Vaccination with short-term-cultured autologous PBMCs efficiently activated STLV-1-specific CTLs in naturally STLV-1-infected Japanese monkeys with impaired CTL responses

A small proportion of human T-cell leukemia virus type-1 (HTLV-1)-infected individuals develop adult T-cell leukemia/lymphoma, a chemotherapy-resistant lymphoproliferative disease with a poor prognosis. HTLV-1-specific cytotoxic T lymphocytes (CTLs), potential anti-tumor/virus effectors, are impaire...

Full description

Saved in:
Bibliographic Details
Published inPLoS pathogens Vol. 19; no. 2; p. e1011104
Main Authors Hasegawa, Atsuhiko, Murata, Megumi, Fujikawa, Tomoka, Katagiri, Kuniko, Nagano, Yoshiko, Masuda, Takao, Kuramitsu, Madoka, Nakajima, Shinsuke, Fujisawa, Jun-ichi, Okuma, Kazu, Grover, Poonam, Kidiga, Maureen, Akari, Hirofumi, Kannagi, Mari
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 02.02.2023
Public Library of Science (PLoS)
Subjects
Animals
Antigens
Asymptomatic
Biology and Life Sciences
Chemotherapy
Cytotoxicity
Dendritic cells
Disease
Epitopes
Flow cytometry
Host-virus relationships
HTLV-I infections
Human T-lymphotropic virus 1
Humans
Immune response
Immunization
Immunoproliferative diseases
In vivo methods and tests
Infections
Leukemia
Leukemia-Lymphoma, Adult T-Cell
Leukocytes, Mononuclear
Lymphocytes
Lymphocytes T
Lymphoma
Macaca fuscata
Medicine and Health Sciences
Mitomycin C
Monkeys
Monkeys & apes
Monoclonal antibodies
Observations
Patients
Peptides
Peripheral blood mononuclear cells
Prevention
Proviruses
Reduction
Research and Analysis Methods
Simian T-lymphotropic virus 1
T-Lymphocytes, Cytotoxic
Testing
Tumor necrosis factor-TNF
Vaccination
Vaccines
Viral envelope proteins
Viruses
Japan
Online AccessGet full text

Cover

Abstract A small proportion of human T-cell leukemia virus type-1 (HTLV-1)-infected individuals develop adult T-cell leukemia/lymphoma, a chemotherapy-resistant lymphoproliferative disease with a poor prognosis. HTLV-1-specific cytotoxic T lymphocytes (CTLs), potential anti-tumor/virus effectors, are impaired in adult T-cell leukemia/lymphoma patients. Here, using Japanese monkeys naturally infected with simian T-cell leukemia/T-lymphotropic virus type-1 (STLV-1) as a model, we demonstrate that short-term-cultured autologous peripheral blood mononuclear cells (PBMCs) can serve as a therapeutic vaccine to activate such CTLs. In a screening test, STLV-1-specific CTL activity was detectable in 8/10 naturally STLV-1-infected monkeys. We conducted a vaccine study in the remaining two monkeys with impaired CTL responses. The short-term-cultured PBMCs of these monkeys spontaneously expressed viral antigens, in a similar way to PBMCs from human HTLV-1 carriers. The first monkey was subcutaneously inoculated with three-day-cultured and mitomycin C (MMC)-treated autologous PBMCs, and then boosted with MMC-treated autologous STLV-1-infected cell line cells. The second monkey was inoculated with autologous PBMC-vaccine alone twice. In addition, a third monkey that originally showed a weak STLV-1-specific CTL response was inoculated with similar autologous PBMC-vaccines. In all three vaccinated monkeys, marked activation of STLV-1-specific CTLs and a mild reduction in the STLV-1 proviral load were observed. Follow-up analyses on the two monkeys vaccinated with PBMCs alone indicated that STLV-1-specific CTL responses peaked at 3–4 months after vaccination, and then diminished but remained detectable for more than one year. The significant reduction in the proviral load and the control of viral expression were associated with CTL activation but also diminished 6 and 12 months after vaccination, respectively, suggesting the requirement for a booster. The vaccine-induced CTLs in these monkeys recognized epitopes in the STLV-1 Tax and/or Envelope proteins, and efficiently killed autologous STLV-1-infected cells in vitro . These findings indicated that the autologous PBMC-based vaccine could induce functional STLV-1-specific CTLs in vivo .
AbstractList A small proportion of human T-cell leukemia virus type-1 (HTLV-1)-infected individuals develop adult T-cell leukemia/lymphoma, a chemotherapy-resistant lymphoproliferative disease with a poor prognosis. HTLV-1-specific cytotoxic T lymphocytes (CTLs), potential anti-tumor/virus effectors, are impaired in adult T-cell leukemia/lymphoma patients. Here, using Japanese monkeys naturally infected with simian T-cell leukemia/T-lymphotropic virus type-1 (STLV-1) as a model, we demonstrate that short-term-cultured autologous peripheral blood mononuclear cells (PBMCs) can serve as a therapeutic vaccine to activate such CTLs. In a screening test, STLV-1-specific CTL activity was detectable in 8/10 naturally STLV-1-infected monkeys. We conducted a vaccine study in the remaining two monkeys with impaired CTL responses. The short-term-cultured PBMCs of these monkeys spontaneously expressed viral antigens, in a similar way to PBMCs from human HTLV-1 carriers. The first monkey was subcutaneously inoculated with three-day-cultured and mitomycin C (MMC)-treated autologous PBMCs, and then boosted with MMC-treated autologous STLV-1-infected cell line cells. The second monkey was inoculated with autologous PBMC-vaccine alone twice. In addition, a third monkey that originally showed a weak STLV-1-specific CTL response was inoculated with similar autologous PBMC-vaccines. In all three vaccinated monkeys, marked activation of STLV-1-specific CTLs and a mild reduction in the STLV-1 proviral load were observed. Follow-up analyses on the two monkeys vaccinated with PBMCs alone indicated that STLV-1-specific CTL responses peaked at 3-4 months after vaccination, and then diminished but remained detectable for more than one year. The significant reduction in the proviral load and the control of viral expression were associated with CTL activation but also diminished 6 and 12 months after vaccination, respectively, suggesting the requirement for a booster. The vaccine-induced CTLs in these monkeys recognized epitopes in the STLV-1 Tax and/or Envelope proteins, and efficiently killed autologous STLV-1-infected cells in vitro. These findings indicated that the autologous PBMC-based vaccine could induce functional STLV-1-specific CTLs in vivo.
