Durability of humoral immune responses to rubella following MMR vaccination
While administration of the measles-mumps-rubella (MMR-II®) vaccine has been effective at preventing rubella infection in the United States, the durability of humoral immunity to the rubella component of MMR vaccine has not been widely studied among older adolescents and adults. In this longitudinal...
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| Published in | Vaccine Vol. 38; no. 51; pp. 8185 - 8193 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier Ltd
03.12.2020
Elsevier Limited |
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| Abstract | While administration of the measles-mumps-rubella (MMR-II®) vaccine has been effective at preventing rubella infection in the United States, the durability of humoral immunity to the rubella component of MMR vaccine has not been widely studied among older adolescents and adults.
In this longitudinal study, we sought to assess the durability of rubella virus (RV)-specific humoral immunity in a healthy population (n = 98) of adolescents and young adults at two timepoints: ~7 and ~17 years after two doses of MMR-II® vaccination. Levels of circulating antibodies specific to RV were measured by ELISA and an immune-colorimetric neutralization assay. RV-specific memory B cell responses were also measured by ELISpot.
Rubella-specific IgG antibody titers, neutralizing antibody titers, and memory B cell responses declined with increasing time since vaccination; however, these decreases were relatively moderate. Memory B cell responses exhibited a greater decline in men compared to women.
Collectively, rubella-specific humoral immunity declines following vaccination, although subjects’ antibody titers remain well above the currently recognized threshold for protective immunity. Clinical correlates of protection based on neutralizing antibody titer and memory B cell ELISpot response should be defined. |
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| AbstractList | While administration of the measles-mumps-rubella (MMR-II®) vaccine has been effective at preventing rubella infection in the United States, the durability of humoral immunity to the rubella component of MMR vaccine has not been widely studied among older adolescents and adults.
In this longitudinal study, we sought to assess the durability of rubella virus (RV)-specific humoral immunity in a healthy population (n = 98) of adolescents and young adults at two timepoints: ~7 and ~17 years after two doses of MMR-II® vaccination. Levels of circulating antibodies specific to RV were measured by ELISA and an immune-colorimetric neutralization assay. RV-specific memory B cell responses were also measured by ELISpot.
Rubella-specific IgG antibody titers, neutralizing antibody titers, and memory B cell responses declined with increasing time since vaccination; however, these decreases were relatively moderate. Memory B cell responses exhibited a greater decline in men compared to women.
Collectively, rubella-specific humoral immunity declines following vaccination, although subjects' antibody titers remain well above the currently recognized threshold for protective immunity. Clinical correlates of protection based on neutralizing antibody titer and memory B cell ELISpot response should be defined. AbstractBackgroundWhile administration of the measles-mumps-rubella (MMR-II®) vaccine has been effective at preventing rubella infection in the United States, the durability of humoral immunity to the rubella component of MMR vaccine has not been widely studied among older adolescents and adults. MethodsIn this longitudinal study, we sought to assess the durability of rubella virus (RV)-specific humoral immunity in a healthy population (n = 98) of adolescents and young adults at two timepoints: ~7 and ~17 years after two doses of MMR-II® vaccination. Levels of circulating antibodies specific to RV were measured by ELISA and an immune-colorimetric neutralization assay. RV-specific memory B cell responses were also measured by ELISpot. ResultsRubella-specific IgG antibody titers, neutralizing antibody titers, and memory B cell responses declined with increasing time since vaccination; however, these decreases were relatively moderate. Memory B cell responses exhibited a greater decline in men compared to women. ConclusionsCollectively, rubella-specific humoral immunity declines following vaccination, although subjects’ antibody titers remain well above the currently recognized threshold for protective immunity. Clinical correlates of protection based on neutralizing antibody titer and memory B cell ELISpot response