Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance

• Published in: The Journal of clinical investigation Vol. 123; no. 12; pp. 5269 - 5283
• Main Authors: Liu, Shu-Chen, Tsang, Ngan-Ming, Chiang, Wen-Che, Chang, Kai-Ping, Hsueh, Chuen, Liang, Ying, Juang, Jyh-Lyh, Chow, Kai-Ping N., Chang, Yu-Sun
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.12.2013
• Subjects: Animals; Apoptosis; Biomedical research; Carcinoma - blood; Carcinoma - pathology; Carcinoma - radiotherapy; Cytokines; Deoxyribonucleic acid; Development and progression; Disease Progression; DNA; DNA Damage; DNA repair; Gamma Rays; Gene Expression Regulation, Viral; Heterografts; Humans; Leukemia; Leukemia Inhibitory Factor - antagonists & inhibitors; Leukemia Inhibitory Factor - blood; Leukemia Inhibitory Factor - physiology; Mechanistic Target of Rapamycin Complex 1; Medical prognosis; Mice; Mice, Inbred NOD; Mice, SCID; Multiprotein Complexes - physiology; Nasopharyngeal cancer; Nasopharyngeal Neoplasms - blood; Nasopharyngeal Neoplasms - pathology; Nasopharyngeal Neoplasms - radiotherapy; Neoplasm Proteins - antagonists & inhibitors; Neoplasm Proteins - blood; Neoplasm Proteins - physiology; Neoplasm Recurrence, Local - blood; Prognosis; Radiation Tolerance; Radiotherapy; Receptors, OSM-LIF; Ribosomal Protein S6 Kinases, 70-kDa - physiology; Signal Transduction - physiology; Sirolimus - pharmacology; TOR Serine-Threonine Kinases - physiology; Tumor Cells, Cultured; Tumor Microenvironment; Tumors; Viral Matrix Proteins - physiology; Taiwan

Radioresistance of EBV-associated nasopharyngeal carcinoma (NPC) is associated with poor prognosis for patients with this form of cancer. Here, we found that NPC patients had increased serum levels of leukemia inhibitory factor (LIF) and that higher LIF levels correlated with local tumor recurrence....