A small proportion of human T-cell leukemia virus type-1 (HTLV-1)-infected individuals develop adult T-cell leukemia/lymphoma, a chemotherapy-resistant lymphoproliferative disease with a poor prognosis. HTLV-1-specific cytotoxic T lymphocytes (CTLs), potential anti-tumor/virus effectors, are impaired in adult T-cell leukemia/lymphoma patients. Here, using Japanese monkeys naturally infected with simian T-cell leukemia/T-lymphotropic virus type-1 (STLV-1) as a model, we demonstrate that short-term-cultured autologous peripheral blood mononuclear cells (PBMCs) can serve as a therapeutic vaccine to activate such CTLs. In a screening test, STLV-1-specific CTL activity was detectable in 8/10 naturally STLV-1-infected monkeys. We conducted a vaccine study in the remaining two monkeys with impaired CTL responses. The short-term-cultured PBMCs of these monkeys spontaneously expressed viral antigens, in a similar way to PBMCs from human HTLV-1 carriers. The first monkey was subcutaneously inoculated with three-day-cultured and mitomycin C (MMC)-treated autologous PBMCs, and then boosted with MMC-treated autologous STLV-1-infected cell line cells. The second monkey was inoculated with autologous PBMC-vaccine alone twice. In addition, a third monkey that originally showed a weak STLV-1-specific CTL response was inoculated with similar autologous PBMC-vaccines. In all three vaccinated monkeys, marked activation of STLV-1-specific CTLs and a mild reduction in the STLV-1 proviral load were observed. Follow-up analyses on the two monkeys vaccinated with PBMCs alone indicated that STLV-1-specific CTL responses peaked at 3-4 months after vaccination, and then diminished but remained detectable for more than one year. The significant reduction in the proviral load and the control of viral expression were associated with CTL activation but also diminished 6 and 12 months after vaccination, respectively, suggesting the requirement for a booster. The vaccine-induced CTLs in these monkeys recognized epitopes in the STLV-1 Tax and/or Envelope proteins, and efficiently killed autologous STLV-1-infected cells in vitro. These findings indicated that the autologous PBMC-based vaccine could induce functional STLV-1-specific CTLs in vivo.A small proportion of human T-cell leukemia virus type-1 (HTLV-1)-infected individuals develop adult T-cell leukemia/lymphoma, a chemotherapy-resistant lymphoproliferative disease with a poor prognosis. HTLV-1-specific cytotoxic T lymphocytes (CTLs), potential anti-tumor/virus effectors, are impaired in adult T-cell leukemia/lymphoma patients. Here, using Japanese monkeys naturally infected with simian T-cell leukemia/T-lymphotropic virus type-1 (STLV-1) as a model, we demonstrate that short-term-cultured autologous peripheral blood mononuclear cells (PBMCs) can serve as a therapeutic vaccine to activate such CTLs. In a screening test, STLV-1-specific CTL activity was detectable in 8/10 naturally STLV-1-infected monkeys. We conducted a vaccine study in the remaining two monkeys with impaired CTL responses. The short-term-cultured PBMCs of these monkeys spontaneously expressed viral antigens, in a similar way to PBMCs from human HTLV-1 carriers. The first monkey was subcutaneously inoculated with three-day-cultured and mitomycin C (MMC)-treated autologous PBMCs, and then boosted with MMC-treated autologous STLV-1-infected cell line cells. The second monkey was inoculated with autologous PBMC-vaccine alone twice. In addition, a third monkey that originally showed a weak STLV-1-specific CTL response was inoculated with similar autologous PBMC-vaccines. In all three vaccinated monkeys, marked activation of STLV-1-specific CTLs and a mild reduction in the STLV-1 proviral load were observed. Follow-up analyses on the two monkeys vaccinated with PBMCs alone indicated that STLV-1-specific CTL responses peaked at 3-4 months after vaccination, and then diminished but remained detectable for more than one year. The significant reduction in the proviral load and the control of viral expression were associated with CTL activation but also diminished 6 and 12 months after vaccination, respectively, suggesting the requirement for a booster. The vaccine-induced CTLs in these monkeys recognized epitopes in the STLV-1 Tax and/or Envelope proteins, and efficiently killed autologous STLV-1-infected cells in vitro. These findings indicated that the autologous PBMC-based vaccine could induce functional STLV-1-specific CTLs in vivo.
A small proportion of human T-cell leukemia virus type-1 (HTLV-1)-infected individuals develop adult T-cell leukemia/lymphoma, a chemotherapy-resistant lymphoproliferative disease with a poor prognosis. HTLV-1-specific cytotoxic T lymphocytes (CTLs), potential anti-tumor/virus effectors, are impaired in adult T-cell leukemia/lymphoma patients. Here, using Japanese monkeys naturally infected with simian T-cell leukemia/T-lymphotropic virus type-1 (STLV-1) as a model, we demonstrate that short-term-cultured autologous peripheral blood mononuclear cells (PBMCs) can serve as a therapeutic vaccine to activate such CTLs. In a screening test, STLV-1-specific CTL activity was detectable in 8/10 naturally STLV-1-infected monkeys. We conducted a vaccine study in the remaining two monkeys with impaired CTL responses. The short-term-cultured PBMCs of these monkeys spontaneously expressed viral antigens, in a similar way to PBMCs from human HTLV-1 carriers. The first monkey was subcutaneously inoculated with three-day-cultured and mitomycin C (MMC)-treated autologous PBMCs, and then boosted with MMC-treated autologous STLV-1-infected cell line cells. The second monkey was inoculated with autologous PBMC-vaccine alone twice. In addition, a third monkey that originally showed a weak STLV-1-specific CTL response was inoculated with similar autologous PBMC-vaccines. In all three vaccinated monkeys, marked activation of STLV-1-specific CTLs and a mild reduction in the STLV-1 proviral load were observed. Follow-up analyses on the two monkeys vaccinated with PBMCs alone indicated that STLV-1-specific CTL responses peaked at 3–4 months after vaccination, and then diminished but remained detectable for more than one year. The significant reduction in the proviral load and the control of viral expression were associated with CTL activation but also diminished 6 and 12 months after vaccination, respectively, suggesting the requirement for a booster. The vaccine-induced CTLs in these monkeys recognized epitopes in the STLV-1 Tax and/or Envelope proteins, and efficiently killed autologous STLV-1-infected cells in vitro . These findings indicated that the autologous PBMC-based vaccine could induce functional STLV-1-specific CTLs in vivo .
A small proportion of human T-cell leukemia virus type-1 (HTLV-1)-infected individuals develop adult T-cell leukemia/lymphoma, a chemotherapy-resistant lymphoproliferative disease with a poor prognosis. HTLV-1-specific cytotoxic T lymphocytes (CTLs), potential anti-tumor/virus effectors, are impaired in adult T-cell leukemia/lymphoma patients. Here, using Japanese monkeys naturally infected with simian T-cell leukemia/T-lymphotropic virus type-1 (STLV-1) as a model, we demonstrate that short-term-cultured autologous peripheral blood mononuclear cells (PBMCs) can serve as a therapeutic vaccine to activate such CTLs. In a screening test, STLV-1-specific CTL activity was detectable in 8/10 naturally STLV-1-infected monkeys. We conducted a vaccine study in the remaining two monkeys with impaired CTL responses. The short-term-cultured PBMCs of these monkeys spontaneously expressed viral antigens, in a similar way to PBMCs from human HTLV-1 carriers. The first monkey was subcutaneously inoculated with three-day-cultured and mitomycin C (MMC)-treated autologous PBMCs, and then boosted with MMC-treated autologous STLV-1-infected cell line cells. The second monkey was inoculated with autologous PBMC-vaccine alone twice. In addition, a third monkey that originally showed a weak STLV-1-specific CTL response was inoculated with similar autologous PBMC-vaccines. In all three vaccinated monkeys, marked activation of STLV-1-specific CTLs and a mild reduction in the STLV-1 proviral load were observed. Follow-up analyses on the two monkeys vaccinated with PBMCs alone indicated that STLV-1-specific CTL responses peaked at 3–4 months after vaccination, and then diminished but remained detectable for more than one year. The significant reduction in the proviral load and the control of viral expression were associated with CTL activation but also diminished 6 and 12 months after vaccination, respectively, suggesting the requirement for a booster. The vaccine-induced CTLs in these monkeys recognized epitopes in the STLV-1 Tax and/or Envelope proteins, and efficiently killed autologous STLV-1-infected cells in vitro . These findings indicated that the autologous PBMC-based vaccine could induce functional STLV-1-specific CTLs in vivo . Human T-cell leukemia virus type-1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL) in a small proportion of infected individuals. ATL patients exhibit impaired HTLV-1-specific cytotoxic T-lymphocyte (CTL) responses, even in the early stages of the disease. Activation of these CTLs may induce anti-ATL effects, as suggested by the favorable clinical outcomes in a recent clinical study of a Tax peptide-pulsed dendritic cell vaccine in ATL patients with limited HLA alleles. Paradoxically, HTLV-1 expression is extremely low in vivo , where Tax is undetectable by serological means. These findings imply that HTLV-1 expression in vivo may be too scarce to restore the impaired CTLs but could be recognized by CTLs once they are activated. Notably, short-term culture of peripheral blood mononuclear cells (PBMCs) from HTLV-1-infected individuals induces viral antigens and can activate antigen-presenting cells. In the present study, using Japanese monkeys that were naturally infected with simian T-cell leukemia/T-lymphotropic virus type-1 (STLV-1) closely related to HTLV-1, we demonstrated that vaccination with short-term-cultured autologous PBMCs evoked functional STLV-1-specific CTL responses in the subgroup of monkeys that originally exhibited impaired STLV-1-specific CTL activities. These results imply that short-term-cultured autologous PBMCs could act as an anti-ATL vaccine, without being limited by HLA.
