Zebrafish: An Important Tool for Liver Disease Research

As the incidence of hepatobiliary diseases increases, we must improve our understanding of the molecular, cellular, and physiological factors that contribute to the pathogenesis of liver disease. Animal models help us identify disease mechanisms that might be targeted therapeutically. Zebrafish (Dan...

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Published inGastroenterology (New York, N.Y. 1943) Vol. 149; no. 6; pp. 1361 - 1377
Main Authors Goessling, Wolfram, Sadler, Kirsten C.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.11.2015
Subjects
Animals
Development
Disease Models, Animal
Gastroenterology and Hepatology
Humans
Liver - metabolism
Liver - pathology
Liver - physiopathology
Liver Cancer
Liver Diseases - genetics
Liver Diseases - metabolism
Liver Diseases - pathology
Liver Diseases - physiopathology
Regeneration
Technology
Toxicology
Zebrafish - genetics
Zebrafish - growth & development
Zebrafish - metabolism
DILI
DMBA
HCC
Liver Cancer
ER
GFP
Regeneration
NAC
Toxicology
Technology
UPR
ROS
Development
ALD
CYP
dpf
FLD
drug-induced liver injury
fatty liver disease
N-acetylcysteine
reactive oxygen species
hepatocellular carcinoma
dimethylbenzanthracene
cytochrome P450
days postfertilization
green fluorescent protein
unfolded protein response
alcoholic liver disease
endoplasmic reticulum
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Abstract As the incidence of hepatobiliary diseases increases, we must improve our understanding of the molecular, cellular, and physiological factors that contribute to the pathogenesis of liver disease. Animal models help us identify disease mechanisms that might be targeted therapeutically. Zebrafish (Danio rerio) have traditionally been used to study embryonic development but are also important to the study of liver disease. Zebrafish embryos develop rapidly; all of their digestive organs are mature in larvae by 5 days of age. At this stage, they can develop hepatobiliary diseases caused by developmental defects or toxin- or ethanol-induced injury and manifest premalignant changes within weeks. Zebrafish are similar to humans in hepatic cellular composition, function, signaling, and response to injury as well as the cellular processes that mediate liver diseases. Genes are highly conserved between humans and zebrafish, making them a useful system to study the basic mechanisms of liver disease. We can perform genetic screens to identify novel genes involved in specific disease processes and chemical screens to identify pathways and compounds that act on specific processes. We review how studies of zebrafish have advanced our understanding of inherited and acquired liver diseases as well as liver cancer and regeneration.
AbstractList As the incidence of hepatobiliary diseases increases, we must improve our understanding of the molecular, cellular, and physiological factors that contribute to the pathogenesis of liver disease. Animal models help us identify disease mechanisms that might be targeted therapeutically. Zebrafish (Danio rerio) have traditionally been used to study embryonic development but are also important to the study of liver disease. Zebrafish embryos develop rapidly; all of their digestive organs are mature in larvae by 5 days of age. At this stage, they can develop hepatobiliary diseases caused by developmental defects or toxin- or ethanol-induced injury and manifest premalignant changes within weeks. Zebrafish are similar to humans in hepatic cellular composition, function, signaling, and response to injury as well as the cellular processes that mediate liver diseases. Genes are highly conserved between humans and zebrafish, making them a useful system to study the basic mechanisms of liver disease. We can perform genetic screens to identify novel genes involved in specific disease processes and chemical screens to identify pathways and compounds that act on specific processes. We review how studies of zebrafish have advanced our understanding of inherited and acquired liver diseases as well as liver cancer and regeneration.
As the incidence of hepatobiliary diseases increases, we must improve our understanding of the molecular, cellular, and physiological factors that contribute to the pathogenesis of liver disease. Animal models help us identify disease mechanisms that might be targeted therapeutically. Zebrafish ( Danio rerio ) have traditionally been used to study embryonic development but are also important to the study of liver disease. Zebrafish embryos develop rapidly; all of their digestive organs are mature in larvae by 5 days of age. At this stage, they can develop hepatobiliary diseases caused by developmental defects or toxin- or ethanol-induced injury and manifest premalignant changes within weeks. Zebrafish are similar to humans in hepatic cellular composition, function, signaling, and response to injury as well as the cellular processes that mediate liver diseases. Genes are highly conserved between humans and zebrafish, making them a useful system to study the basic mechanisms of liver disease. We can perform genetic screens to identify novel genes involved in specific disease processes and chemical screens to identify pathways and compounds that act on specific processes. We review how studies of zebrafish have advanced our understanding of inherited and acquired liver diseases as well as liver cancer and regeneration.
