Epigenetic repression of antiviral genes by SARS-CoV-2 NSP1

• Published in: PloS one Vol. 19; no. 1; p. e0297262
• Main Authors: Anastasakis, Dimitrios G, Benhalevy, Daniel, Çuburu, Nicolas, Altan-Bonnet, Nihal, Hafner, Markus
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.01.2024; Public Library of Science (PLoS)
• Subjects: Analysis; Antiviral Agents - pharmacology; Antiviral drugs; Cell culture; Coronaviruses; COVID-19; COVID-19 - genetics; Cytomegalovirus; Epigenetic inheritance; Epigenetic Repression; Epigenetics; Ethanol; Footprinting; Gene expression; Gene silencing; Genes; Genetic aspects; Genetic transcription; Histones; Humans; Immune evasion; Immunomodulation; Infections; Kinases; Lysine; Messenger RNA; Methylation; Methyltransferase; Molecular dynamics; Plasmids; Proteins; Ribonucleic acid; RNA; SARS-CoV-2 - genetics; SARS-CoV-2 - metabolism; Scientific equipment and supplies industry; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Shutdowns; Transferases; Viral diseases; Viral Nonstructural Proteins - metabolism; Viral proteins; Virus diseases; Viruses; United States

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades the innate immune machinery through multiple viral proteins, including nonstructural protein 1 (NSP1). While NSP1 is known to suppress translation of host mRNAs, the mechanisms underlying its immune evasion properties remain elu...