volume: 34 start-page: 340 year: 1986 ident: WOS:A1986A127900047 article-title: STUDIES OF PLATELET-ACTIVATING-FACTOR (PAF) ANTAGONISTS FROM MICROBIAL PRODUCTS .1. BISDETHIOBIS(METHYLTHIO)GLIOTOXIN AND ITS DERIVATIVES publication-title: CHEMICAL & PHARMACEUTICAL BULLETIN contributor: fullname: OKAMOTO, M – volume: 8 start-page: 111 year: 1975 ident: CABI:19751322452 article-title: Conidiogenesis and conidial septation as differentiating criteria between Phoma and Ascochyta. publication-title: Persoonia contributor: fullname: Boerema, G. H. |
| SSID | ssj0037378 |
| Score | 1.5851691 |
| Snippet | Four novel platelet activating factor (PAF) antagonists, Sch 47918, Sch 49026, Sch 49027 and Sch 49028, were isolated from the fermentation broth of the fungal... |
| Source | Web of Science |
| SourceID | proquest crossref pubmed pascalfrancis webofscience jstage |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 554 |
| SubjectTerms | Animals Biological and medical sciences Biotechnology & Applied Microbiology Bones, joints and connective tissue. Antiinflammatory agents Culture Media Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Fermentation Fungi - chemistry Fungi - growth & development Fungi - metabolism Guinea Pigs Humans Immunology Life Sciences & Biomedicine Male Medical sciences Microbiology Pharmacology & Pharmacy Pharmacology. Drug treatments Phoma Platelet Activating Factor - antagonists & inhibitors Rabbits Science & Technology Structure-Activity Relationship |
| Title | A NOVEL CLASS OF PLATELET ACTIVATING FACTOR ANTAGONISTS FROM Phoma sp |
| URI | https://www.jstage.jst.go.jp/article/antibiotics1968/46/4/46_4_554/_article/-char/en http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=FullRecord&UT=A1993KZ36800003 https://www.ncbi.nlm.nih.gov/pubmed/8500998 https://search.proquest.com/docview/16608244 https://search.proquest.com/docview/75736533 |
| Volume | 46 |
| WOS | A1993KZ36800003 |
| WOSCitedRecordID | wosA1993KZ36800003 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | The Journal of Antibiotics, 1993/04/25, Vol.46(4), pp.554-563 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELfK4AEJIb4mCgz8MO0lS4mb-KOPbSm0TGtLP6SJlyhxElRUNRVJkcZfzzlO3Wy00saLVaXnU-I7n-_su58ROqWRGzhJFNuSJo4NKwSxW5IowMsoCblIPBmrE93LIevPva9X9KpWW1eyljZ52JB_9taV_I9U4RnIVVXJ3kOyhik8gN8gX2hBwtDeScZta5X-jpeWVC5wkbu8BNdxqbZxpb62TKVJFjfqWDCCwY9U4eRmuqZkrFKDrGx9wD0F-kW4SPNKNny3Py_2Twfm-GY2mc8ve72prh7rmB3YL_PhsD2ZTkdFEsFgdwNzZzDtj8ZFYl_Dmow6vRIkMioL8dyqFW0SGzxzfZ4Sa8MpBLHB6raqlrXcXFxUtw0KM0k1cHS54lJt4m4bcxXJFSjG5nMbHmuYrlXk7FsrmskzhAhHcfErPHyP-cDjAXrYBNOkkkAvvplzJ5e75dpdfqEus1I8Pv77HjdcmUc_wZtXMA1P1kEG0yvR96LsC1z2-jiFPzN7hp6WksZtrVXPUS1evUBnY41kfn2OZ7vCvOwcn-HxDuP8-iXqtXGherhQPZwmeKt6eKd6WKserqgeVqqHC9XD2foVmn_uzbp9u7yRw5bM5bktJG0FzYDLiAfU4zGJeNiiAZEBZx6nCWFOFAoRQRyaMA6hhQPzPnIli9yEO4HnHqOjVbqKXyPcJCRyJBMklh4sIiTkocdFrNCkQsEFrSNrO7j-WgOv-IfFWUef9Pgb2nJSVmlhsRGK3tMNdDNUqsQRLEodndyQnuGmIKwoE3X0YStNH8ywOlsLVnG6yXzCGDjTnneYglPuMgiu6uhYq4FhLqiK04D5aVUtzN8KmNq9-O4yoZxL6E_uQtYtIf4VtEX-5l6D-RY91mm9aqPxHTrKf23iE3C98_B9MVv-ArlQ3F4 |
| link.rule.ids | 315,783,787,4031,27935,27936,27937 |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+novel+class+of+platelet+activating+factor+antagonists+from+Phoma+sp&rft.jtitle=Journal+of+antibiotics&rft.au=CHU%2C+MIN&rft.au=TRUUMEES%2C+IMBI&rft.au=GUNNARSSON%2C+IJI&rft.au=BISHOP%2C+W.+ROBERT&rft.date=1993&rft.issn=0021-8820&rft.eissn=1881-1469&rft.volume=46&rft.issue=4&rft.spage=554&rft.epage=563&rft_id=info:doi/10.7164%2Fantibiotics.46.554&rft.externalDBID=n%2Fa&rft.externalDocID=10_7164_antibiotics_46_554 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-8820&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-8820&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-8820&client=summon |