Audience Academic
Author Masuda, Takao
Murata, Megumi
Nagano, Yoshiko
Fujikawa, Tomoka
Katagiri, Kuniko
Grover, Poonam
Fujisawa, Jun-ichi
Kannagi, Mari
Kuramitsu, Madoka
Okuma, Kazu
Nakajima, Shinsuke
Akari, Hirofumi
Hasegawa, Atsuhiko
Kidiga, Maureen
AuthorAffiliation 2 Cancer Cell Biology Laboratory, Department of Cancer Biology, Clinical Research Institute, National Hospital Organization, Kyushu Cancer Center, Fukuoka, Japan
4 Research Center for Biological Products in the Next Generation, National Institute of Infectious Diseases, Tokyo, Japan
5 Department of Microbiology, Kansai Medical University, Osaka, Japan
3 Center for the Evolutionary Origins of Human Behavior, Kyoto University, Kyoto, Japan
Imperial College London, UNITED KINGDOM
1 Deparment of Immunotherapeutics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
AuthorAffiliation_xml – name: Imperial College London, UNITED KINGDOM
– name: 5 Department of Microbiology, Kansai Medical University, Osaka, Japan
– name: 4 Research Center for Biological Products in the Next Generation, National Institute of Infectious Diseases, Tokyo, Japan
– name: 2 Cancer Cell Biology Laboratory, Department of Cancer Biology, Clinical Research Institute, National Hospital Organization, Kyushu Cancer Center, Fukuoka, Japan
– name: 3 Center for the Evolutionary Origins of Human Behavior, Kyoto University, Kyoto, Japan
– name: 1 Deparment of Immunotherapeutics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
Author_xml – sequence: 1
  givenname: Atsuhiko
  surname: Hasegawa
  fullname: Hasegawa, Atsuhiko
– sequence: 2
  givenname: Megumi
  surname: Murata
  fullname: Murata, Megumi
– sequence: 3
  givenname: Tomoka
  surname: Fujikawa
  fullname: Fujikawa, Tomoka
– sequence: 4
  givenname: Kuniko
  surname: Katagiri
  fullname: Katagiri, Kuniko
– sequence: 5
  givenname: Yoshiko
  surname: Nagano
  fullname: Nagano, Yoshiko
– sequence: 6
  givenname: Takao
  surname: Masuda
  fullname: Masuda, Takao
– sequence: 7
  givenname: Madoka
  surname: Kuramitsu
  fullname: Kuramitsu, Madoka
– sequence: 8
  givenname: Shinsuke
  surname: Nakajima
  fullname: Nakajima, Shinsuke
– sequence: 9
  givenname: Jun-ichi
  surname: Fujisawa
  fullname: Fujisawa, Jun-ichi
– sequence: 10
  givenname: Kazu
  surname: Okuma
  fullname: Okuma, Kazu
– sequence: 11
  givenname: Poonam
  surname: Grover
  fullname: Grover, Poonam
– sequence: 12
  givenname: Maureen
  surname: Kidiga
  fullname: Kidiga, Maureen
– sequence: 13
  givenname: Hirofumi
  surname: Akari
  fullname: Akari, Hirofumi
– sequence: 14
  givenname: Mari
  orcidid: 0000-0002-3433-2658
  surname: Kannagi
  fullname: Kannagi, Mari
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36730466$$D View this record in MEDLINE/PubMed
BookMark eNqVk9uO0zAQhiO0iD3AGyAUiRu4SLFjN064WGmpOBSVg9iyt5brTFqXJA62s9BX4imZbLvLdoWQUC6S2N__j2fGcxwdtLaFKHpMyYgyQV-sbe9aVY-6ToURJZRSwu9FR3Q8Zolggh_c-j6Mjr1fE8Ipo9mD6JBlghGeZUfRrwultWlVMLaNf5iwiv3KupAEcE2i-zr0DspY9cHWdml7H39-9WHiY6gqow20od7ESgdzqQJi5_PZRUIT34E2uB9P5jMfmzZG-96pGtkdYdoK9KB4rzrVgoe4se032PjtEUzTKTPERYPYge9s68E_jO5XqvbwaPc-ib6-eT2fvEtmn95OJ2ezRGdMBMyXA1ULrcsyp5SXYlFVNMvHUHGSsxL_BVAhxqCYAAUiHeepFkWaEijSQhXsJJpufUur1rJzplFuI60y8mrBuqVULhhdg2RqkXOSDhYFp2KBoaoiK6mgepypjKHX6dar6xcNlBorhoXYM93fac1KLu2lLIo0pyxFg2c7A2e_9-CDbIzXUNdYNmyHTIVgNKUF4Yg-vYPurshA5SLDphPxh1oqTAAbYTGuHkzlmWAFJzwvhnOP_kLhU0JjNF7EyuD6nuD5ngCZAD_DUvXey-n5l_9gP-6zT24X8KZy1zcYAb4FtLPeO6huEErkMCjXVZDDoMjdoKDs5R2ZNuFqCjBRU_9b_BtAEh0E
CitedBy_id crossref_primary_10_1186_s12985_024_02434_7
crossref_primary_10_3390_ijms241411737
Cites_doi 10.1089/aid.1998.14.785
10.1093/jnci/93.23.1775
10.1038/srep27150
10.1111/cas.13948
10.1002/ijc.2910370107
10.1128/JVI.72.9.7289-7293.1998
10.1146/annurev-immunol-041015-055318
10.1371/journal.ppat.1006722
10.1089/aid.1992.8.1653
10.1128/JVI.00281-16
10.1093/intimm/3.8.761
10.1038/348245a0
10.1128/JVI.75.13.5939-5948.2001
10.1016/0042-6822(86)90336-3
10.1128/JVI.74.20.9610-9616.2000
10.1128/jvi.64.3.1278-1282.1990
10.1002/ijc.2910400320
10.1006/viro.1994.1097
10.1002/jmv.20807
10.1080/13550280490521104
10.1111/j.1600-065X.2011.01017.x
10.1016/S0165-5728(99)00175-7
10.1002/ijc.2910470403
10.1186/s12977-020-00525-1
10.1177/030098588201907s09
10.1111/bjh.13302
10.1086/420832
10.1016/S0140-6736(85)92734-5
10.1099/0022-1317-78-1-147
10.1016/j.humimm.2011.07.308
10.1002/ijc.2910400219
10.1186/1742-4690-10-118
10.1186/1742-4690-8-100
10.1111/cas.14800
10.1002/ijc.2910430214
10.1089/aid.2010.0082
10.1002/ajp.20043
10.1189/jlb.0309172
10.1128/JVI.77.5.2956-2963.2003
10.1016/S0140-6736(86)91298-5
10.1016/j.virol.2006.12.020
10.1186/s12977-019-0503-0
10.1182/blood-2010-11-316463
10.1186/s12977-019-0484-z
10.1128/JVI.00230-06
10.1099/vir.0.80766-0
10.1182/blood.V50.3.481.481
10.1084/jem.177.6.1567
10.1111/cas.13654
10.1016/j.jim.2006.03.013
ContentType Journal Article
Copyright Copyright: © 2023 Hasegawa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
COPYRIGHT 2023 Public Library of Science
2023 Hasegawa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2023 Hasegawa et al 2023 Hasegawa et al
Copyright_xml – notice: Copyright: © 2023 Hasegawa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
– notice: COPYRIGHT 2023 Public Library of Science
– notice: 2023 Hasegawa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2023 Hasegawa et al 2023 Hasegawa et al
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
ISN
ISR
3V.
