Vaccination with short-term-cultured autologous PBMCs efficiently activated STLV-1-specific CTLs in naturally STLV-1-infected Japanese monkeys with impaired CTL responses

• Published in: PLoS pathogens Vol. 19; no. 2; p. e1011104
• Main Authors: Hasegawa, Atsuhiko, Murata, Megumi, Fujikawa, Tomoka, Katagiri, Kuniko, Nagano, Yoshiko, Masuda, Takao, Kuramitsu, Madoka, Nakajima, Shinsuke, Fujisawa, Jun-ichi, Okuma, Kazu, Grover, Poonam, Kidiga, Maureen, Akari, Hirofumi, Kannagi, Mari
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 02.02.2023; Public Library of Science (PLoS)
• Subjects: Animals; Antigens; Asymptomatic; Biology and Life Sciences; Chemotherapy; Cytotoxicity; Dendritic cells; Disease; Epitopes; Flow cytometry; Host-virus relationships; HTLV-I infections; Human T-lymphotropic virus 1; Humans; Immune response; Immunization; Immunoproliferative diseases; In vivo methods and tests; Infections; Leukemia; Leukemia-Lymphoma, Adult T-Cell; Leukocytes, Mononuclear; Lymphocytes; Lymphocytes T; Lymphoma; Macaca fuscata; Medicine and Health Sciences; Mitomycin C; Monkeys; Monkeys & apes; Monoclonal antibodies; Observations; Patients; Peptides; Peripheral blood mononuclear cells; Prevention; Proviruses; Reduction; Research and Analysis Methods; Simian T-lymphotropic virus 1; T-Lymphocytes, Cytotoxic; Testing; Tumor necrosis factor-TNF; Vaccination; Vaccines; Viral envelope proteins; Viruses; Japan

A small proportion of human T-cell leukemia virus type-1 (HTLV-1)-infected individuals develop adult T-cell leukemia/lymphoma, a chemotherapy-resistant lymphoproliferative disease with a poor prognosis. HTLV-1-specific cytotoxic T lymphocytes (CTLs), potential anti-tumor/virus effectors, are impaire...