Zebrafish: An Important Tool for Liver Disease Research

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 149; no. 6; pp. 1361 - 1377
• Main Authors: Goessling, Wolfram, Sadler, Kirsten C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2015
• Subjects: Animals; Development; Disease Models, Animal; Gastroenterology and Hepatology; Humans; Liver - metabolism; Liver - pathology; Liver - physiopathology; Liver Cancer; Liver Diseases - genetics; Liver Diseases - metabolism; Liver Diseases - pathology; Liver Diseases - physiopathology; Regeneration; Technology; Toxicology; Zebrafish - genetics; Zebrafish - growth & development; Zebrafish - metabolism; DILI; DMBA; HCC; Liver Cancer; ER; GFP; Regeneration; NAC; Toxicology; Technology; UPR; ROS; Development; ALD; CYP; dpf; FLD; drug-induced liver injury; fatty liver disease; N-acetylcysteine; reactive oxygen species; hepatocellular carcinoma; dimethylbenzanthracene; cytochrome P450; days postfertilization; green fluorescent protein; unfolded protein response; alcoholic liver disease; endoplasmic reticulum

As the incidence of hepatobiliary diseases increases, we must improve our understanding of the molecular, cellular, and physiological factors that contribute to the pathogenesis of liver disease. Animal models help us identify disease mechanisms that might be targeted therapeutically. Zebrafish (Dan...