7QL
7U9
7X7
7XB
88E
8FE
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
C1K
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
7X8
5PM
DOA
DOI 10.1371/journal.ppat.1011104
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Gale In Context: Canada
Gale In Context: Science
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Virology and AIDS Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability (subscription)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Medical Database
Biological Science Database
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Health & Medical Research Collection
Biological Science Collection
AIDS and Cancer Research Abstracts
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE
MEDLINE - Academic

Publicly Available Content Database
CrossRef
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
DocumentTitleAlternate Autologous PBMC-vaccine restored STLV-1-specific CTLs in naturally infected monkeys
EISSN 1553-7374
ExternalDocumentID oai_doaj_org_article_3ab840225829417bbfff96d171c56a63
PMC9928132
A739404893
36730466
10_1371_journal_ppat_1011104
Genre Research Support, Non-U.S. Gov't
Journal Article
GeographicLocations Japan
GeographicLocations_xml – name: Japan
GrantInformation_xml – fundername: ;
  grantid: 19cm0106365h, 21cm0106386h
– fundername: ;
  grantid: Project Mirai Research Grants
– fundername: ;
  grantid: JP20K07512
GroupedDBID ---
123
29O
2WC
53G
5VS
7X7
88E
8FE
8FH
8FI
8FJ
AAFWJ
AAUCC
AAWOE
AAYXX
ABDBF
ABUWG
ACGFO
ACIHN
ACPRK
ACUHS
ADBBV
AEAQA
AENEX
AEUYN
AFKRA
AFPKN
AFRAH
AHMBA
ALMA_UNASSIGNED_HOLDINGS
AOIJS
B0M
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
BWKFM
CCPQU
CITATION
CS3
DIK
DU5
E3Z
EAP
EAS
EBD
EMK
EMOBN
ESX
F5P
FPL
FYUFA
GROUPED_DOAJ
GX1
HCIFZ
HMCUK
HYE
IAO
IHR
INH
INR
ISN
ISR
ITC
KQ8
LK8
M1P
M48
M7P
MM.
O5R
O5S
OK1
OVT
P2P
PGMZT
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PSQYO
PV9
QF4
QN7
RNS
RPM
RZL
SV3
TR2
TUS
UKHRP
WOW
~8M
ADRAZ
CGR
CUY
CVF
ECM
EIF
H13
IPNFZ
NPM
PJZUB
PPXIY
PQGLB
RIG
WOQ
PMFND
3V.
7QL
7U9
7XB
8FK
AZQEC
C1K
DWQXO
GNUQQ
H94
K9.
PKEHL
PQEST
PQUKI
7X8
5PM
PUEGO
ID FETCH-LOGICAL-c637t-734e1abccdd8114d7bff1685ef4083dd7b7e1775ea37eae72582c79220e929a93
IEDL.DBID 7X7
ISSN 1553-7374
1553-7366
IngestDate Wed Aug 27 01:32:13 EDT 2025
Thu Aug 21 18:38:05 EDT 2025
Wed Jul 30 11:11:32 EDT 2025
Fri Jul 25 11:56:58 EDT 2025
Tue Jun 17 21:42:50 EDT 2025
Tue Jun 10 20:25:06 EDT 2025
Fri Jun 27 06:10:39 EDT 2025
Fri Jun 27 05:25:33 EDT 2025
Mon Jul 21 05:58:43 EDT 2025
Tue Jul 01 03:47:55 EDT 2025
Thu Apr 24 22:57:51 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Language English
License Copyright: © 2023 Hasegawa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c637t-734e1abccdd8114d7bff1685ef4083dd7b7e1775ea37eae72582c79220e929a93
Notes new_version
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
The authors have declared that no competing interests exist.
ORCID 0000-0002-3433-2658
OpenAccessLink https://www.proquest.com/docview/2787636707?pq-origsite=%requestingapplication%
PMID 36730466
PQID 2787636707
PQPubID 1436335
PageCount e1011104
ParticipantIDs doaj_primary_oai_doaj_org_article_3ab840225829417bbfff96d171c56a63
pubmedcentral_primary_oai_pubmedcentral_nih_gov_9928132
proquest_miscellaneous_2773121904
proquest_journals_2787636707
gale_infotracmisc_A739404893
gale_infotracacademiconefile_A739404893
gale_incontextgauss_ISR_A739404893
gale_incontextgauss_ISN_A739404893
pubmed_primary_36730466
crossref_primary_10_1371_journal_ppat_1011104
crossref_citationtrail_10_1371_journal_ppat_1011104
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 20230202
PublicationDateYYYYMMDD 2023-02-02
PublicationDate_xml – month: 2
  year: 2023
  text: 20230202
  day: 2
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: San Francisco
– name: San Francisco, CA USA
PublicationTitle PLoS pathogens
PublicationTitleAlternate PLoS Pathog
PublicationYear 2023
Publisher Public Library of Science
Public Library of Science (PLoS)
Publisher_xml – name: Public Library of Science
– name: Public Library of Science (PLoS)
References T Kozako (ppat.1011104.ref018) 2011; 72
M Osame (ppat.1011104.ref003) 1986; 1
S Daenke (ppat.1011104.ref004) 1990; 64
M Ishizawa (ppat.1011104.ref026) 2021; 112
H Nakamura (ppat.1011104.ref051) 1987; 40
M Kazanji (ppat.1011104.ref053) 2006
K Ibuki (ppat.1011104.ref052) 1997; 78
R Furuta (ppat.1011104.ref056) 2017; 13
EL Murphy (ppat.1011104.ref013) 1989; 43
M Akimoto (ppat.1011104.ref043) 2007; 79
E Nerrienet (ppat.1011104.ref032) 1998; 14
K Mostoller (ppat.1011104.ref048) 2004; 10
Y Suehiro (ppat.1011104.ref020) 2015; 169
JM d’Offay (ppat.1011104.ref034) 2007; 57
I Elovaara (ppat.1011104.ref046) 1993; 177
T Watanabe (ppat.1011104.ref027) 1986; 148
A Gessain (ppat.1011104.ref002) 1985; 2
T Ohashi (ppat.1011104.ref008) 2000; 74
F Rende (ppat.1011104.ref025) 2011; 117
A Hasegawa (ppat.1011104.ref022) 2003; 77
M Kazanji (ppat.1011104.ref054) 2001; 75
PK Goon (ppat.1011104.ref047) 2004; 189
M Kannagi (ppat.1011104.ref021) 2019; 110
SL Manuel (ppat.1011104.ref050) 2009; 86
KJ Song (ppat.1011104.ref028) 1994; 199
M Kannagi (ppat.1011104.ref045) 1991; 3
K Komori (ppat.1011104.ref023) 2006; 80
NS Harhaj (ppat.1011104.ref049) 2007; 362
K Eguchi (ppat.1011104.ref035) 2011; 27
K Ishikawa (ppat.1011104.ref039) 1987; 40
B Asquith (ppat.1011104.ref042) 2005; 86
Y Tanaka (ppat.1011104.ref055) 1986; 37
M Murata (ppat.1011104.ref036) 2020; 17
H Kato (ppat.1011104.ref017) 1998; 72
S Hino (ppat.1011104.ref015) 1985; 76
T Uchiyama (ppat.1011104.ref001) 1977; 50
A Takamori (ppat.1011104.ref010) 2011; 8
R Kubota (ppat.1011104.ref041) 2000; 102
K Sugata (ppat.1011104.ref038) 2016; 6
CL Pond (ppat.1011104.ref044) 1982; 7
B Jegado (ppat.1011104.ref031) 2019; 16
T Kinoshita (ppat.1011104.ref005) 1991; 47
M Kannagi (ppat.1011104.ref007) 2019; 16
M Miura (ppat.1011104.ref040) 2013; 10
I Miyoshi (ppat.1011104.ref029) 1982; 73
K Kurihara (ppat.1011104.ref024) 2006; 313
J Mone (ppat.1011104.ref030) 1992; 8
LM McLane (ppat.1011104.ref012) 2019; 37
I Castro (ppat.1011104.ref037) 2016; 90
HL Weiner (ppat.1011104.ref011) 2011; 241
SW Parrish (ppat.1011104.ref033) 2004; 63
S Jacobson (ppat.1011104.ref006) 1990; 348
S Hanabuchi (ppat.1011104.ref009) 2001; 93
A Masaki (ppat.1011104.ref019) 2018; 109
C Bartholomew (ppat.1011104.ref014) 1998; 1
K Kinoshita (ppat.1011104.ref016) 1987; 78
References_xml – volume: 76
  start-page: 474
  issue: 6
  year: 1985
  ident: ppat.1011104.ref015
  article-title: Mother-to-child transmission of human T-cell leukemia virus type-I
  publication-title: Jpn J Cancer Res
