KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes

• Published in: Nature cell biology Vol. 22; no. 4; pp. 380 - 388
• Main Authors: Sankar, Aditya, Lerdrup, Mads, Manaf, Adeel, Johansen, Jens Vilstrup, Gonzalez, Javier Martin, Borup, Rehannah, Blanshard, Robert, Klungland, Arne, Hansen, Klaus, Andersen, Claus Yding, Dahl, John Arne, Helin, Kristian, Hoffmann, Eva R.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2020; Nature Publishing Group
• Subjects: 14/1; 14/19; 14/34; 38/1; 38/91; 45/15; 45/91; 631/136/2086; 631/337/176; 64/110; Animals; Biomedical and Life Sciences; Cancer Research; Catalytic activity; Cell Biology; Demethylation; Developmental Biology; Domains; Embryo Implantation; Embryo, Mammalian; Embryonic development; Embryos; Enzymes; Epigenetic inheritance; Epigenetics; Female; Fertilization; Fertilization - genetics; Gametocytes; Genetic aspects; Genetic research; Genomes; Heterochromatin; Heterochromatin - chemistry; Heterochromatin - metabolism; Histone Demethylases - genetics; Histone Demethylases - metabolism; Histone H3; Histones; Histones - genetics; Histones - metabolism; Hydrolases; Implantation; Letter; Life Sciences; Lysine; Male; Mammals; Metaphase; Methylation; Mice; Mice, Knockout; Oocytes; Oocytes - cytology; Oocytes - growth & development; Oocytes - metabolism; Post-translation; Post-translational modification; Priming; Promoter Regions, Genetic; Protein Processing, Post-Translational; Stem Cells; Transcription activation; Transcription, Genetic; Zygote - cytology; Zygote - growth & development; Zygote - metabolism; Zygotes; Denmark

The importance of germline-inherited post-translational histone modifications on priming early mammalian development is just emerging 1 – 4 . Histone H3 lysine 9 (H3K9) trimethylation is associated with heterochromatin and gene repression during cell-fate change 5 , whereas histone H3 lysine 4 (H3K4...