should be defined. BackgroundWhile administration of the measles-mumps-rubella (MMR-II®) vaccine has been effective at preventing rubella infection in the United States, the durability of humoral immunity to the rubella component of MMR vaccine has not been widely studied among older adolescents and adults.MethodsIn this longitudinal study, we sought to assess the durability of rubella virus (RV)-specific humoral immunity in a healthy population (n = 98) of adolescents and young adults at two timepoints: ~7 and ~17 years after two doses of MMR-II® vaccination. Levels of circulating antibodies specific to RV were measured by ELISA and an immune-colorimetric neutralization assay. RV-specific memory B cell responses were also measured by ELISpot.ResultsRubella-specific IgG antibody titers, neutralizing antibody titers, and memory B cell responses declined with increasing time since vaccination; however, these decreases were relatively moderate. Memory B cell responses exhibited a greater decline in men compared to women.ConclusionsCollectively, rubella-specific humoral immunity declines following vaccination, although subjects’ antibody titers remain well above the currently recognized threshold for protective immunity. Clinical correlates of protection based on neutralizing antibody titer and memory B cell ELISpot response should be defined. While administration of the measles-mumps-rubella (MMR-II®) vaccine has been effective at preventing rubella infection in the United States, the durability of humoral immunity to the rubella component of MMR vaccine has not been widely studied among older adolescents and adults.BACKGROUNDWhile administration of the measles-mumps-rubella (MMR-II®) vaccine has been effective at preventing rubella infection in the United States, the durability of humoral immunity to the rubella component of MMR vaccine has not been widely studied among older adolescents and adults.In this longitudinal study, we sought to assess the durability of rubella virus (RV)-specific humoral immunity in a healthy population (n = 98) of adolescents and young adults at two timepoints: ~7 and ~17 years after two doses of MMR-II® vaccination. Levels of circulating antibodies specific to RV were measured by ELISA and an immune-colorimetric neutralization assay. RV-specific memory B cell responses were also measured by ELISpot.METHODSIn this longitudinal study, we sought to assess the durability of rubella virus (RV)-specific humoral immunity in a healthy population (n = 98) of adolescents and young adults at two timepoints: ~7 and ~17 years after two doses of MMR-II® vaccination. Levels of circulating antibodies specific to RV were measured by ELISA and an immune-colorimetric neutralization assay. RV-specific memory B cell responses were also measured by ELISpot.Rubella-specific IgG antibody titers, neutralizing antibody titers, and memory B cell responses declined with increasing time since vaccination; however, these decreases were relatively moderate. Memory B cell responses exhibited a greater decline in men compared to women.RESULTSRubella-specific IgG antibody titers, neutralizing antibody titers, and memory B cell responses declined with increasing time since vaccination; however, these decreases were relatively moderate. Memory B cell responses exhibited a greater decline in men compared to women.Collectively, rubella-specific humoral immunity declines following vaccination, although subjects' antibody titers remain well above the currently recognized threshold for protective immunity. Clinical correlates of protection based on neutralizing antibody titer and memory B cell ELISpot response should be defined.CONCLUSIONSCollectively, rubella-specific humoral immunity declines following vaccination, although subjects' antibody titers remain well above the currently recognized threshold for protective immunity. Clinical correlates of protection based on neutralizing antibody titer and memory B cell ELISpot response should be defined. While administration of the measles-mumps-rubella (MMR-II®) vaccine has been effective at preventing rubella infection in the United States, the durability of humoral immunity to the rubella component of MMR vaccine has not been widely studied among older adolescents and adults.In this longitudinal study, we sought to assess the durability of rubella virus (RV)-specific humoral immunity in a healthy population (n = 98) of adolescents and young adults at two timepoints: ~7 and ~17 years after two doses of MMR-II® vaccination. Levels of circulating antibodies specific to RV were measured by ELISA and an immune-colorimetric neutralization assay. RV-specific memory B cell responses were also measured by ELISpot.Rubella-specific IgG antibody titers, neutralizing antibody titers, and memory B cell responses declined with increasing time since vaccination; however, these decreases were relatively moderate. Memory B cell responses exhibited a greater decline in men compared to women.Collectively, rubella-specific humoral immunity declines following vaccination, although subjects’ antibody titers remain well above the currently recognized threshold for protective immunity. Clinical correlates of protection based on neutralizing antibody titer and memory B cell ELISpot response should be defined. |