– volume: 14
  start-page: 785
  issue: 9
  year: 1998
  ident: ppat.1011104.ref032
  article-title: Phylogenetic analysis of SIV and STLV type I in mandrills (Mandrillus sphinx): indications that intracolony transmissions are predominantly the result of male-to-male aggressive contacts
  publication-title: AIDS Res Hum Retroviruses
  doi: 10.1089/aid.1998.14.785
– volume: 93
  start-page: 1775
  issue: 23
  year: 2001
  ident: ppat.1011104.ref009
  article-title: Regression of human T-cell leukemia virus type I (HTLV-I)-associated lymphomas in a rat model: peptide-induced T-cell immunity
  publication-title: J Natl Cancer Inst
  doi: 10.1093/jnci/93.23.1775
– volume: 6
  start-page: 27150
  year: 2016
  ident: ppat.1011104.ref038
  article-title: Enhancement of anti-STLV-1/HTLV-1 immune responses through multimodal effects of anti-CCR4 antibody
  publication-title: Sci Rep
  doi: 10.1038/srep27150
– volume: 110
  start-page: 849
  issue: 3
  year: 2019
  ident: ppat.1011104.ref021
  article-title: Maintenance of long remission in adult T-cell leukemia by Tax-targeted vaccine: A hope for disease-preventive therapy
  publication-title: Cancer Sci
  doi: 10.1111/cas.13948
– volume: 37
  start-page: 35
  issue: 1
  year: 1986
  ident: ppat.1011104.ref055
  article-title: Antigens related to three core proteins of HTLV-I (p24, p19 and p15) and their intracellular localizations, as defined by monoclonal antibodies
  publication-title: Int J Cancer
  doi: 10.1002/ijc.2910370107
– volume: 72
  start-page: 7289
  issue: 9
  year: 1998
  ident: ppat.1011104.ref017
  article-title: Oral administration of human T-cell leukemia virus type 1 induces immune unresponsiveness with persistent infection in adult rats
  publication-title: J Virol
  doi: 10.1128/JVI.72.9.7289-7293.1998
– volume: 37
  start-page: 457
  year: 2019
  ident: ppat.1011104.ref012
  article-title: CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer
  publication-title: Annu Rev Immunol
  doi: 10.1146/annurev-immunol-041015-055318
– volume: 13
  start-page: e1006722
  issue: 11
  year: 2017
  ident: ppat.1011104.ref056
  article-title: Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1006722
– volume: 8
  start-page: 1653
  issue: 9
  year: 1992
  ident: ppat.1011104.ref030
  article-title: Simian T-cell leukemia virus type I infection in captive baboons
  publication-title: AIDS Res Hum Retroviruses
  doi: 10.1089/aid.1992.8.1653
– volume: 90
  start-page: 5280
  issue: 11
  year: 2016
  ident: ppat.1011104.ref037
  article-title: Cellular Immune Responses against Simian T-Lymphotropic Virus Type 1 Target Tax in Infected Baboons
  publication-title: J Virol
  doi: 10.1128/JVI.00281-16
– volume: 3
  start-page: 761
  issue: 8
  year: 1991
  ident: ppat.1011104.ref045
  article-title: Predominant recognition of human T cell leukemia virus type I (HTLV-I) pX gene products by human CD8+ cytotoxic T cells directed against HTLV-I-infected cells
  publication-title: Int Immunol
  doi: 10.1093/intimm/3.8.761
– start-page: 87
  year: 2006
  ident: ppat.1011104.ref053
  article-title: Chimeric peptide vaccine composed of B- and T-cell epitopes of human T-cell leukemia virus type 1 induces humoral and cellular immune responses and reduces the proviral load in immunized squirrel monkeys (Saimiri sciureus)
  publication-title: The Journal of general virology
– volume: 73
  start-page: 848
  issue: 6
  year: 1982
  ident: ppat.1011104.ref029
  article-title: Detection of type C virus particles in Japanese monkeys seropositive to adult T-cell leukemia-associated antigens.
  publication-title: Gan
– volume: 348
  start-page: 245
  issue: 6298
  year: 1990
  ident: ppat.1011104.ref006
  article-title: Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease
  publication-title: Nature
  doi: 10.1038/348245a0
– volume: 57
  start-page: 105
  issue: 1
  year: 2007
  ident: ppat.1011104.ref034
  article-title: Transmission dynamics of simian T-lymphotropic virus type 1 (STLV1) in a baboon breeding colony: predominance of female-to-female transmission
  publication-title: Comp Med
– volume: 75
  start-page: 5939
  issue: 13
  year: 2001
  ident: ppat.1011104.ref054
  article-title: Immunogenicity and protective efficacy of recombinant human T-cell leukemia/lymphoma virus type 1 NYVAC and naked DNA vaccine candidates in squirrel monkeys (Saimiri sciureus)
  publication-title: Journal of virology
  doi: 10.1128/JVI.75.13.5939-5948.2001
– volume: 78
  start-page: 674
  issue: 7
  year: 1987
  ident: ppat.1011104.ref016
  article-title: Milk-borne transmission of HTLV-I from carrier mothers to their children
  publication-title: Jpn J Cancer Res
– volume: 148
  start-page: 385
  issue: 2
  year: 1986
  ident: ppat.1011104.ref027
  article-title: Human T-cell leukemia virus type I is a member of the African subtype of simian viruses (STLV)
  publication-title: Virology
  doi: 10.1016/0042-6822(86)90336-3
– volume: 74
  start-page: 9610
  issue: 20
  year: 2000
  ident: ppat.1011104.ref008
  article-title: Prevention of adult T-cell leukemia-like lymphoproliferative disease in rats by adoptively transferred T cells from a donor immunized with human T-cell leukemia virus type 1 Tax-coding DNA vaccine
  publication-title: J Virol
  doi: 10.1128/JVI.74.20.9610-9616.2000
– volume: 64
  start-page: 1278
  issue: 3
  year: 1990
  ident: ppat.1011104.ref004
  article-title: Sequence variants of human T-cell lymphotropic virus type I from patients with tropical spastic paraparesis and adult T-cell leukemia do not distinguish neurological from leukemic isolates
  publication-title: J Virol
  doi: 10.1128/jvi.64.3.1278-1282.1990
– volume: 40
  start-page: 403
  issue: 3
  year: 1987
  ident: ppat.1011104.ref051
  article-title: Protection of cynomolgus monkeys against infection by human T-cell leukemia virus type-I by immunization with viral env gene products produced in Escherichia coli
  publication-title: Int J Cancer
  doi: 10.1002/ijc.2910400320
– volume: 199
  start-page: 56
  issue: 1
  year: 1994
  ident: ppat.1011104.ref028
  article-title: Genetic analysis and molecular phylogeny of simian T-cell lymphotropic virus type I: evidence for independent virus evolution in Asia and Africa
  publication-title: Virology
  doi: 10.1006/viro.1994.1097
– volume: 79
  start-page: 977
  issue: 7
  year: 2007
  ident: ppat.1011104.ref043
  article-title: Anti-HTLV-1 tax antibody and tax-specific cytotoxic T lymphocyte are associated with a reduction in HTLV-1 proviral load in asymptomatic carriers
  publication-title: J Med Virol
  doi: 10.1002/jmv.20807