As the incidence of hepatobiliary diseases increases, we must improve our understanding of the molecular, cellular, and physiological factors that contribute to the pathogenesis of liver disease. Animal models help us identify disease mechanisms that might be targeted therapeutically. Zebrafish (Danio rerio) have traditionally been used to study embryonic development but are also important to the study of liver disease. Zebrafish embryos develop rapidly; all of their digestive organs are mature in larvae by 5 days of age. At this stage, they can develop hepatobiliary diseases caused by developmental defects or toxin- or ethanol-induced injury and manifest premalignant changes within weeks. Zebrafish are similar to humans in hepatic cellular composition, function, signaling, and response to injury as well as the cellular processes that mediate liver diseases. Genes are highly conserved between humans and zebrafish, making them a useful system to study the basic mechanisms of liver disease. We can perform genetic screens to identify novel genes involved in specific disease processes and chemical screens to identify pathways and compounds that act on specific processes. We review how studies of zebrafish have advanced our understanding of inherited and acquired liver diseases as well as liver cancer and regeneration.As the incidence of hepatobiliary diseases increases, we must improve our understanding of the molecular, cellular, and physiological factors that contribute to the pathogenesis of liver disease. Animal models help us identify disease mechanisms that might be targeted therapeutically. Zebrafish (Danio rerio) have traditionally been used to study embryonic development but are also important to the study of liver disease. Zebrafish embryos develop rapidly; all of their digestive organs are mature in larvae by 5 days of age. At this stage, they can develop hepatobiliary diseases caused by developmental defects or toxin- or ethanol-induced injury and manifest premalignant changes within weeks. Zebrafish are similar to humans in hepatic cellular composition, function, signaling, and response to injury as well as the cellular processes that mediate liver diseases. Genes are highly conserved between humans and zebrafish, making them a useful system to study the basic mechanisms of liver disease. We can perform genetic screens to identify novel genes involved in specific disease processes and chemical screens to identify pathways and compounds that act on specific processes. We review how studies of zebrafish have advanced our understanding of inherited and acquired liver diseases as well as liver cancer and regeneration.
Author Sadler, Kirsten C.
Goessling, Wolfram
AuthorAffiliation 2 Gastrointestinal Cancer Center, Dana-Farber Cancer Institute, Boston, Massachusetts
4 Broad Institute of MIT and Harvard, Harvard Medical School, Boston, Massachusetts
1 Divisions of Genetics and Gastroenterology, Brigham and Women’s Hospital, Boston, Massachusetts
3 Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts
6 Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York
5 Department of Medicine, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, New York
7 Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York
AuthorAffiliation_xml – name: 6 Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York
– name: 5 Department of Medicine, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, New York
– name: 3 Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts
– name: 7 Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York
– name: 2 Gastrointestinal Cancer Center, Dana-Farber Cancer Institute, Boston, Massachusetts
– name: 4 Broad Institute of MIT and Harvard, Harvard Medical School, Boston, Massachusetts
– name: 1 Divisions of Genetics and Gastroenterology, Brigham and Women’s Hospital, Boston, Massachusetts
Author_xml – sequence: 1
  givenname: Wolfram
  surname: Goessling
  fullname: Goessling, Wolfram
  organization: Divisions of Genetics and Gastroenterology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts
– sequence: 2
  givenname: Kirsten C.
  surname: Sadler
  fullname: Sadler, Kirsten C.
  email: kirsten.edepli@nyu.edu
  organization: Department of Medicine, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, New York
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26319012$$D View this record in MEDLINE/PubMed
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1528-0012
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Issue 6
Keywords DILI
DMBA
HCC
Liver Cancer
ER
GFP
Regeneration
NAC
Toxicology
Technology
UPR
ROS
Development
ALD
CYP
dpf
FLD
drug-induced liver injury
fatty liver disease
N-acetylcysteine
reactive oxygen species
hepatocellular carcinoma
dimethylbenzanthracene
cytochrome P450
days postfertilization
green fluorescent protein
unfolded protein response
alcoholic liver disease
endoplasmic reticulum
Language English
License Copyright © 2015 AGA Institute. Published by Elsevier Inc. All rights reserved.
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content type line 23
Kirsten C. Sadler’s current affiliation is: Biology Program, New York University, Saadiyat Campus, P.O. Box 129188 Abu Dhabi, United Arab Emirates kirsten.edepli@nyu.edu
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PublicationTitle Gastroenterology (New York, N.Y. 1943)
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Snippet As the incidence of hepatobiliary diseases increases, we must improve our understanding of the molecular, cellular, and physiological factors that contribute...
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SubjectTerms Animals
Development
Disease Models, Animal
Gastroenterology and Hepatology
Humans
Liver - metabolism
Liver - pathology
Liver - physiopathology
Liver Cancer
Liver Diseases - genetics
Liver Diseases - metabolism
Liver Diseases - pathology
Liver Diseases - physiopathology
Regeneration
Technology
Toxicology
Zebrafish - genetics
Zebrafish - growth & development
Zebrafish - metabolism
Title Zebrafish: An Important Tool for Liver Disease Research
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https://www.clinicalkey.es/playcontent/1-s2.0-S0016508515012020
https://dx.doi.org/10.1053/j.gastro.2015.08.034
https://www.ncbi.nlm.nih.gov/pubmed/26319012
https://www.proquest.com/docview/1728669688
https://pubmed.ncbi.nlm.nih.gov/PMC4762709
Volume 149
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