| Author | Icenogle, Joseph P. Chen, Min-Hsin Warner, Nathaniel D. Hao, Lijuan Riggenbach, Marguerite M. Ovsyannikova, Inna G. Kennedy, Richard B. Crooke, Stephen N. Poland, Gregory A. |
| AuthorAffiliation | 2 Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN USA 3 Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA USA 1 Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN USA |
| AuthorAffiliation_xml | – name: 2 Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN USA – name: 1 Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN USA – name: 3 Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA USA |
| Author_xml | – sequence: 1 givenname: Stephen N. orcidid: 0000-0002-4711-5767 surname: Crooke fullname: Crooke, Stephen N. organization: Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, USA – sequence: 2 givenname: Marguerite M. surname: Riggenbach fullname: Riggenbach, Marguerite M. organization: Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, USA – sequence: 3 givenname: Inna G. surname: Ovsyannikova fullname: Ovsyannikova, Inna G. organization: Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, USA – sequence: 4 givenname: Nathaniel D. surname: Warner fullname: Warner, Nathaniel D. organization: Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA – sequence: 5 givenname: Min-Hsin surname: Chen fullname: Chen, Min-Hsin organization: Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA – sequence: 6 givenname: Lijuan surname: Hao fullname: Hao, Lijuan organization: Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA – sequence: 7 givenname: Joseph P. surname: Icenogle fullname: Icenogle, Joseph P. organization: Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA – sequence: 8 givenname: Gregory A. orcidid: 0000-0001-5057-4457 surname: Poland fullname: Poland, Gregory A. organization: Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, USA – sequence: 9 givenname: Richard B. surname: Kennedy fullname: Kennedy, Richard B. email: kennedy.rick@mayo.edu organization: Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33190948$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1038_s41541_021_00412_6 crossref_primary_10_1186_s12889_024_20081_z crossref_primary_10_1016_j_clim_2021_108912 crossref_primary_10_1080_14760584_2024_2331065 crossref_primary_10_1126_scitranslmed_abi5735 crossref_primary_10_1093_ofid_ofad700 |
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| Snippet | While administration of the measles-mumps-rubella (MMR-II®) vaccine has been effective at preventing rubella infection in the United States, the durability of... AbstractBackgroundWhile administration of the measles-mumps-rubella (MMR-II®) vaccine has been effective at preventing rubella infection in the United States,... BackgroundWhile administration of the measles-mumps-rubella (MMR-II®) vaccine has been effective at preventing rubella infection in the United States, the... |
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| SubjectTerms | Adolescent Adolescents Adult Adults Age Allergy and Immunology Antibodies Antibodies, Neutralizing - immunology Antigens B-lymphocytes B-Lymphocytes - immunology Colorimetry Congenital diseases Correlation analysis Durability Enzyme-linked immunosorbent assay Female Fetuses Humans Humoral immunity IgG antibody Immune response Immune response (humoral) Immunity Immunity, Humoral Immunoglobulin G Immunoglobulin G - blood Immunological memory Infections Longitudinal studies Male Measles Measles-Mumps-Rubella Vaccine - immunology Measles-Mumps-Rubella Vaccine - pharmacology Men MMR-II vaccine Mumps Neutralization neutralization tests Neutralizing Rubella Rubella - immunology Rubella - prevention & control Rubella vaccine Rubella virus Time Factors Vaccination Vaccines Viruses Waning immunity Young Adult Young adults |
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| Title | Durability of humoral immune responses to rubella following MMR vaccination |
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