– volume: 10
  start-page: 358
  issue: 6
  year: 2004
  ident: ppat.1011104.ref048
  article-title: Human T-cell leukemia virus type I Tax induces the expression of dendritic cell markers associated with maturation and activation
  publication-title: J Neurovirol
  doi: 10.1080/13550280490521104
– volume: 241
  start-page: 241
  issue: 1
  year: 2011
  ident: ppat.1011104.ref011
  article-title: Oral tolerance
  publication-title: Immunol Rev
  doi: 10.1111/j.1600-065X.2011.01017.x
– volume: 102
  start-page: 208
  issue: 2
  year: 2000
  ident: ppat.1011104.ref041
  article-title: HTLV-I specific IFN-gamma+ CD8+ lymphocytes correlate with the proviral load in peripheral blood of infected individuals
  publication-title: J Neuroimmunol
  doi: 10.1016/S0165-5728(99)00175-7
– volume: 47
  start-page: 491
  issue: 4
  year: 1991
  ident: ppat.1011104.ref005
  article-title: Sequence variations in LTR and env regions of HTLV-I do not discriminate between the virus from patients with HTLV-I-associated myelopathy and adult T-cell leukemia
  publication-title: Int J Cancer
  doi: 10.1002/ijc.2910470403
– volume: 17
  start-page: 15
  issue: 1
  year: 2020
  ident: ppat.1011104.ref036
  article-title: Frequent horizontal and mother-to-child transmission may contribute to high prevalence of STLV-1 infection in Japanese macaques
  publication-title: Retrovirology
  doi: 10.1186/s12977-020-00525-1
– volume: 7
  start-page: 126
  year: 1982
  ident: ppat.1011104.ref044
  article-title: Acute gastric dilatation in nonhuman primates: review and case studies
  publication-title: Vet Pathol Suppl
  doi: 10.1177/030098588201907s09
– volume: 169
  start-page: 356
  issue: 3
  year: 2015
  ident: ppat.1011104.ref020
  article-title: Clinical outcomes of a novel therapeutic vaccine with Tax peptide-pulsed dendritic cells for adult T cell leukaemia/lymphoma in a pilot study
  publication-title: Br J Haematol
  doi: 10.1111/bjh.13302
– volume: 189
  start-page: 2294
  issue: 12
  year: 2004
  ident: ppat.1011104.ref047
  article-title: Human T cell lymphotropic virus (HTLV) type-1-specific CD8+ T cells: frequency and immunodominance hierarchy
  publication-title: J Infect Dis
  doi: 10.1086/420832
– volume: 2
  start-page: 407
  issue: 8452
  year: 1985
  ident: ppat.1011104.ref002
  article-title: Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis
  publication-title: Lancet
  doi: 10.1016/S0140-6736(85)92734-5
– volume: 78
  start-page: 147
  year: 1997
  ident: ppat.1011104.ref052
  article-title: Long-term persistence of protective immunity in cynomolgus monkeys immunized with a recombinant vaccinia virus expressing the human T cell leukaemia virus type I envelope gene
  publication-title: J Gen Virol
  doi: 10.1099/0022-1317-78-1-147
– volume: 72
  start-page: 1001
  issue: 11
  year: 2011
  ident: ppat.1011104.ref018
  article-title: Programmed death-1 (PD-1)/PD-1 ligand pathway-mediated immune responses against human T-lymphotropic virus type 1 (HTLV-1) in HTLV-1-associated myelopathy/tropical spastic paraparesis and carriers with autoimmune disorders
  publication-title: Hum Immunol
  doi: 10.1016/j.humimm.2011.07.308
– volume: 40
  start-page: 233
  issue: 2
  year: 1987
  ident: ppat.1011104.ref039
  article-title: Serological survey and virus isolation of simian T-cell leukemia/T-lymphotropic virus type I (STLV-I) in non-human primates in their native countries
  publication-title: Int J Cancer
  doi: 10.1002/ijc.2910400219
– volume: 10
  start-page: 118
  year: 2013
  ident: ppat.1011104.ref040
  article-title: Characterization of simian T-cell leukemia virus type 1 in naturally infected Japanese macaques as a model of HTLV-1 infection
  publication-title: Retrovirology
  doi: 10.1186/1742-4690-10-118
– volume: 8
  start-page: 100
  year: 2011
  ident: ppat.1011104.ref010
  article-title: Functional impairment of Tax-specific but not cytomegalovirus-specific CD8+ T lymphocytes in a minor population of asymptomatic human T-cell leukemia virus type 1-carriers
  publication-title: Retrovirology
  doi: 10.1186/1742-4690-8-100
– volume: 112
  start-page: 1161
  issue: 3
  year: 2021
  ident: ppat.1011104.ref026
  article-title: Short-term cultured autologous peripheral blood mononuclear cells as a potential immunogen to activate Tax-specific CTL response in adult T-cell leukemia patients
  publication-title: Cancer Sci
  doi: 10.1111/cas.14800
– volume: 43
  start-page: 250
  issue: 2
  year: 1989
  ident: ppat.1011104.ref013
  article-title: Modelling the risk of adult T-cell leukemia/lymphoma in persons infected with human T-lymphotropic virus type I
  publication-title: Int J Cancer
  doi: 10.1002/ijc.2910430214
– volume: 27
  start-page: 113
  issue: 2
  year: 2011
  ident: ppat.1011104.ref035
  article-title: Short communication: epidemiological evidence that simian T-lymphotropic virus type 1 in Macaca fuscata has an alternative transmission route to maternal infection
  publication-title: AIDS Res Hum Retroviruses
  doi: 10.1089/aid.2010.0082
– volume: 63
  start-page: 103
  issue: 2
  year: 2004
  ident: ppat.1011104.ref033
  article-title: Transmission of STLV in a closed colony of macaques
  publication-title: Am J Primatol
  doi: 10.1002/ajp.20043
– volume: 86
  start-page: 1205
  issue: 5
  year: 2009
  ident: ppat.1011104.ref050
  article-title: Presentation of human T cell leukemia virus type 1 (HTLV-1) Tax protein by dendritic cells: the underlying mechanism of HTLV-1-associated neuroinflammatory disease
  publication-title: J Leukoc Biol
  doi: 10.1189/jlb.0309172
– volume: 77
  start-page: 2956
  issue: 5
  year: 2003
  ident: ppat.1011104.ref022
  article-title: Expansion of human T-cell leukemia virus type 1 (HTLV-1) reservoir in orally infected rats: inverse correlation with HTLV-1-specific cellular immune response
  publication-title: J Virol
  doi: 10.1128/JVI.77.5.2956-2963.2003
– volume: 1
  start-page: 1031
  issue: 8488
  year: 1986
  ident: ppat.1011104.ref003
  article-title: HTLV-I associated myelopathy, a new clinical entity
  publication-title: Lancet
  doi: 10.1016/S0140-6736(86)91298-5
– volume: 362
  start-page: 99
  issue: 1
  year: 2007
  ident: ppat.1011104.ref049
  article-title: Deregulated expression of CD40 ligand in HTLV-I infection: distinct mechanisms of downregulation in HTLV-I-transformed cell lines and ATL patients
  publication-title: Virology
  doi: 10.1016/j.virol.2006.12.020
– volume: 16
  start-page: 41
  issue: 1
  year: 2019
  ident: ppat.1011104.ref031
  article-title: STLV-1 as a model for studying HTLV-1 infection.
  publication-title: Retrovirology
  doi: 10.1186/s12977-019-0503-0
– volume: 117
  start-page: 4855
  issue: 18
  year: 2011
  ident: ppat.1011104.ref025
  article-title: Kinetics and intracellular compartmentalization of HTLV-1 gene expression: nuclear retention of HBZ mRNAs
  publication-title: Blood
  doi: 10.1182/blood-2010-11-316463
– volume: 16
  start-page: 23
  issue: 1
  year: 2019
  ident: ppat.1011104.ref007
  article-title: Impact of host immunity on HTLV-1 pathogenesis: potential of Tax-targeted immunotherapy against ATL
  publication-title: Retrovirology
  doi: 10.1186/s12977-019-0484-z
– volume: 80
  start-page: 7375
  issue: 15
  year: 2006
  ident: ppat.1011104.ref023
  article-title: Reduction of human T-cell leukemia virus type 1 (HTLV-1) proviral loads in rats orally infected with HTLV-1 by reimmunization with HTLV-1-infected cells
  publication-title: J Virol
  doi: 10.1128/JVI.00230-06
– volume: 86
  start-page: 1515
  year: 2005
  ident: ppat.1011104.ref042
  article-title: A functional CD8+ cell assay reveals individual variation in CD8+ cell antiviral efficacy and explains differences in human T-lymphotropic virus type 1 proviral load
  publication-title: J Gen Virol
  doi: 10.1099/vir.0.80766-0
– volume: 50
  start-page: 481
  issue: 3
  year: 1977
  ident: ppat.1011104.ref001
  article-title: Adult T-cell leukemia: clinical and hematologic features of 16 cases
  publication-title: Blood
  doi: 10.1182/blood.V50.3.481.481
– volume: 1
  start-page: 302
  issue: 4
  year: 1998
  ident: ppat.1011104.ref014
  article-title: HTLV-I serostatus of mothers of patients with adult T-cell leukemia and HTLV-I-associated myelopathy/tropical spastic paraparesis
  publication-title: J Hum Virol
– volume: 177
  start-page: 1567
  issue: 6
  year: 1993
  ident: ppat.1011104.ref046
  article-title: High human T cell lymphotropic virus type 1 (HTLV-1)-specific precursor cytotoxic T lymphocyte frequencies in patients with HTLV-1-associated neurological disease
  publication-title: J Exp Med
  doi: 10.1084/jem.177.6.1567
– volume: 109
  start-page: 2383
  issue: 8
  year: 2018
  ident: ppat.1011104.ref019
  article-title: Human T-cell lymphotropic/leukemia virus type 1 (HTLV-1) Tax-specific T-cell exhaustion in HTLV-1-infected individuals
  publication-title: Cancer Sci
  doi: 10.1111/cas.13654
– volume: 313
  start-page: 61
  issue: 1–2
  year: 2006
  ident: ppat.1011104.ref024
  article-title: Human T-cell leukemia virus type-I (HTLV-I)-specific T-cell responses detected using three-divided glutathione-S-transferase (GST)-Tax fusion proteins
  publication-title: J Immunol Methods
  doi: 10.1016/j.jim.2006.03.013
SSID ssj0041316
Score 2.4156566
Snippet A small proportion of human T-cell leukemia virus type-1 (HTLV-1)-infected individuals develop adult T-cell leukemia/lymphoma, a chemotherapy-resistant...
SourceID doaj
pubmedcentral
proquest
gale
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage e1011104
SubjectTerms Animals
Antigens
Asymptomatic
Biology and Life Sciences
Chemotherapy
Cytotoxicity
Dendritic cells
Disease
Epitopes
Flow cytometry
Host-virus relationships
HTLV-I infections
Human T-lymphotropic virus 1
Humans
Immune response
Immunization
Immunoproliferative diseases
In vivo methods and tests
Infections
Leukemia
Leukemia-Lymphoma, Adult T-Cell
Leukocytes, Mononuclear
Lymphocytes
Lymphocytes T
Lymphoma
Macaca fuscata
Medicine and Health Sciences
Mitomycin C
Monkeys
Monkeys & apes
Monoclonal antibodies
Observations
Patients
Peptides
Peripheral blood mononuclear cells
Prevention
Proviruses
Reduction
Research and Analysis Methods
Simian T-lymphotropic virus 1
T-Lymphocytes, Cytotoxic
Testing
Tumor necrosis factor-TNF
Vaccination
Vaccines
Viral envelope proteins
Viruses
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9tAEF5KoNBL6btu07IthZ7UWFppRzompiENSSiNE3IT-xg1BqOYyC7kL_VXdmZXNhal5NKjvbOWdmY8D2nmGyE--UJDhWgSUMomeebHiQVTJeRdoUE7thgahU_P9NFFfnxVXG2N-uKasAgPHBm3p4ylHIS0rsyqPAVrm6aptE8hdYU2OuB8ks9bJ1PRBpNlDkNPeSgO3YXWfdOcgnSvl9GXxcIE-Gjyf_nAKQXs_r8t9JaLGpZPbvmjwyficR9Iyv14gKfiAbbPxMM4WvLuufh9aZybxUd9kh-2yu6aIu2ELXES4TbQS7MK42sp-5ffD04nncSAKEFXnN9Jbnn4RaGol-fTk0tKArkrkyuL5GR60slZKwMqqJkTbU8RS7toxzH5YJ5tKUnLyUx08Ra4JXPG16UfkLexOhe7F-Li8Ot0cpT0cxkSpxUsiaE5psY6531J6ZQHkkmqywKbnAI6T58BU4ACjQI0CCw7B1WWjZGCMVOpl2KnvWnxtZDKobNlWiAFqnlaaptB2aBHT6bG-gJHQq0FU7setJxnZ8zr8CYOKHmJ7K5ZnHUvzpFINrsWEbTjHvoDlvmGliG3wxekiHWviPV9ijgSH1ljagbVaLlq56dZdV397fys3geeP88wP_8k-jEg-twTNTd0WGf6TgliGYN1DSh3B5RkGtxwea2963N3NXGYfIqGMYzEh80y7-RyuxZJ5YgGVEq-jFnzKir7hjm0ld-m65GAwd9gwL3hSju7DsDlVZWVqcre_A92vxWPMoo3QwF9tit2lrcrfEfx4dK-D6bgDxz9ZZY
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3db9MwELfGEBIviG8KAxmExFOm5suXPCC0VUxjWifE2mlvkT8uW6UqLU2L6L_EX8mdk1aLYPDY-pzY5_PdOb77nRDvXaogR9QBxLEJksj1AwM6D8i6Qommb9AnCg_P1PE4OblML3fEpmZry8D6r0c7ric1Xkz3f35ff6IN_9FXbYBw02l_PtceEJosWnJH3CXbBFzTYJhs7xVIY_tiqFwsh0anVJtMd9tTOsbKY_r_qblvmK5uWOUNO3X0UDxoHUx50EjEI7GD1WNxryk5uX4ifl1oayfNJ0DJH2FlfU2TD1hDBw0MBzqpV76s7WxVy6-Hw0Et0SNN0Buna8mpED_IRXXyfHR6QYdDztbkiCM5GJ3WclJJjxaqp0TbUjQhX9TjhGwz17yUJP2kPupmCJyqOeH30gPkoonaxfqpGB99Hg2Og7ZeQ2BVDEtiaIKhNtY6l9Exy4Epy1BlKZYJOXqOfgOGACnqGFAjRGkWWcijqI_kpOk8fiZ2q1mFL4SMLVqThSmSA5uEmTIRZCU6dKSCjEuxJ-LNwhS2BTPnmhrTwt_QAR1qGnYXvJxFu5w9EWx7zRswj__QH_Kab2kZitv_MVtcFe3OLmJt6JAc8WRoqGBo0mWuXAihTZVWcU-8Y4kpGGyj4mieK72q6-LL-VlxAFyXnuF_biX61iH60BKVM5qs1W0GBbGMQbw6lHsdSlIZttu8kd7NvOuCOEy2RkEfeuLttpl7chhehSRyRANxSDaOWfO8EfYtc6gr37KrnoDONuhwr9tSTa49oHmeR1kYRy__PaxX4n5EHqYPmY_2xO5yscLX5BEuzRu_yX8DTeNjiw
  priority: 102
  providerName: Scholars Portal
Title Vaccination with short-term-cultured autologous PBMCs efficiently activated STLV-1-specific CTLs in naturally STLV-1-infected Japanese monkeys with impaired CTL responses
URI https://www.ncbi.nlm.nih.gov/pubmed/36730466
https://www.proquest.com/docview/2787636707
https://www.proquest.com/docview/2773121904
https://pubmed.ncbi.nlm.nih.gov/PMC9928132
https://doaj.org/article/3ab840225829417bbfff96d171c56a63
Volume 19
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3db9MwELdgExIviG8KozIIiaewJk58yRNaq01jWqdpX9pb5K9slaq0NC3S_iX-Su4ctyxCwEul1ufGvrPvzs7d7xj7ZDMJhXMqAiF0lCZ2EGlQRYTWFSqnB9r5ROHxiTy8TI-us-tw4daEsMq1TvSK2s4M3ZHvJkDYaRIG8HX-PaKqUfR2NZTQeMi2CbqMVjVcbw5cqJ996VMqjYNjkTKkzgmId4OkvsznyoNIoxVMO6bJI_j_qafvGapuEOU9q3TwlD0J7iTfa-X_jD1w9XP2qC0wefeC_bxSxkzaCz9OV668uUV_OyJ9HLWgG85ytfJFbGerhp8Ox6OGO48rgU-c3nFKfPiBDqnl5xfHV3gUpNxMii_io4vjhk9q7rFB1RRpA0Ub4IU9jtASU4VLjsxDZdG0Q6DEzAk9F_-AL9oYXde8ZJcH-xejwyhUZ4iMFLBEhqYuVtoYa3M8VFnQVRXLPHNVim6dxe_gYoDMKQFOOUiyPDFQJMnAoUumCvGKbdWz2r1hXBhndB5nDt3VNM6lRmFXzjqLCkfbzPWYWAumNAG6nCpoTEv_Pg7wCNOyuyRxlkGcPRZtes1b6I7_0A9J5htaAt72P8wWN2XYx6VQGo_ECU0GhwoaJ10V0sYQm0wqKXrsI62YkqA1aorduVGrpim_nZ-Ue0BV6Ans569EZx2iz4GomuFkjQr5EsgyguzqUO50KFFBmG7zevWu592Uv7dTj33YNFNPCrqrHS45pAERo0Uj1rxuF_uGOdiV3qnLHoPONuhwr9tST249fHlRJHkskrf_HtY79jhBf9IHyCc7bGu5WLn36P8tdd9v8j7bHu6fnJ71_S0Kfo7T_BcRZWE9
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF5VRQguiDeBAgsCcTKN14-NDwi1gSptkwjRtMrN7GPcRoqcECeg_CUO_EZm1naohYBTj7Fn492d8TzWM98w9spGsUwAlCeDQHuhsG1PS5V4aF1lBrqtwRUKD4Zx7zQ8GkfjLfazroWhtMpaJzpFbWeGzsh3hSTstFi25fv5V4-6RtHX1bqFRikWx7D-jiFb8e7wA_L3tRAHH0fdnld1FfBMHMglTioEX2ljrO1gMGClzjI_7kSQheiOWPwtwZcyAhVIUCBF1BFGJkK0AV0JReBLqPKvoeFtU7Anx5sAD-2Ba7VKrXjwMXFcleoF0t-tJOPtfK4caDVa3bBhCl3HgD_twiXD2EzavGQFD26zW5X7yvdKebvDtiC_y66XDS3X99iPM2XMpDxg5HTEy4sL9O890v9eCfIBlquVa5o7WxX80_6gW3BwOBb4xOmaU6HFN3SALT8Z9c8w9KRaUMpn4t1Rv-CTnDssUjVF2oqiTCjDEUdo-amjJkdmoXIqyilQIeiEnot_wBdlTjAU99nplfDtAdvOZzk8YjwwYHTHjwDd49DvxBqFKwMLFhWcthG0WFAzJjUVVDp17Jim7vufxJCp3O6U2JlW7GwxbzNqXkKF_Id-n3i-oSWgb3dhtjhPK72RBkpjCC5oMThVqXHRWRJbX_omilUctNhLkpiUoDxyyhU6V6uiSA9PhumepK73BC70V6LPDaI3FVE2w8UaVdVn4JYRRFiDcqdBiQrJNG_X0luvu0h_v74t9mJzm0ZSkl8OKHJIIwMfLShtzcNS2Debg0PpG37cYrLxGjR2r3knn1w4uPQkER0_EI__Pa3n7EZvNOin_cPh8RN2U6Av65LzxQ7bXi5W8BR9z6V-5l54zr5ctYb5BdgkmwE
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELemTiBeEN8UBhgE4im0sRM7eUBo7VatW1dVWzftLXNsZ6tUpaVpQf2X-BP467jLR1mEgKc9Nj7XH3e-Oyd3vyPkvfGFDK1VjuQ8djxm2k4sVeiAdZWJjduxzROFj4fi4Mw7vPAvtsjPKhcGwyornZgrajPT-I68xSRipwnZlq2kDIsY7fW-zL86WEEKv7RW5TQKETmy6-9wfcs-9_eA1x8Y6-2PuwdOWWHA0YLLJUzQs66KtTYmgIuBkXGSuCLwbeKBa2Lgt7SulL5VXFplJfMDpmXIWNuCW6EQiAnU_7bEW1GDbHf2h6OTyg6AdcgLr2JhHhhIiDJxj0u3VcrJp_lc5RDWYIO9mmHM6wf8aSVumMl6COcNm9h7QO6XzizdLaTvIdmy6SNypyhvuX5MfpwrrSfF60aKL3xpdg3evoPWwCkgP6yhapWX0J2tMjrqHHczanNUCxhxuqaYdvEN3GFDT8eDc7iIYmYoRjfR7niQ0UlKc2RSNQXakqIIL4Meh-AHYH1NCuwCVZUVU8C00AmOC39AF0WEsM2ekLNb4dxT0khnqX1OKNdWx4HrW3CWPTcQMYhaYo01oO5i49sm4RVjIl0Cp2P9jmmUfw2UcIEqtjtCdkYlO5vE2fSaF8Ah_6HvIM83tAj7nT-YLa6iUotEXMVwIWe4GJiqjGHRSSiMK13tCyV4k7xDiYkQ2CPFI3KlVlkW9U-H0a7koddGqKG_Ep3UiD6WRMkMFqtVma0BW4aAYTXKnRolqCddb66kt1p3Fv0-zE3ydtOMPTHkL7UgckAjuQv2FLfmWSHsm82BrvhFXzSJrB2D2u7VW9LJdQ6eHoYscDl78e9pvSF3QbtEg_7w6CW5x8CxzSP12Q5pLBcr-woc0WX8ujzxlFzetpL5BeMpoJw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Vaccination+with+short-term-cultured+autologous+PBMCs+efficiently+activated+STLV-1-specific+CTLs+in+naturally+STLV-1-infected+Japanese+monkeys+with+impaired+CTL+responses&rft.jtitle=PLoS+pathogens&rft.au=Hasegawa%2C+Atsuhiko&rft.au=Murata%2C+Megumi&rft.au=Fujikawa%2C+Tomoka&rft.au=Katagiri%2C+Kuniko&rft.date=2023-02-02&rft.pub=Public+Library+of+Science&rft.issn=1553-7366&rft.eissn=1553-7374&rft.volume=19&rft.issue=2&rft.spage=e1011104&rft_id=info:doi/10.1371%2Fjournal.ppat.1011104&rft.externalDBID=HAS_PDF_LINK
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1553-7374&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1553-7374&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1553-7374&client=summon